The wide spectrum of cryptococcal infections

Lewis, Jerry L.; Rabinovich, S. A.

doi:10.1016/0002-9343(72)90174-x

Cited by 240 publications

(84 citation statements)

References 12 publications

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“…Até o advento da anfotericina B, em 1956, a doença tinha curso invariavelmente fatal [2][3][4] e, mesmo com o surgimento de novas abordagens terapêuticas, as taxas de letalidade e recidiva ainda permanecem elevadas 5 .…”

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Fatores prognósticos da meningoencefalite criptocócica

Darzé¹,

Lucena²,

Gomes³

et al. 1999

Arq. Neuro-Psiquiatr.

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RESUMO - Prognostic factors in cryptococcal meningoencephalitisABSTRACT -Objective: To identify demographic, clinical and cerebrospinal fluid (CSF) variables associated to intrahospitalar lethality of patients with cryptococcal meningoencephalitis. Study design: Retrospective cohort to study prognosis. Setting: Hospital Couto Maia (HCMaia) reference for patients with infectious diseases in the State of Bahia Northeastern Brazil. Population: Patients admitted at HCMaia, from 1972 to 1996, with the diagnosis of cryptococcal meningoencephalitis. Results: Lethality rate was 42.7%. The most important neurological abnormalities were neck stiffness, decreased consciousness level, behavior changes, cranial nerve palsy and visual alterations. Disease time over 30 days, involvement of consciousness level and cerebrospinal fluid cells under 40/mm³ were associated to a higher lethality rate. Conclusion: Disease time over 30 days, involvement of consciousness level, and CSF decreased cellularity were the only predictors of lethality in the studied population.

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Fatores prognósticos da meningoencefalite criptocócica

Darzé¹,

Lucena²,

Gomes³

et al. 1999

Arq. Neuro-Psiquiatr.

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“…It was 3 times commoner in men than in women and was rarely seen in children . Reports exist that Cryptococcus Neoformans Var Gatti causes 70-80% of cryptococcal infections occuring in hosts who are immunocompetent [4]. However, to the best of our knowledge, none of the reports pertains to the strain Cryptococcus Neoformans Var Humicolus.Our patient who had disseminated cryptococcosis was immunocompetent.…”

Section: Discussionmentioning

confidence: 95%

Disseminated cryptococcosis in an immunocompetent child

Godbole

Nayar

Pradhan

et al. 2007

Indian J Hematol Blood Transfus

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“…They usually settle in brain to cause meningoencephalitis [7] which maybe fatal if left untreated [8]. Till early 1980s, cryptococcosis was a rare infection and as many as a third of all patients gave history of steroid use [9]. The numbers steadily increased with the advent of HIV pandemic, it is the third most common cause of central nervous system infection [10].…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of Cryptococcal Meningitis Associated with HIV in an Indian Hospital

Duggal¹,

Duggal²,

Hans³

et al. 2014

Epidemiol

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Cryptococcus neoformans is an emerging pathogen especially in the setting of HIV infected patients with meningitis. The infection usually manifests in patients with impaired cell mediated immunity. Forty six culture positive cases of cryptococcal meningitis were identified over a period of three years from a tertiary care institute in Delhi. The patients were predominantly males (91%) of reproductive age group, mostly residing in and around Delhi. Most significant co-infections were HIV infection in 93% and tuberculosis in 43.5% cases. All forty six strains belonged to Cryptococcus neoformans var grubii, molecular type VN I, mating type α (MAT α). There was 100% susceptibility to amphotericin B and azoles, one isolate was resistant to 5-fluorocytosine (MIC 64 µg/ml). Cerebrospinal fluid in symptomatic HIV patients should be carefully screened for Cryptococcus spp. which should be identified and also typed for epidemiological purposes.

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The wide spectrum of cryptococcal infections

Cited by 240 publications

References 12 publications

Fatores prognósticos da meningoencefalite criptocócica

Fatores prognósticos da meningoencefalite criptocócica

Disseminated cryptococcosis in an immunocompetent child

Epidemiology of Cryptococcal Meningitis Associated with HIV in an Indian Hospital

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