2023
DOI: 10.1101/2023.08.08.552342
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The X-Linked Intellectual Disability gene,ZDHHC9, is important for oligodendrocyte subtype determination and myelination

Abstract: Two percent of all patients with X-linked intellectual disability (XLID) exhibit loss-of-function mutations in the palmitoylating enzyme, ZDHHC9. One of the main anatomical deficits observed in these patients is a decrease in corpus callosum volume and a disruption of white matter integrity. We demonstrated that ablation of Zdhhc9 in mice substantially impairs the maturation of oligodendrocytes, resulting in fewer mature, myelinating oligodendrocytes, higher numbers of oligodendrocyte progenitor cells and a de… Show more

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