2013
DOI: 10.1371/journal.pone.0079316
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The Zinc Transporter, Slc39a7 (Zip7) Is Implicated in Glycaemic Control in Skeletal Muscle Cells

Abstract: Dysfunctional zinc signaling is implicated in disease processes including cardiovascular disease, Alzheimer's disease and diabetes. Of the twenty-four mammalian zinc transporters, ZIP7 has been identified as an important mediator of the ‘zinc wave’ and in cellular signaling. Utilizing siRNA targeting Zip7 mRNA we have identified that Zip7 regulates glucose metabolism in skeletal muscle cells. An siRNA targeting Zip7 mRNA down regulated Zip7 mRNA 4.6-fold (p = 0.0006) when compared to a scramble control. This w… Show more

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Cited by 63 publications
(67 citation statements)
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“…Fig. S4A), which is in agreement with a role for this transporter in glycemic control of skeletal muscles [46]. A modest increase in Zip9 and ZnT10 transcript levels was observed (Supp.…”
Section: Resultssupporting
confidence: 85%
See 1 more Smart Citation
“…Fig. S4A), which is in agreement with a role for this transporter in glycemic control of skeletal muscles [46]. A modest increase in Zip9 and ZnT10 transcript levels was observed (Supp.…”
Section: Resultssupporting
confidence: 85%
“…Other ZIPs participate in Zn transport for protein maturation, a process that occurs in intracellular compartments. ZIP7, as an example, is located in the endoplasmic reticulum (ER) and the trans Golgi network (TGN), and it has an important role in glycemic control of skeletal muscle [46]. ZIP9 is located at the cell surface and TGN [47,48] and is considered to be an androgen receptor in addition to its role in Zn transport [48].…”
Section: Introductionmentioning
confidence: 99%
“…We identified that 10 nM of insulin was sufficient to induce the phosphorylation of AKT after 30 min of treatment and that this phosphorylation was transient and rapidly declined post 2 h. This is supported by several studies that demonstrated that insulin resistant could be measured by the amount of pAKT relative to total AKT protein over time with chronic insulin treatment [12][13][14][15]. Thus, reduced pAKT levels are consistent with an increase in insulin resistance.…”
Section: Discussionsupporting
confidence: 57%
“…The function of ZIP7 to elicit a rapid increase in cytosolic zinc is related to the propagation of cellular signalling pathways, specifically those reliant on the phosphorylation of Akt and extracellular signal-regulated kinases 1/2 (ERK-1/2). A recent study, which used siRNA to silence ZIP7 expression in a skeletal muscle cell line, found that both basal and insulin-stimulated glucose metabolism are compromised as a result of reduced ZIP7 expression (Myers et al 2013). Due to the crucial role of ZIP7 in glycolysis, the authors suggest that this zinc transporter may present as a molecular target in the treatment of insulin resistance within skeletal muscles.…”
Section: Discussionmentioning
confidence: 99%