The Wound-Healing Effect of Mango Peel Extract on Incision Wounds in a Murine Model

Abstract

Mangifera indica can generate up to 60% of polluting by-products, including peels. However, it has been shown that flavonoids and mangiferin are mainly responsible for the antioxidant, anti-inflammatory, and antibacterial activities closely related to the wound-healing process. The chemical composition of MEMI (methanolic extract of M. indica) was analyzed by HPLC-DAD, as well as concentrations of total phenol (TPC) and flavonoids (TFC) and antioxidant activity (SA50). Wound-healing efficacy was determined by measurements of wound contraction, histological analysis, and tensiometric method; moreover, anti-inflammatory, antibacterial, and acute dermal toxicity (OECD 402) were also evaluated. Phenol, resorcinol, conjugated resorcinol, and mangiferin were detected. TPC, TFC, and SA50 were 136 mg GAE/g, 101.66 mg QE/g, and 36.33 µg/mL, respectively. Tensile strength and wound contraction closure did not show significant differences between MEMI and dexpanthenol groups. Histological analysis (after 14 days) shows a similar architecture between MEMI treatment and normal skin. MEMI exhibits a reduction in edema. Staphylococcus epidermidis had an MIC of 2 mg/mL, while Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli reached 4 mg/mL. The MEMI showed no signs of toxicity. Therefore, this study demonstrates multiple targets that flavonoids and mangiferin of MEMI may present during the healing process.

Utilisation of Mangifera indica plant extracts and parts in antimicrobial formulations and as a pharmaceutical excipient: a review

“…Espinosa-Espinosa et al [ 58 ] researched the effect of methanol extract of M. indica peel on incision wounds in a murine model using 5% dexpanthenol as positive control. According to the researchers, the incision model was used to assess the healing efficiency of the plant extract.…”

Film dressings from Thai mango seed kernel extracts versus nanocrystalline silver dressings in antibacterial properties

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Wound Healing Properties of Natural Products: Mechanisms of Action

“…Extracts rich in phenolic compounds from Diospyros mespiliformis , Haplophyllum tuberculatum, and Mangifera indica showed important antioxidant, anti-inflammatory, and antimicrobial activities when evaluated in different models of wound healing [ 106 , 107 , 108 ]. Rocha et al [ 109 ] evaluated the antioxidant, anti-inflammatory, and healing activities of Artemisia campestris L. hydrodistillation residual water and its essential oil, finding that the residual hydrodistillation water showed promising antioxidant and anti-inflammatory activities without causing toxicity in the macrophages and fibroblasts.…”