An increasing number of results in sentence and discourse processing demonstrate that comprehension relies on rich pragmatic knowledge about real-world events, and that incoming words incrementally activate such knowledge. If so, then even outside of any larger context, nouns should activate knowledge of the generalized events that they denote or typically play a role in. We used short stimulus onset asynchrony priming to demonstrate that (1) event nouns prime people (saleshopper) and objects (trip-luggage) commonly found at those events; (2) location nouns prime people/animals (hospital-doctor) and objects (barn-hay) commonly found at those locations; and (3) instrument nouns prime things on which those instruments are commonly used (key-door), but not the types of people who tend to use them (hose-gardener). The priming effects are not due to normative word association. On our account, facilitation results from event knowledge relating primes and targets. This has much in common with computational models like LSA or BEAGLE in which one word primes another if they frequently occur in similar contexts. LSA predicts priming for all six experiments, whereas BEAGLE correctly predicted that priming should not occur for the instrument-people relation but should occur for the other five. We conclude that event-based relations are encoded in semantic memory and computed as part of word meaning, and have a strong influence on language comprehension.What information do comprehenders use as they read and understand words and sentences? As a variety of results in sentence and discourse processing demonstrate, a crucial part of this information is knowledge of common events or situations in the world (Altmann, 1999;Altmann & Kamide, 1999;Camblin, Gordon, & Swaab, 2007;Hess, Foss, & Carroll, 1995;MacDonald, 1994;McKoon & Ratcliff, 2005;Vu, Kellas, Petersen, & Metcalf, 2003). But although such information is known to be important at the sentence level, it is rarely addressed at the level of individual words. Priming studies investigating word meaning tend to focus instead on semantic relatedness, often narrowly defined as the relationship between members of the same category, such as horse and cow (Fischler, 1977;Lupker, 1984;Shelton & Martin, 1992), or on a broader set of associative relations, generally determined through a normative word association task. With the notable exception of Moss, Ostrin, Tyler, and Marslen-Wilson (1995), very few investigations into the organization of semantic memory have addressed the role of event-or situation-based relations.This appears to be a crucial gap in the literature, because in order to understand the influence of event knowledge on comprehension, we must also understand what information is made available when specific words (or classes of words) are encountered. One fruitful method for investigating this issue is semantic priming. In this article, we present a set of priming studies Address correspondence concerning this article to: Mary Hare, Department of Psychology, Bowl...