The World of 5G

Xue, Quan; Che, Wenquan; Guo, Jishun; Wu, Wei; Xu, Zhiqiang; Huang, Wenhua; Lin, Haibin

doi:10.1142/12479

Cited by 5 publications

(7 citation statements)

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“…A previous study has shown that hernandezine extracted from Thalictrum glandulosissimum can significantly inhibit the growth of mouse leukemia L1210 cells and block the cell cycle at the G1 to S stage . To explore the way by which hernandezine inhibits melanoma cell proliferation, the cycle distribution of hernandezine-treated cells was analyzed.…”

Section: Resultsmentioning

confidence: 99%

Hernandezine Regulates Proliferation and Autophagy-Induced Apoptosis in Melanoma Cells

Wang

Yuan

et al. 2022

J. Nat. Prod.

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Hernandezine is isolated from an herbal medicine that selectively inhibits multidrug resistance and improves the efficacy of drugs for cancer treatment. To date, no studies on hernandezine in melanoma have been conducted. In this study, hernandezine was found to inhibit proliferation and induce apoptosis in melanoma A375 cells and B16 cells. In hernandezine-treated melanoma cells, G0/G1 cycle arrest occurred accompanied by significantly downregulated levels of phosphorylated JAK2 and STAT3. In addition, the cycle arrest could be enhanced by AG490 (JAK2 inhibitor), suggesting that the JAK2/STAT3 pathway is involved in cell cycle regulation in hernandezine-treated melanoma cells. Hernandezine-treated melanoma cells exhibited autophagy-specific structures, autophagy markers (LC3II/LC3-I), and autophagic flow over time. Moreover, 3-MA (autophagy inhibitor) significantly inhibited apoptosis, indicating that hernandezine promotes apoptosis by inducing autophagy. Combined with differential expression of P-AMPK, P-ACC (downstream targets of adenine monophosphate activated protein kinase, AMPK), and P-p70S6K (downstream targets of mammalian target of rapamycin, mTOR) and significant inhibition of apoptosis by AMPK inhibitor complex C (CC) in hernandezine-treated melanoma cells suggested that hernandezine could induce autophagy via the AMPK–mTOR pathway, thereby inducing apoptosis. This study first analyzed the effect of melanoma cells by hernandezine and provided a theory for hernandezine in the treatment of melanoma.

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Section: Resultsmentioning

confidence: 99%

Hernandezine Regulates Proliferation and Autophagy-Induced Apoptosis in Melanoma Cells

Wang

Yuan

et al. 2022

J. Nat. Prod.

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“…Thioflavin T or S has high sensitivity in detection of amyloid in tissue. Thioflavin T is popular, in view of its higher sensitivity and the ability to quantify the amyloid protein detected by this stain [10].…”

Section: Stains Used In Demonstration Of Amyloid In Tissue Sectionsmentioning

confidence: 99%

“…Thioflavin T is a fluorescent dye, thus requiring IF examination for amyloid detection [10]. Examination of Congo-red stain using Texas Red filter, increases the diagnostic sensitivity and specificity of this stain.…”

Section: Role Of Immunofluorescence In Diagnostic Work-up Of Amyloidosismentioning

confidence: 99%

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Diagnosis of Amyloidosis: Clinicopathological Advances and Challenges

Ganesh¹,

Truong²

2024

Physiology

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Amyloidosis is a systemic disease with different subtypes of misfolded, insoluble proteins, which are deposited in viscera and thereby cause damage to the affected organs. Its clinical manifestations are highly variable depending on the organs and tissue affected and often require a high degree of clinical suspicion to achieve correct diagnosis. Development of proteomic tools, radioisotope scintigraphy, immunologic antibody targets by immunohistochemistry, immunofluorescence and microscopic techniques have improved the sensitivity of accurate detection of specific subtypes of amyloid proteins. Newer therapeutic targets have been developed to arrest or suppress the specific types of amyloid proteins, giving rise to the possibility of targeted therapy with better quality of life and improved survival benefits for patients. AL, ATTR, AA and ALECT2 are the major subtypes of amyloidosis and kidney, heart, soft tissue, and peripheral nerves are the most affected viscera. The key to achieving success in better quality of life and overall survival in patients, is in early diagnosis and accurate subtyping of amyloidosis.

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“…In China, this research is in its infancy and there are no similar results, though the country has spent manpower and material resources to carry out marine monitoring and investigation and the construction of a marine information system [9,10] in recent years. The organization and design of the obtained data and products are mainly set according to the nature of the discipline, without taking the ecosystem as a whole into consideration, and with the lack of description of the relationship between biology and environment and its temporal and spatial distribution pattern, it is impossible to have a comprehensive understanding of the marine ecosystem.…”

Section: Introductionmentioning

confidence: 99%

Study on the Expression of Spatiotemporal Patterns in Marine Ecosystems

Linchong

Huang

Jiang

et al. 2022

IOP Conf. Ser.: Earth Environ. Sci.

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The ocean is a three-dimensional ecosystem with a wide range of temporal and spatial scales, thus making the visual expression of marine ecological characteristics extremely challenging. What types of marine ecosystems exist in a region, where are they distributed, what is their current status, and what are their changing trends? These are important questions faced by marine managers and decision makers. Based on the analysis of the relationship between biology and environment, this paper conducts ecological classification and data production for various marine elements. This paper expresses spatiotemporal marine ecological characteristics using a four-level general framework, including sea zone, bathymetry space, water space, seabed space. The bathymetry reflects the relevant marine topographic and landscape characteristics, and the water space and seabed space are composed of water environment, sediment environment and living organisms respectively. The framework’s main functions are the display, description, and statistical analysis of ecological characteristics, and display the spatiotemporal distribution pattern. These methods were combined with the construction of a database and R&D of system functions to fill the gap in this field in China and provide decision support for marine ecosystem management.

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The World of 5G

Cited by 5 publications

References 0 publications

Hernandezine Regulates Proliferation and Autophagy-Induced Apoptosis in Melanoma Cells

Hernandezine Regulates Proliferation and Autophagy-Induced Apoptosis in Melanoma Cells

Diagnosis of Amyloidosis: Clinicopathological Advances and Challenges

Study on the Expression of Spatiotemporal Patterns in Marine Ecosystems

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