The α<sub>1L</sub>‐adrenoceptor subtype in the lower urinary tract: a comparison of human urethra and prostate

Fukasawa,; Taniguchi,; Moriyama,; Ukai,; Yamazaki,; Ueki,; Kameyama,; Kimura,; Kawabe,

doi:10.1046/j.1464-410x.1998.00845.x

“…Four subtypes of α1-ARs (α1A, α1B, α1C, and α1L) have been identified in human prostate cells (7)(8)(9)(10)(11). These receptors are mostly localized in the fibromuscular stroma, where they mediate the contraction of prostate smooth muscle (8).…”

Section: Discussionmentioning

confidence: 99%

α1-adrenergic receptors activate Ca2+-permeable cationic channels in prostate cancer epithelial cells

Thebault¹,

Roudbaraki²,

Sydorenko³

et al. 2003

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. Y. Shuba's present address is: Bogomoletz Institute of Physiology, Kiev, Ukraine. Conflict of interest:The authors have declared that no conflict of interest exists. Nonstandard abbreviations used: α1-adrenergic receptor (α1-AR); human prostate cancer epithelial cell (hPCE cell); phospholipase C (PLC); inositol triphosphate (IP3); diacylglycerol (DAG); transient receptor potential (TRP); α1A subtype of α1-AR (α1A-AR); lymph node carcinoma of the prostate cells (LNCaP cells); intracellular Ca 2+ concentration ([Ca 2+ ]i); phenylephrine (Phe); intracellular Ca 2+ oscillations (osc); 2-aminophenyl borate (2-APB); store-operated Ca 2+ -channel (SOC); 1-oleoyl-2-acetyl-snglycerol (OAG); 1,2-dioctanoyl-sn-glycerol (DOG); extracellular Ca 2+ concentration ([Ca 2+ ]out); Phe-activated current (IPhe); current reversal potential (Erev).

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“…However, other authors have found that contractions of rat vas deferens to exogenous agonists are mediated by a1A-adrenoceptors as demonstrated by the very significant correlation with a1A-adrenoceptor ligand binding sites [71]. a1L-Adrenoceptors have also been reported in rabbit cutaneous resistance arteries (predominant adrenoceptor is a1B: [72]), rat small mesenteric artery [73], pig prostatic small arteries [74], guinea-pig aorta [75], rabbit iris [76], pig internal anal sphincter [54], rabbit bladder neck [77], in human, rat and dog urethra, dog and mouse prostate, but not in human prostate [58,78,79]. In contrast, Muramatsu et al [67] reported a1L-adrenoceptors in human prostate.…”

Section: A1l-adrenoceptors: A1a-adrenoceptorsmentioning

confidence: 99%

Subtypes of functional α1-adrenoceptor

Docherty

¹

2009

Cell. Mol. Life Sci.

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In this review, subtypes of functional alpha1-adrenoceptor are discussed. These are cell membrane receptors, belonging to the seven-transmembrane-spanning G-protein-linked family of receptors, which respond to the physiological agonist noradrenaline. alpha1-Adrenoceptors can be divided into alpha1A-, alpha1B- and alpha1D-adrenoceptors, all of which mediate contractile responses involving Gq/11 and inositol phosphate turnover. A fourth alpha1-adrenoceptor, the alpha1L-, represents a functional phenotype of the alpha1A-adrenoceptor. alpha1-Adrenoceptor subtype knock-out mice have refined our knowledge of the functions of alpha-adrenoceptor subtypes, particuarly as subtype-selective agonists and antagonists are not available for all subtypes. alpha1-Adrenoceptors function as stimulatory receptors involved particularly in smooth muscle contraction, especially contraction of vascular smooth muscle, both in local vasoconstriction and in the control of blood pressure and temperature, and contraction of the prostate and bladder neck. Central actions are now being elucidated.

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“…Among α1-AR subtypes, α1A is believed to be predominant in the fibromuscular stroma of the prostate (7)(8)(9)(10)(11). Its stimulation leads principally to the activation of phospholipase C (PLC), ultimately resulting in an increase in intracellular free Ca 2+ via inositol triphosphate (IP 3 ) and diacylglycerol (DAG) production (12,13).…”

Section: Introductionmentioning

confidence: 99%

α1-adrenergic receptors activate Ca2+-permeable cationic channels in prostate cancer epithelial cells

Thebault¹,

Roudbaraki²,

Sydorenko³

et al. 2003

View full text Add to dashboard Cite

. Y. Shuba's present address is: Bogomoletz Institute of Physiology, Kiev, Ukraine. Conflict of interest:The authors have declared that no conflict of interest exists. Nonstandard abbreviations used: α1-adrenergic receptor (α1-AR); human prostate cancer epithelial cell (hPCE cell); phospholipase C (PLC); inositol triphosphate (IP3); diacylglycerol (DAG); transient receptor potential (TRP); α1A subtype of α1-AR (α1A-AR); lymph node carcinoma of the prostate cells (LNCaP cells); intracellular Ca 2+ concentration ([Ca 2+ ]i); phenylephrine (Phe); intracellular Ca 2+ oscillations (osc); 2-aminophenyl borate (2-APB); store-operated Ca 2+ -channel (SOC); 1-oleoyl-2-acetyl-snglycerol (OAG); 1,2-dioctanoyl-sn-glycerol (DOG); extracellular Ca 2+ concentration ([Ca 2+ ]out); Phe-activated current (IPhe); current reversal potential (Erev).

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The α_1L‐adrenoceptor subtype in the lower urinary tract: a comparison of human urethra and prostate

Abstract: The alpha1L-adrenoceptor subtype is more prominent in the human, rabbit and dog urethra and dog prostate than in the human prostate.

Cited by 22 publications

References 20 publications

α1-adrenergic receptors activate Ca2+-permeable cationic channels in prostate cancer epithelial cells

α1-adrenergic receptors activate Ca2+-permeable cationic channels in prostate cancer epithelial cells

Subtypes of functional α1-adrenoceptor

α1-adrenergic receptors activate Ca2+-permeable cationic channels in prostate cancer epithelial cells

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The α1L‐adrenoceptor subtype in the lower urinary tract: a comparison of human urethra and prostate

Abstract: The alpha1L-adrenoceptor subtype is more prominent in the human, rabbit and dog urethra and dog prostate than in the human prostate.

Cited by 22 publications

References 20 publications

α1-adrenergic receptors activate Ca2+-permeable cationic channels in prostate cancer epithelial cells

α1-adrenergic receptors activate Ca2+-permeable cationic channels in prostate cancer epithelial cells

Subtypes of functional α1-adrenoceptor

α1-adrenergic receptors activate Ca2+-permeable cationic channels in prostate cancer epithelial cells

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Product

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The α_1L‐adrenoceptor subtype in the lower urinary tract: a comparison of human urethra and prostate