The α-amylase and α-glucosidase inhibitory effects of some traditional antidiabetic prescriptions based on bioautography using LC-ESI/MSMS

Al-Baidhani, Rasha; Rezadoost, Hassan; Hamidi, Amin; Motevali, Seyed Mohammad; Mirzajani, Fateme

doi:10.52547/jmp.21.81.33

J. Med. Plants

2022

DOI: 10.52547/jmp.21.81.33

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The α-amylase and α-glucosidase inhibitory effects of some traditional antidiabetic prescriptions based on bioautography using LC-ESI/MSMS

Rasha Al-Baidhani

Hassan Rezadoost

Amin Hamidi

et al.

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2024

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Effects of MRI magnetic iron oxide nanoparticles on the structural and enzymatic properties of liver-related enzymes

Mirzajani,

Rostamzadeh,

Tahmasian

et al. 2024

Micro and Nano Syst Lett

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Cancer survivors undergo meticulous examinations, including regular magnetic resonance imaging (MRI) scans, to monitor the risk of disease recurrence. The use of magnetic iron nanoparticles (MNPs) enhances MRI accuracy. However, post-injection, MNPs exhibit a notable affinity for binding with proteins and biomolecules, forming a dynamic protein coating called a protein corona (CORONA). While there are reports of its elimination in the liver and kidney metabolism system, patients undergoing this method have shown symptoms of liver problems and related enzyme alterations. This study aims to discern whether the impact of MNPs on liver enzymes significantly contributes to liver damage. The investigation focuses on the effects of magnetic nanoparticles (MNPs) on selected enzymes, including alanine aminotransferase (ALT), aspartate transaminase (AST), α-amylase, and lipase. Employing 104 experiments over a central composite design (CCD), the study evaluates the effects of agents on MNP and enzyme structure, stability, and properties: enzyme assay, electron microscopy, and circular dichroism of secondary structure after interaction with MNPs. The study’s findings unveil the intricate relationship between MNPs and liver enzymes, providing valuable insights for clinical practices and refining the safety profile of MRI. This comprehensive exploration contributes to our understanding of potential implications and aids in optimizing the use of MNPs in medical imaging for cancer survivors.

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Effects of MRI magnetic iron oxide nanoparticles on the structural and enzymatic properties of liver-related enzymes

Mirzajani,

Rostamzadeh,

Tahmasian

et al. 2024

Micro and Nano Syst Lett

View full text Add to dashboard Cite

show abstract

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The α-amylase and α-glucosidase inhibitory effects of some traditional antidiabetic prescriptions based on bioautography using LC-ESI/MSMS

Cited by 1 publication

References 19 publications

Effects of MRI magnetic iron oxide nanoparticles on the structural and enzymatic properties of liver-related enzymes

Effects of MRI magnetic iron oxide nanoparticles on the structural and enzymatic properties of liver-related enzymes

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