Multifunctional buildings have become more common in the last years. At the same time the threat from antagonistic attacks has increased. This presents challenges for the fire safety systems in multifunctional buildings since continuity of functions, especially those considered to be of societal importance, need to be operational and at the same time antagonistic exposures may present more challenging fire scenarios. A method for selection and evaluation of fire related scenarios in multifunctional buildings, that also considers antagonistic attacks, has been developed. Based on literature review and interviews with stakeholders typical for a multifunctional building, specific problem areas that the developed method needed to take into account were identified. A first framework for development of fire scenarios, developed by the authors in previous work, was refined taking into account the identified problem areas resulting in the method described in this article. The method, still simple to use, provides guidance on how to determine assets needing protection, relevant protection objectives, exposures (both accidental and antagonistic), fire related scenarios and evaluation of scenarios. The method also takes into account the inherent probability of failure for active systems, security features, domino effects and damage to protection systems due to antagonistic attacks.