Theaflavin-3,3′-digallate ameliorates learning and memory impairments in mice with premature brain aging induced by D-galactose

Cao, Yichou; Zhang, Yunyi; Jia, Zehan; Jia, Huining; Sun, Yi; Yuan, Hongxia; Bian, Yongle; Xu, Bingjie; Fu, Jing; Qin, Fenju

doi:10.1016/j.physbeh.2023.114077

Cited by 6 publications

(4 citation statements)

References 53 publications

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“…[103][104][105][106] A study demonstrated that theaflavin-3,3 '-digallate (TFDG) in this group of compounds showed stronger biological activity. TFDG not only ameliorated learning and memory dysfunction, 107 but also effectively diminished high-fat diet-induced liver injury and inflammatory response by inhibiting the NLRP3/IL-1β pathway through upregulation of miR-223, which reduced the excessive activation of the NLRP3 inflammasome as well as the release of large amounts of cytokines, such as IL-1βand IL-18, and alleviated high-fat diet-induced liver injury. 108 Zhao et al examined that polydatin inhibited ROS-driven TXNIP activation of the NLRP3 inflammasome by upregulating miR-200a, decrease pyroptosis, and improving fructose-induced liver inflammation and lipid deposition.…”

Section: Traditional Chinese Medicine and Its Active Ingredients Infl...mentioning

confidence: 98%

NcRNA Regulated Pyroptosis in Liver Diseases and Traditional Chinese Medicine Intervention: A Narrative Review

Deng,

Qin,

Qin

et al. 2024

JIR

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Pyroptosis is a novel pro-inflammatory mode of programmed cell death that differs from ferroptosis, necrosis, and apoptosis in terms of its onset and regulatory mechanisms. Pyroptosis is dependent on cysteine aspartate protein hydrolase (caspase)-mediated activation of GSDMD, NLRP3, and the release of pro-inflammatory cytokines, interleukin-1 (IL-1β), and interleukin-18 (IL-18), ultimately leading to cell death. Non-coding RNA (ncRNA) is a type of RNA that does not encode proteins in gene transcription but plays an important regulatory role in other post-transcriptional links. NcRNA mediates pyroptosis by regulating various related pyroptosis factors, which we termed the pyroptosis signaling pathway. Previous researches have manifested that pyroptosis is closely related to the development of liver diseases, and is essential for liver injury, alcoholic fatty liver disease (ALD), non-alcoholic fatty liver disease (NAFLD), liver fibrosis, and liver cancer. In this review, we attempt to address the role of the ncRNA-mediated pyroptosis pathway in the above liver diseases and their pathogenesis in recent years, and briefly outline that TCM (Traditional Chinese Medicine) intervene in liver diseases by modulating ncRNA-mediated pyroptosis, which will provide a strategy to find new therapeutic targets for the prevention and treatment of liver diseases in the future.

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Section: Traditional Chinese Medicine and Its Active Ingredients Infl...mentioning

confidence: 98%

NcRNA Regulated Pyroptosis in Liver Diseases and Traditional Chinese Medicine Intervention: A Narrative Review

Deng,

Qin,

Qin

et al. 2024

JIR

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“…Cao et al [ 231 ] reported that theaflavin-3,3′-digallate treatment (15, 30, and 60 mg/kg bw) improved learning and memory in the NOR and Y-maze tests, increased the brain/body mass ratio, decreased glutamate concentration and AChE activity and increased ACh concentration in the brain, and enhanced ChAT, glutaminase, and glutamine synthetase activity. It has also been reported that theaflavin-3,3′-digallate treatment of d -galactose-induced AD mice increased activity of the antioxidant enzymes GPx and SOD, while the concentration of MDA was reduced; the antioxidant genes Nrf2, Prx2, GSH-px1, and SOD1 were subsequently upregulated in the brain.…”

Section: Dietary Small Molecules and Neuroprotection – A Overview Of ...mentioning

confidence: 99%

Development of dietary small molecules as multi-targeting treatment strategies for Alzheimer's disease

Balakrishnan,

Jannat,

Choi

2024

Redox Biology

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“…Moreover, research findings indicate that impairments in the cholinergic system have the potential to impact synaptic transmission and are distinguished by synaptic loss. reduction in acetylcholine (ACh), a neurotransmitter, and an elevation in AChE activity in the brain could be caused by aging-associated cognitive dysfunction [9,10]. D-Gal is a monosaccharide that is ubiquitously present in various tissues of the human body.…”

Section: Introductionmentioning

confidence: 99%

“…At elevated concentrations, galactose oxidase catalyzes the conversion of galactose to hydrogen peroxide and aldose, leading to the generation of superoxide anion, oxygen-derived free radicals, and consequent cellular injury [11]. According to recent reports, the chronic administration of D-Gal has been related to the acceleration of aging and the influence of age-related alterations, including reduced antioxidant enzyme activities, elevated oxidant levels, and cognitive deficits [9,12,13]. Moreover, chronic administration of D-Gal also affects the cholinergic system, causing increased oxidative stress and elevated AChE activity in rodent' brains, leading to learning and memory impairment [9,[12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Purple Eggplant (Solanum melongena L.) Ameliorates D-Galactose-Induced Cognitive Impairment Through Inhibition of Oxidative Stress and Acetylcholinesterase in the Hippocampus of an Aging Rat Model

Jeefoo,

Phachonpai,

Duangjai

et al. 2023

Trends Sci

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The induction of neurotoxicity by d-galactose (D-Gal) is a widely recognized model that is utilized for investigating the process of aging and the associated cognitive impairment, as well as oxidative damage and cholinergic dysfunction. Eggplant fruit is a highly consumed vegetable owing to its high phenolic content, which exhibits antioxidant properties. The current investigation aimed to assess the effect of an aqueous extract of Thai purple eggplant (PEP) fruit (Solanum melongena L., ‘Ma Khuea Muang’) on memory impairment and explore the underlying mechanisms. The quantification of total phenolic contents was conducted on the PEP extract, and an analysis of its antioxidant activity was performed using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2-Azino-bis (3-ethyl benzothiazoline-6-sufonic acid) (ABTS) scavenging assays. Male Wistar rats were subcutaneously (s.c.) injected (150 mg/kg/day) with D-Gal to generate a model of accelerated aging and administered orally with EP extract (250, 500, and 1,000 mg/kg/day) or donepezil (DNP) (3 mg/kg/day) for 8 weeks. Cognitive performance was evaluated by the Morris water maze (MWM) and novel object recognition (NOR) tests. Malondialdehyde (MDA) level and acetylcholinesterase (AChE) and superoxide dismutase (SOD) activities in the hippocampus were also evaluated after the behavioral studies. The continuous administration of PEP extract at a dosage of 1,000 mg/kg/day or DNP resulted in the amelioration of cognitive impairment and the reversal of the increase in AChE activity caused by D-Gal in the hippocampus. Furthermore, the administration of PEP extract resulted in a significant reduction in MDA levels in the hippocampus. These findings suggest a potential attenuation of oxidative stress. The findings indicate that the PEP extract has a beneficial effect on cognitive decline induced by D-Gal, which is attributed to the restoration of cholinergic function and the reduction of oxidative damage. HIGHLIGHTS In D-galactose-induced aged rats, purple eggplant (Solanum melongena) (PEP) extract can inhibit elevated acetylcholinesterase (AChE) activity and malondialdehyde (MDA) levels in the hippocampus. The consumption of PEP extract has been found to have potential benefits in improving age-related learning and memory impairment. The utilization of PEP extract as a dietary supplement may serve as a viable option for the elderly population in the prevention of dementia. GRAPHICAL ABSTRACT

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Theaflavin-3,3′-digallate ameliorates learning and memory impairments in mice with premature brain aging induced by D-galactose

Cited by 6 publications

References 53 publications

NcRNA Regulated Pyroptosis in Liver Diseases and Traditional Chinese Medicine Intervention: A Narrative Review

NcRNA Regulated Pyroptosis in Liver Diseases and Traditional Chinese Medicine Intervention: A Narrative Review

Development of dietary small molecules as multi-targeting treatment strategies for Alzheimer's disease

Purple Eggplant (Solanum melongena L.) Ameliorates D-Galactose-Induced Cognitive Impairment Through Inhibition of Oxidative Stress and Acetylcholinesterase in the Hippocampus of an Aging Rat Model

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