The whey fermentation product malleable protein matrix decreases TAG concentrations in patients with the metabolic syndrome: a randomised placebo-controlled trial

Abstract

Animal and human studies suggest that a malleable protein matrix (MPM) from whey decreases plasma lipid concentrations and may positively influence other components of the metabolic syndrome such as glucose metabolism and blood pressure (BP). The primary objective of this double-blind, multi-centre trial was to investigate the effects of a low-fat yoghurt supplemented with whey MPM on fasting TAG concentrations in patients with the metabolic syndrome. A total of 197 patients were randomised to receive MPM or a matching placebo yoghurt identical in protein content (15 g/d). Patients were treated during 3 months with two daily servings of 150 g yoghurt each to compare changes from baseline in efficacy variables. MPM treatment resulted in a significantly larger reduction of TAG concentrations in comparison to placebo (relative change 216 %, P¼ 0·004). The difference was even more pronounced in subjects with elevated fasting TAG ($ 200 mg/dl) at baseline (218 %, P¼0·005). The relative treatment difference in fasting plasma glucose was 2 7·1 mg/dl (P¼ 0·089). This effect was also more pronounced in subjects with impaired fasting glucose at baseline (211 mg/dl, P¼ 0·03). In patients with hypertension, the relative treatment difference in systolic BP reached 25·9 mmHg (P¼ 0·054). The relative treatment difference in body weight was 21·7 kg (P¼0·015). The most common adverse events were gastrointestinal in nature. Conclusions from the present study are that consumption of a low-fat yoghurt supplemented with whey MPM twice a day over 3 months significantly reduces fasting TAG concentrations in patients with the metabolic syndrome and improves multiple other cardiovascular risk factors.

Whey protein lowers blood pressure and improves endothelial function and lipid biomarkers in adults with prehypertension and mild hypertension: results from the chronic Whey2Go randomized controlled trial

“…In our recent review, we identified 4 RCTs and a pilot study that evaluated the long-term effects of dairy proteins on lipid metabolism (50). Our results are in agreement with the majority of these studies (51–53); however, we failed to detect a decrease in LDL cholesterol or an increase in HDL cholesterol. Longer supplementation periods with milk proteins may have been more informative on the relative effects of dairy proteins on other lipid profiles or on the strength of significance.…”

Milk protein for improved metabolic health: a review of the evidence

“…Dairy proteins have potential to suppress postprandial lipaemia due to their insulinotropic effects, as insulin is known to inhibit hormone-sensitive lipase and release of FFA [62]. However, studies on the effects of milk protein ingestion on postprandial lipaemia and chronic dyslipidaemia have produced mixed findings [63-70]. Two studies in healthy normolipaemic young men and women reported that 50 g sodium caseinate suppressed the postprandial response following a 70 g fat bolus, decreasing diet-derived chylomicrons and FFAs independent of gastric emptying, compared to an oligosaccharide bolus [64,65].…”

“…In a study of metabolic syndrome, a significant decrease in fasting TG was demonstrated following a 3 month period of supplementation of 15 g/day of a fermented whey product, whey malleable protein matrix (MPM, comprising whey proteins, peptides, a probiotic, polysaccharides and calcium) [70], as were other risk factors but only in individuals with high pre-existing metabolic risk. Metabolic outcomes in this study may have been driven by weight loss since body weight also decreased following MPM supplementation.…”

Effect of Whey Supplementation on Circulating C-Reactive Protein: A Meta-Analysis of Randomized Controlled Trials

“…After a full-text review of the remaining 21 potentially relevant articles, 12 articles were further excluded because they used milk other than whey and its derivates as the intervention products (three articles), measured an acute effect (two articles), did not report the CRP data (five articles) or had no control group (two articles). Finally, nine RCTs were selected for our meta-analysis [ 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ] ( Figure 1 ).…”