2018
DOI: 10.1111/sji.12705
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The yin‐yang of the interaction between myelomonocytic cells and NK cells

Abstract: NK cells are innate lymphoid cells, which play a key role in the immune response to cancer and pathogens and participate in the shaping of adaptive immunity. NK cells engage in a complex bidirectional interaction with myelomonocytic cells. In particular, macrophages, dendritic cells and neutrophils promote differentiation and effector function of NK cells and, on the other hand, myelomonocytic cells express triggers of checkpoint blockade (eg PD-L1) and other immunosuppressive molecules, which negatively regul… Show more

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Cited by 41 publications
(33 citation statements)
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References 111 publications
(261 reference statements)
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“…This study has proved that BFQW had a better therapeutic effect in patients with COVID-19. Network pharmacology analysis of BFQW bioactive ingredients-targets-disease was constructed to illustrate the key targets and potential mechanism (Molgora et al,2018). Six active ingredients and 13 targets were predicted to explain the possible mechanism of BFQW on COVID-19.…”
Section: Discussionmentioning
confidence: 99%
“…This study has proved that BFQW had a better therapeutic effect in patients with COVID-19. Network pharmacology analysis of BFQW bioactive ingredients-targets-disease was constructed to illustrate the key targets and potential mechanism (Molgora et al,2018). Six active ingredients and 13 targets were predicted to explain the possible mechanism of BFQW on COVID-19.…”
Section: Discussionmentioning
confidence: 99%
“…NK cells can mediate direct killing upon interaction with foreign pathogens or cells exhibiting signs of stress, but they are also the primary effector cells in mediating antibodydependent cellular cytotoxicity (ADCC) via their Fcγ receptor (CD16) (26,95). The cytotoxic effect is executed through the release of perforins which allows secreted cytotoxic granzymes to enter the targeted cell (96). The analogous anti-viral effector function of activated macrophages is that of phagocytosis, where the macrophage will devour entire infected cells (96).…”
Section: Immunomodulatory Properties Of Tlr Agonistsmentioning
confidence: 99%
“…The cytotoxic effect is executed through the release of perforins which allows secreted cytotoxic granzymes to enter the targeted cell (96). The analogous anti-viral effector function of activated macrophages is that of phagocytosis, where the macrophage will devour entire infected cells (96). This effect can, like ADCC, be enhanced by antibodies and is thus called antibody-dependent cellular phagocytosis (ADCP).…”
Section: Immunomodulatory Properties Of Tlr Agonistsmentioning
confidence: 99%
“…Adaptive T cell‐orchestrated immunity and its subversion are central in the control of carcinogenesis and progression. Recent results have shed new light on the long‐overlooked role of innate lymphoid cells (ILC) . NK cells are a population of ILCs which has not been credited to play a major role in resistance against solid tumour carcinogenesis.…”
Section: Novel Checkpoints In Innate Immunitymentioning
confidence: 99%