Let
S
=
ℤ
ℊ
3
×
ℤ
I
1
I
2
be a commutative ring where
ℊ
,
I
1
and
I
2
are positive prime integers with
I
1
≠
I
2
. The zero-divisor graph assigned to S is an undirected graph, denoted as
Y
S
with vertex set V(
Y
(S)) consisting of all Zero-divisor of the ring S and for any c, d
∈
V(
Y
(S)),
c
d
∈
E
Y
S
if and only if cd =0. A topological index/descriptor is described as a topological-invariant quantity that transforms a molecular graph into a mathematical real number. In this paper, we have computed distance-based polynomials of
Y
R
i-e Hosoya polynomial, Harary polynomial, and the topological indices related to these polynomials namely Wiener index, and Hyper-Wiener index.