The Winding Road towards an Atropo‐enantioselective ‘ARYNE Coupling’

Abstract

For the first time, the challenging atropo-enantioselective coupling of in-situ generated arynes and aryllithiums in the presence of a chiral ligand of lithium was investigated. This preliminary study demonstrates the feasibility of this concept, by affording enantioenriched axially chiral biaryls even in the case of products showing a high degree of steric congestion around the newly created arylÀ aryl bond.