The Year in Review: Surgical Revascularization of Coronary Artery Disease-2011

Lazar, Harold L.

doi:10.1111/j.1540-8191.2012.01451.x

Journal of Cardiac Surgery

2012

DOI: 10.1111/j.1540-8191.2012.01451.x

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The Year in Review: Surgical Revascularization of Coronary Artery Disease-2011

Harold L. Lazar

Abstract: Important studies highlighting the practice of coronary artery bypass surgery for 2011 are reviewed.

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The use of shear stress for targeted drug delivery

Saxer

Müller

2013

Cardiovascular Research

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Stenosed segments of arteries significantly alter the blood flow known from healthy vessels. In particular, the wall shear stress at critically stenosed arteries is at least an order of magnitude higher than in healthy situations. This alteration represents a change in physical force and might be used as a trigger signal for drug delivery. Mechano-sensitive drug delivery systems that preferentially release their payload under increased shear stress are discussed. Therefore, besides biological or chemical markers, physical triggers are a further principle approach for targeted drug delivery. We hypothesize that such a physical trigger is much more powerful to release drugs for vasodilation, plaque stabilization, or clot lysis at stenosed arteries than any known biological or chemical ones.

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The use of shear stress for targeted drug delivery

Saxer

Müller

2013

Cardiovascular Research

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show abstract

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The Year in Review: Surgical Revascularization of Coronary Artery Disease-2011

Abstract: Important studies highlighting the practice of coronary artery bypass surgery for 2011 are reviewed.

Cited by 1 publication

References 64 publications

The use of shear stress for targeted drug delivery

The use of shear stress for targeted drug delivery

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