The ε4 genotype of apolipoprotein E and white matter integrity in Alzheimer's disease

Abstract

The results indicate that APOE ε4 has a moderate effect on WM integrity in HCs, but no effect on WM integrity in manifest AD.

Structural Connectivity Changes Underlying Altered Working Memory Networks in Mild Cognitive Impairment: A Three‐Way Image Fusion Analysis

“…27 All healthy control subjects scored 0 in the CDR rating. 28 In the AD/MCI group, four subjects carried at least one ApoE4 allele, in the control group one subject carried one ApoE4 allele (not significantly different between groups, Fisher's exact test, P = .32). Furthermore we examined the apolipoprotein E (APOE) genotype of all subjects.…”

Decline of fiber tract integrity over the adult age range: A diffusion spectrum imaging study

“…DTI studies suggest that it may be an early indicator for Alzheimer's disease related neurodegeneration in elderly subjects (15,16). In addition to aging, the ApoE4 genotype is an important modulator of brain structure in cognitively unimpaired subjects (17,18) and adds to the risk for sporadic Alzheimer's disease (19).…”

The European DTI Study on Dementia — A multicenter DTI and MRI study on Alzheimer's disease and Mild Cognitive Impairment

“…As of March 2016, it encompasses data from 13 scanners. EDSD data has already been used in numerous studies, assessing research questions such as the multicentric variability of DTI parameters derived from heterogeneous acquisition schemes, the diagnostic and prognostic potential of specific DTI parameters, as well as the utility of post-acquisition processing approaches that may improve these parameters by reducing multicentric variability (Brueggen et al, 2015;Dyrba et al, 2015;Dyrba et al, 2014;Dyrba et al, 2012;Dyrba et al, 2013;Fischer et al, 2012;Kljajevic et al, 2014;Teipel et al, 2014a;Teipel et al, 2014b;Teipel et al, 2011;Teipel et al, 2012). In the future, the data set will be continuously expanded through ongoing support from the existing partner centers as well as the steady inclusion of new centers.…”