The woodchuck model of hepadnavirus infection

Tennant, Bud C.; Hornbuckle, William E.; Gerin, John L.

doi:10.1007/978-3-7643-8558-3_13

Comparative Hepatitis

DOI: 10.1007/978-3-7643-8558-3_13

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The woodchuck model of hepadnavirus infection

Bud C. Tennant

William E. Hornbuckle

John L. Gerin

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“…Possible etiologies for hepatocellular neoplasia in domestic or laboratory animal species include infectious etiology and toxin or chemical exposure. Infectious agents associated with hepatocellular tumors include Helicobacter infection in mice, hepadnavirus infection in woodchucks, squirrels, certain avian species, and human beings, 13 and Hepatitis B virus and Hepatitis C virus in human beings. 2 There was no evidence of infectious etiology in the histologic sections in the group of pigs described herein; however, additional testing for viral etiology was not performed.…”

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Hepatocellular carcinomas in Vietnamese pot-bellied pigs (Sus scrofa)

Haddad

Habecker

2012

J VET Diagn Invest

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Various neoplasms have been reported in Vietnamese pot-bellied pigs ( Sus scrofa) with few reports of hepatocellular tumors. Twenty-two pot-bellied pigs diagnosed with hepatocellular carcinoma at necropsy over a 3-year period at one institution are described, representing 29% of the total pot-bellied pigs necropsied. The average age of affected pigs was 16.6 years with 15 males and 7 females. The most common clinical signs were decreased appetite (16/22) and weight loss (7/22). Grossly, the majority were massive tumors (13/22) with fewer nodular tumors (8/22) and 1 diffuse tumor. Massive tumors were typically multilobulated, very large, and encompassing 1 or more adjacent liver lobes, and were soft to firm and tan-yellow to orange-brown. Nodular tumors had multiple, 1–15 cm in diameter, discrete nodules in multiple liver lobes. Gross evidence of abscesses, necrosis, hemorrhage, or cysts associated with the tumor was occasionally described. Half of the cases had possible intrahepatic metastasis, and extrahepatic metastasis was identified in 3 cases, including to the hepatic lymph node (1/3), lung (2/3), spleen (1/3), and kidney (1/3). Histologically, all tumors had a trabecular or solid pattern, or a combination. An adenoid pattern was only identified in small regions of a few tumors. The neoplastic cells were relatively well-differentiated with moderate pleomorphism and a low mitotic index. Other histologic features within the tumors included intracellular glycogen or lipid accumulation, extramedullary hematopoiesis, foci of coagulative necrosis, and bile stasis. Aged pot-bellied pigs can be predisposed to hepatocellular carcinomas, which are locally aggressive and can metastasize within the liver and to other organs.

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confidence: 99%

Hepatocellular carcinomas in Vietnamese pot-bellied pigs (Sus scrofa)

Haddad

Habecker

2012

J VET Diagn Invest

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The woodchuck model of hepadnavirus infection

Cited by 1 publication

References 150 publications

Hepatocellular carcinomas in Vietnamese pot-bellied pigs (Sus scrofa)

Hepatocellular carcinomas in Vietnamese pot-bellied pigs (Sus scrofa)

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