The XOR-IDH3α axis controls macrophage polarization in hepatocellular carcinoma

Lu, Yijun; Sun, Q.; Guan, Qingpei; Zhang, Zechuan; He, Qifeng; He, Jianbo; Ji, Zetao; Tian, Wen‐de; Xu, Xun; Liu, Yang; Yin, Yin; Zheng, Chang; Lian, Senlin; Xu, Bing; Wang, Pin; Jiang, Runqiu; Sun, Beicheng

doi:10.1016/j.jhep.2023.06.022

Cited by 10 publications

(2 citation statements)

References 36 publications

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“…As an intricate malignancy, HCC is characterized by metabolic reprogramming, in which glycolytic and lipid metabolism aberrations can contribute to an immunosuppressive TME. The implicated metabolic regulators include XOR ( 88 ), SCD1 ( 89 ), and ACLY ( 90 ). Finally, transcription factors involved in regulating cancer stemness in HCC, such as SALL4 ( 80 ) and FOXM1 ( 91 ), are known to exert immunosuppressive effects on the TME of HCC.…”

Section: General Concept Of Cancer Stem Cellsmentioning

confidence: 99%

The roles of cancer stem cell-derived secretory factors in shaping the immunosuppressive tumor microenvironment in hepatocellular carcinoma

Muliawan,

Lee

2024

Front. Immunol.

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Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies worldwide and has a poor prognosis. Although immune checkpoint inhibitors have entered a new era of HCC treatment, their response rates are modest, which can be attributed to the immunosuppressive tumor microenvironment within HCC tumors. Accumulating evidence has shown that tumor growth is fueled by cancer stem cells (CSCs), which contribute to therapeutic resistance to the above treatments. Given that CSCs can regulate cellular and physical factors within the tumor niche by secreting various soluble factors in a paracrine manner, there have been increasing efforts toward understanding the roles of CSC-derived secretory factors in creating an immunosuppressive tumor microenvironment. In this review, we provide an update on how these secretory factors, including growth factors, cytokines, chemokines, and exosomes, contribute to the immunosuppressive TME, which leads to immune resistance. In addition, we present current therapeutic strategies targeting CSC-derived secretory factors and describe future perspectives. In summary, a better understanding of CSC biology in the TME provides a rational therapeutic basis for combination therapy with ICIs for effective HCC treatment.

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Section: General Concept Of Cancer Stem Cellsmentioning

confidence: 99%

The roles of cancer stem cell-derived secretory factors in shaping the immunosuppressive tumor microenvironment in hepatocellular carcinoma

Muliawan,

Lee

2024

Front. Immunol.

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“…The reason why tumors can escape the immune surveillance of the body is principally because they can produce excessive immunosuppressive factors, resulting in poor antitumor immune function in patients, which is not enough to produce a strong antitumor immune response to clear tumor cells ( 8 – 10 ). Therefore, the immunosuppressive microenvironment of HCC can provide a favorable condition for tumor growth, and immunotherapy is one of the effective methods to inhibit HCC growth ( 11 ).…”

Section: Introductionmentioning

confidence: 99%

Antitumor immunostimulatory activity of the traditional Chinese medicine polysaccharide on hepatocellular carcinoma

Liu,

Wu,

Hao

2024

Front. Immunol.

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Hepatocellular carcinoma (HCC) is a prevalent malignancy, often associated with compromised immune function in affected patients. This can be attributed to the secretion of specific factors by liver cancer cells, which hinder the immune response and lead to a state of immune suppression. Polysaccharides derived from traditional Chinese medicine (TCM) are valuable constituents known for their immunomodulatory properties. This review aims to look into the immunomodulatory effects of TCM polysaccharides on HCC. The immunomodulatory effects of TCM polysaccharides are primarily manifested through the activation of effector T lymphocytes, dendritic cells, NK cells, and macrophages against hepatocellular carcinoma (HCC) both in vivo and in vitro settings. Furthermore, TCM polysaccharides have demonstrated remarkable adjuvant antitumor immunomodulatory effects on HCC in clinical settings. Therefore, the utilization of TCM polysaccharides holds promising potential for the development of novel therapeutic agents or adjuvants with advantageous immunomodulatory properties for HCC.

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PdZn/Co_SA‐NC Nanozymes with Highly Efficient SOD/CAT Activities for Treatment of Osteoarthritis via Regulating Immune Microenvironment

Yang,

Tan,

Guo

et al. 2024

Adv Funct Materials

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Inflammatory infiltration of synovial M1 macrophages, high levels of ROS, and NO exacerbate osteoarthritis (OA) progression. The PdZn/CoSA‐NC nanozymes, which are highly ordered PdZn intermetallic nanoparticles loaded with Co single atom N‐doped carbon‐rich in multi‐level pores, in an attempt to serve as SOD and CAT mimicking nanozymes for OA therapy is designed. The PdZn/CoSA‐NC nanozymes' high electron transfer and dual active site sufficient exposure enhances free radical adsorption and lower reaction energies, accelerating SOD‐like, CAT‐like, and GPx‐like catalyzed reactions, outperforming CoSA‐NC and PdZn/NC alone. Furthermore, PdZn/CoSA‐NC nanozymes exhibit favorable biocompatibility, reduce synovial macrophage oxidative stress in OA, alleviate hypoxia, restore mitochondrial function, regulate energy metabolism, increase antioxidant factors, and reduce inflammatory factors, thus effectively mitigating the progression of OA. Mechanistically, PdZn/CoSA‐NC nanozymes downregulate M1‐type phenotypic markers like IL‐1β by regulating purine metabolism. The PdZn/CoSA‐NC nanozymes offer a novel approach to treating oxidative stress‐related inflammatory diseases.

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The XOR-IDH3α axis controls macrophage polarization in hepatocellular carcinoma

Cited by 10 publications

References 36 publications

The roles of cancer stem cell-derived secretory factors in shaping the immunosuppressive tumor microenvironment in hepatocellular carcinoma

The roles of cancer stem cell-derived secretory factors in shaping the immunosuppressive tumor microenvironment in hepatocellular carcinoma

Antitumor immunostimulatory activity of the traditional Chinese medicine polysaccharide on hepatocellular carcinoma

PdZn/Co_SA‐NC Nanozymes with Highly Efficient SOD/CAT Activities for Treatment of Osteoarthritis via Regulating Immune Microenvironment

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The XOR-IDH3α axis controls macrophage polarization in hepatocellular carcinoma

Cited by 10 publications

References 36 publications

The roles of cancer stem cell-derived secretory factors in shaping the immunosuppressive tumor microenvironment in hepatocellular carcinoma

The roles of cancer stem cell-derived secretory factors in shaping the immunosuppressive tumor microenvironment in hepatocellular carcinoma

Antitumor immunostimulatory activity of the traditional Chinese medicine polysaccharide on hepatocellular carcinoma

PdZn/CoSA‐NC Nanozymes with Highly Efficient SOD/CAT Activities for Treatment of Osteoarthritis via Regulating Immune Microenvironment

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Product

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PdZn/Co_SA‐NC Nanozymes with Highly Efficient SOD/CAT Activities for Treatment of Osteoarthritis via Regulating Immune Microenvironment