The World of Dementia Beyond 2020

Brodaty, Henry; Breteler, Monique M.B.; DeKosky, Steven T.; Dorenlot, Pascale; Fratiglioni, Laura; Höck, Christoph; Kenigsberg, Paul‐Ariel; Scheltens, Philip; Strooper, Bart De

doi:10.1111/j.1532-5415.2011.03365.x

Cited by 83 publications

(57 citation statements)

References 20 publications

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“…Given the higher prevalence of dementia in secondary and tertiary care settings, high number of undiagnosed patients, and new developing available treatment, early recognizing of dementia is crucial. [2][3][4][5][6] The most commonly used and studied test, which has acceptable accuracy is the Mini-Mental State Examination (MMSE). 2,4,[7][8][9] Its sensitivity varies from 71% to 92% and specificity ranges from 56% to 96% depending on the cutoff point used for an abnormal test.…”

Section: Introductionmentioning

confidence: 99%

Can Rowland Universal Dementia Assessment Scale (RUDAS) Replace Mini-Mental State Examination (MMSE) for Dementia Screening in a Thai Geriatric Outpatient Setting?

Limpawattana

Tiamkao

Sawanyawisuth

et al. 2012

Am J Alzheimers Dis Other Demen

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Mini-mental-State Examination (MMSE) is a widely used tool for dementia screening. However, several limitations are found and the Rowland Universal Dementia Assessment Scale (RUDAS) appears to be an alternative test. The objective in this study was to compare the performance of MMSE-Thai 2002 and RUDAS-Thai for dementia screening, and to determine their performances and identify their optimal cut-off points. The participants were older patients from a Geriatric and Neurology Outpatient Clinic, Srinagarind Hospital, Khon Kaen University. The RUDAS-Thai and the MMSE-Thai 2002 were administered to each participant. Subsequently, a specialist physician assessed each participant for dementia. Results showed the area under receiver operating characteristic curve for both RUDAS-Thai (81.0%; 95%CI, 74.8-87.2) and MMSE-Thai 2002 (81.2%; 95%CI, 74.9-87.4) were equal. A score of 24 or lower provided an optimal cut-off point. Our finding supports that the RUDAS-Thai can be an effective alternative test for dementia screening. For both test scores, a score of 24 or lower is an optimal cut-off point to provide an indication of developing dementia.

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Section: Introductionmentioning

confidence: 99%

Can Rowland Universal Dementia Assessment Scale (RUDAS) Replace Mini-Mental State Examination (MMSE) for Dementia Screening in a Thai Geriatric Outpatient Setting?

Limpawattana

Tiamkao

Sawanyawisuth

et al. 2012

Am J Alzheimers Dis Other Demen

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“…AD is a neurodegenerative condition that results in deterioration of memory and other cognitive functions and ultimately leads to death [1]. Approximately 35 million people worldwide are affected with dementia and this number is expected to reach 65 million in 2030 and 113 million by 2050 [2]. Dementia rates are expected to increase in the least developed and developing countries, as estimates suggest that 71% of the expected 81.1 million dementia cases will be in the developing world by 2040 [3].…”

Section: Introductionmentioning

confidence: 99%

Association of APOE polymorphisms and stressful life events with dementia in a Pakistani population

Chaudhry

Hasnain

Snitz

et al. 2014

Neuroscience Letters

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Dementia is a major public health problem worldwide. Alzheimer’s disease (AD) is a major form of dementia and the APOE*4 allele is an established genetic risk factor for AD. Similarly, stressful life events are also associated with dementia. The objective of this study was to examine the association of APOE*4 and stressful life events with dementia in a Pakistani sample, which to our knowledge has not been reported previously. We also tested for an interaction between stressful life events and APOE*4 on dementia risk. A total of 176 subjects (61 cases and 115 controls) were recruited. All cases and healthy controls were interviewed to assess cognition, co-morbidities, history of stressful life events and demographics. Blood genotyping for the APOE polymorphism (E2/E3/E4) was performed. APOE*4 and stressful life events were each independently and significantly associated with the risk of dementia (APOE*4: P=0.00697; stressful life events: P=5.29E-09). However, we did not find a significant interaction between APOE*4 carrier status and stressful life events on risk of dementia (P=0.677). Although the sample size of this study was small, the established association of APOE*4 with dementia was confirmed the first time in a Pakistani sample. Furthermore, stressful life events were also found to be significantly associated with dementia in this population.

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“…Thus, relatives have expressed the opinion that research for the improvement of quality of life of their relative with dementia should be supported but not research for prolonging life [36].…”

Section: Assessment Of Capacity To Consentmentioning

confidence: 99%

Research with dementia patients?

Helmchen

2015

Ethics, Medicine and Public Health

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The World of Dementia Beyond 2020

Cited by 83 publications

References 20 publications

Can Rowland Universal Dementia Assessment Scale (RUDAS) Replace Mini-Mental State Examination (MMSE) for Dementia Screening in a Thai Geriatric Outpatient Setting?

Can Rowland Universal Dementia Assessment Scale (RUDAS) Replace Mini-Mental State Examination (MMSE) for Dementia Screening in a Thai Geriatric Outpatient Setting?

Association of APOE polymorphisms and stressful life events with dementia in a Pakistani population

Research with dementia patients?

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