The β-adrenergic antagonist propranolol partly abolishes thermogenic response to bioactive food ingredients

Belza, Anita; Gille, Maj-Britt; John, Sarah; Kondrup, Jens

doi:10.1016/j.metabol.2009.03.013

Cited by 8 publications

(5 citation statements)

References 58 publications

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“…Use of a pharmacological SNS-blocking agent (e.g. the β-adrenergic antagonist propranolol) could help clarify this ( 13 ) .…”

Section: Discussionmentioning

confidence: 99%

“…One of the best studied of the pungent spices is chilli peppers ( 3 , 4 , 8 – 10 ) . Studies have shown that the pungent component, capsaicin, in chilli peppers can increase thermogenesis in both animals ( 11 , 12 ) and human subjects ( 3 , 4 ) , although the evidence is not consistent ( 4 , 13 , 14 ) . According to the evidence from rat studies, it seems that this capsaicin-induced increase in thermogenesis is due to the stimulation of catecholamine secretion from the adrenal medulla primarily through the sympathetic activation of the central nervous system ( 15 , 16 ) .…”

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confidence: 99%

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Acute effects of mustard, horseradish, black pepper and ginger on energy expenditure, appetite,ad libitumenergy intake and energy balance in human subjects

et al. 2012

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Chilli peppers have been shown to enhance diet-induced thermogenesis (DIT) and reduce energy intake (EI) in some studies, but there are few data on other pungent spices. The primary aim of the present study was to test the acute effects of black pepper (pepper), ginger, horseradish and mustard in a meal on 4 h postprandial DIT. The secondary aim was to examine the effects on subjective appetite measures, ad libitum EI and energy balance. In a five-way placebo-controlled, single-blind, cross-over trial, twenty-two young (age 24·9 (SD 4·6) years), normal-weight (BMI 21·8 (SD 2·1) kg/m 2 ) males were randomly assigned to receive a brunch meal with either pepper (1·3 g), ginger (20 g), horseradish (8·3 g), mustard (21 g) or no spices (placebo). The amounts of spices were chosen from pre-testing to make the meal spicy but palatable. No significant treatment effects were observed on DIT, but mustard produced DIT, which tended to be larger than that of placebo (14 %, 59 (SE 3) v. 52 (SE 2) kJ/h, respectively, P¼0·08). No other spice induced thermogenic effects approaching statistical significance. Subjective measures of appetite (P.0·85), ad libitum EI (P¼ 0·63) and energy balance (P¼0·67) also did not differ between the treatments. Finally, horseradish decreased heart rate (P¼ 0·048) and increased diastolic blood pressure (P¼0·049) compared with placebo. In conclusion, no reliable treatment effects on appetite, EI or energy balance were observed, although mustard tended to be thermogenic at this dose. Further studies should explore the possible strength and mechanisms of the potential thermogenic effect of mustard actives, and potential enhancement by, for example, combinations with other food components.

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“…Use of a pharmacological SNS-blocking agent (e.g. the β-adrenergic antagonist propranolol) could help clarify this ( 13 ) .…”

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Acute effects of mustard, horseradish, black pepper and ginger on energy expenditure, appetite,ad libitumenergy intake and energy balance in human subjects

et al. 2012

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“…Human studies have shown that capsaicin increased the diet-induced thermogenesis [3], [4], [10]. Both human and animal studies investigated the effect of capsaicin after administration of β-adrenergic blockers such as propranolol, and showed that the thermogenic effect of capsaicin is reduced after administration of beta-adrenergic blockers [12], [15]. This implies that the increased thermogenesis by capsaicin is probably based on β-adrenergic stimulation.…”

Section: Introductionmentioning

confidence: 99%

Acute Effects of Capsaicin on Energy Expenditure and Fat Oxidation in Negative Energy Balance

et al. 2013

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BackgroundAddition of capsaicin (CAPS) to the diet has been shown to increase energy expenditure; therefore capsaicin is an interesting target for anti-obesity therapy.AimWe investigated the 24 h effects of CAPS on energy expenditure, substrate oxidation and blood pressure during 25% negative energy balance.MethodsSubjects underwent four 36 h sessions in a respiration chamber for measurements of energy expenditure, substrate oxidation and blood pressure. They received 100% or 75% of their daily energy requirements in the conditions ‘100%CAPS’, ‘100%Control’, ‘75%CAPS’ and ‘75%Control’. CAPS was given at a dose of 2.56 mg (1.03 g of red chili pepper, 39,050 Scoville heat units (SHU)) with every meal.ResultsAn induced negative energy balance of 25% was effectively a 20.5% negative energy balance due to adapting mechanisms. Diet-induced thermogenesis (DIT) and resting energy expenditure (REE) at 75%CAPS did not differ from DIT and REE at 100%Control, while at 75%Control these tended to be or were lower than at 100%Control (p = 0.05 and p = 0.02 respectively). Sleeping metabolic rate (SMR) at 75%CAPS did not differ from SMR at 100%CAPS, while SMR at 75%Control was lower than at 100%CAPS (p = 0.04). Fat oxidation at 75%CAPS was higher than at 100%Control (p = 0.03), while with 75%Control it did not differ from 100%Control. Respiratory quotient (RQ) was more decreased at 75%CAPS (p = 0.04) than at 75%Control (p = 0.05) when compared with 100%Control. Blood pressure did not differ between the four conditions.ConclusionIn an effectively 20.5% negative energy balance, consumption of 2.56 mg capsaicin per meal supports negative energy balance by counteracting the unfavorable negative energy balance effect of decrease in components of energy expenditure. Moreover, consumption of 2.56 mg capsaicin per meal promotes fat oxidation in negative energy balance and does not increase blood pressure significantly.Trial RegistrationNederlands Trial Register; registration number NTR2944

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“…Oral capsaicin enhanced satiety and diminished calorie and fat intake [279]. In another report with 19 overweight to obese men, a supplement containing capsaicin increased energy expenditure in comparison to placebo [305]; these findings were supported by further studies [306][307][308][309][310]. The use of capsaicin 1h prior to low intensity exercise was also shown to improve lipolysis in healthy volunteers [242].…”

Section: Clinical Perspectivesmentioning

confidence: 88%

An Overview of the TRP-Oxidative Stress Axis in Metabolic Syndrome: Insights for Novel Therapeutic Approaches

Araújo¹,

Soczek

Pontes

et al. 2022

Cells

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Metabolic syndrome (MS) is a complex pathology characterized by visceral adiposity, insulin resistance, arterial hypertension, and dyslipidaemia. It has become a global epidemic associated with increased consumption of high-calorie, low-fibre food and sedentary habits. Some of its underlying mechanisms have been identified, with hypoadiponectinemia, inflammation and oxidative stress as important factors for MS establishment and progression. Alterations in adipokine levels may favour glucotoxicity and lipotoxicity which, in turn, contribute to inflammation and cellular stress responses within the adipose, pancreatic and liver tissues, in addition to hepatic steatosis. The multiple mechanisms of MS make its clinical management difficult, involving both non-pharmacological and pharmacological interventions. Transient receptor potential (TRP) channels are non-selective calcium channels involved in a plethora of physiological events, including energy balance, inflammation and oxidative stress. Evidence from animal models of disease has contributed to identify their specific contributions to MS and may help to tailor clinical trials for the disease. In this context, the oxidative stress sensors TRPV1, TRPA1 and TRPC5, play major roles in regulating inflammatory responses, thermogenesis and energy expenditure. Here, the interplay between these TRP channels and oxidative stress in MS is discussed in the light of novel therapies to treat this syndrome.

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The β-adrenergic antagonist propranolol partly abolishes thermogenic response to bioactive food ingredients

Cited by 8 publications

References 58 publications

Acute effects of mustard, horseradish, black pepper and ginger on energy expenditure, appetite,ad libitumenergy intake and energy balance in human subjects

Acute effects of mustard, horseradish, black pepper and ginger on energy expenditure, appetite,ad libitumenergy intake and energy balance in human subjects

Acute Effects of Capsaicin on Energy Expenditure and Fat Oxidation in Negative Energy Balance

An Overview of the TRP-Oxidative Stress Axis in Metabolic Syndrome: Insights for Novel Therapeutic Approaches

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