The wound/burn guidelines – 1: Wounds in general

Inoue, Yoshio; Hasegawa, Minoru; Maekawa, Takeo; Pavoux, Andres Le; Asano, Yoshihide; Abe, Masatoshi; Ishii, Takayuki; Ito, Takaaki; Isei, Taiki; Imafuku, Shinichi; Irisawa, Ryokichi; Ohtsuka, Masaki; Ohtsuka, Mikio; Ogawa, Fumihide; Kadono, Takafumi; Kodera, Masanari; Kawakami, Tamihiro; Kawaguchi, Masakazu; Kukino, Ryuichi; Kono, Toru; Sakai, Keisuke; Takahara, Masakazu; Tanioka, Miki; Nakanishi, Takeshi; Nakamura, Yasuhiro; Hashimoto, Akira; Hayashi, Masahiro; Fujimoto, Manabu; Fujiwara, Hiroshi; Matsuo, Koma; Madokoro, Naoki; Yoshino, Yutaka; Tachibana, Takao; Ihn, Hironobu

doi:10.1111/1346-8138.13276

Cited by 9 publications

(4 citation statements)

References 61 publications

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“…The presence of microorganisms is the most common cause of delayed wound repair. The amount, growth, and virulence of hosted microorganisms determine the wound state and prognosis [1]. The release of antimicrobial compounds and phagocytosis by host cells is required for infection control [2].…”

Section: Introductionmentioning

confidence: 99%

Dialkyl Carbamoyl Chloride–Coated Dressing Prevents Macrophage and Fibroblast Stimulation via Control of Bacterial Growth: An In Vitro Assay

Ortega‐Peña

Chopin-Doroteo²,

Lara³

et al. 2022

Microorganisms

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In this work, we evaluated the direct effect of a dialkyl carbamoyl chloride (DACC)-coated dressing on Staphylococcus aureus adhesion and growth in vitro, as well as the indirect effect of the dressing on fibroblast and macrophage activity. S. aureus cultures were treated with the dressing or gauze in Müller-Hinton medium or serum-supplemented Dulbecco’s modified Eagle medium. Bacterial growth and attachment were assessed through colony-forming units (CFU) and residual biomass analyses. Fibroblast and macrophage co-cultures were stimulated with filtered supernatants from the bacterial cultures treated with the DACC-coated dressing, following which tumor necrosis factor (TNF)-α/transforming growth factor (TGF)-β1 expression and gelatinolytic activity were assessed by enzyme-linked immunosorbent assays (ELISA) and zymography, respectively. The DACC-coated dressing bound 1.8–6.1% of all of the bacteria in the culture. Dressing-treated cultures presented biofilm formation in the dressing (enabling mechanical removal), with limited formation outside of it (p < 0.001). Filtered supernatants of bacterial cultures treated with the DACC-coated dressing did not over-stimulate TNF-α or TGF-β1 expression (p < 0.001) or increase gelatinolytic activity in eukaryotic cells, suggesting that bacterial cell integrity was maintained. Based on the above data, wound caregivers should consider the use of hydrophobic dressings as a first option for the management of acute or chronic wounds.

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Section: Introductionmentioning

confidence: 99%

Dialkyl Carbamoyl Chloride–Coated Dressing Prevents Macrophage and Fibroblast Stimulation via Control of Bacterial Growth: An In Vitro Assay

Ortega‐Peña

Chopin-Doroteo²,

Lara³

et al. 2022

Microorganisms

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“…Many chronic wounds are inert, and the wound healing cascade appears to have stopped before properly entering the proliferation phase. 23 These chronic wounds have a higher pH in their ‘resting state’, which favours bacterial growth, closing the vicious circle and showing colonisation with a multitude of different stems of bacteria, further inhibiting wound healing. 22 , 24 With advanced wound healing, a wound's pH decreases towards more acidic, and the typical pH values of the surface of healed skin of 4 to 6.…”

Section: Discussionmentioning

confidence: 99%

“…We observed no significant reduction in wound size after the initial 4 weeks of treatment, with the ‘healing effect’ becoming apparent after another 4 weeks (8 weeks of treatment); however, given the small sample size, we could see an effect on wound size reduction of d = 0.449. Many chronic wounds are inert, and the wound healing cascade appears to have stopped before properly entering the proliferation phase 23 . These chronic wounds have a higher pH in their ‘resting state’, which favours bacterial growth, closing the vicious circle and showing colonisation with a multitude of different stems of bacteria, further inhibiting wound healing 22,24 .…”

Section: Discussionmentioning

confidence: 99%

The successful use of polylactide wound dressings for chronic lower leg wounds: A retrospective analysis

Nischwitz

Popp

Shubitidze³

et al. 2021

International Wound Journal

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Chronic wounds are a challenging medical entity for patients, medical professionals and healthcare systems. Frequently, patients present themselves to wound specialists after months or even years of unsuccessful treatment. Recent developments have resulted in a multitude of different advanced wound dressings created to treat complex, chronic wounds, one of which is the polylactide dressing Suprathel. This study aimed at investigating the healing potential of Suprathel in chronic wounds and differentiating between old and “young”, diabetic and non‐diabetic chronic wounds. A prospective, multicentric, non‐controlled intervention study was conducted, treating patients with chronic lower leg ulcers (>3 months) with Suprathel and assessing them weekly. Afterwards, a retrospective analysis was performed analysing the wound size initially, after 4 and after 8 weeks of treatment. Furthermore, a differentiation between diabetic and non‐diabetic, and chronic wounds older and younger than 12 months, was assessed. A significant reduction in wound size was observed in the study population after 8 weeks of treatment. The effect size in the diabetic wound and the old chronic wound group even reached more than one, with the other groups still showing a large effect of the intervention. This study shows that Suprathel is a valuable tool in the armamentarium of a wound specialist. Not only could we show a positive effect on chronic wounds, we could even demonstrate a significant wound size reduction in chronic wounds of old and young, as well as diabetic wounds, with the treatment of older chronic and diabetic wounds yielding an even larger effect size. Further randomised, controlled studies are necessary to show the full potential of advanced wound dressing materials in large patient cohorts.

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“…After the Ethics Committee approval, burns were treated successfully using tilapia skin as an occlusive dressing, which has gained worldwide attention (Lima Júnior et al, 2020, 2021. It allows tissue repair and serves as a physical barrier in addition to preventing dehydration, sepsis, and metabolic and functional complications (Boateng and Catanzano, 2015;Inoue et al, 2016;Lineen and Namias, 2008). The use of tilapia skin has transcended its application in burns and is also used in other soft tissue reconstructive surgeries, such as neovaginoplasty (Bezerra et al, 2018;Dias et al, 2020;Pinto Medeiros Dias et al, 2019) and male-to-female gender-affirming surgery (Rodríguez et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Nile tilapia skin (Oreochromis niloticus) for burn treatment: ultrastructural analysis and quantitative assessment of collagen

Verde¹,

Ferreira-Júnior²,

Silva³

et al. 2021

Acta Histochemica

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The wound/burn guidelines – 1: Wounds in general

Cited by 9 publications

References 61 publications

Dialkyl Carbamoyl Chloride–Coated Dressing Prevents Macrophage and Fibroblast Stimulation via Control of Bacterial Growth: An In Vitro Assay

Dialkyl Carbamoyl Chloride–Coated Dressing Prevents Macrophage and Fibroblast Stimulation via Control of Bacterial Growth: An In Vitro Assay

The successful use of polylactide wound dressings for chronic lower leg wounds: A retrospective analysis

Nile tilapia skin (Oreochromis niloticus) for burn treatment: ultrastructural analysis and quantitative assessment of collagen

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