Thecoma in a mare

Raoofi, Afshin; Mardjanmehr, Seyed Hossein; Mirmohammadkhani, Majid; Adib-Hashemi, Farajollah; Asadian, Peyman

doi:10.1016/j.jevs.2006.11.002

Cited by 11 publications

(10 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is possible that there may have been more mares with normal reproductive behaviour and GCTs included if histopathological examination had been performed on all cases that underwent ovariectomy during the study period; in the absence of the results of histopathological examination, horses had to demonstrate behavioural changes consistent with GCTs to be included in this study which may have therefore caused selection bias. However, these inclusion criteria were chosen to increase the specificity of case inclusion as there are many other differential diagnoses for enlarged ovaries including other ovarian tumours (teratomas (Catone et al 2004), cystadenoma and cystadenocarcinoma (Hinrichs et al 1989;Son et al 2005), dysgerminoma (Chandra et al 1998;Gehlen et al 2006;Harland et al 2009), thecoma (Raoofi et al 2006;Azizi et al 2014), lymphoma (Lock and Macy 1979;Canisso et al 2013), leiomyoma and fibroleiomyoma (Carstanjen et al 2009;Daniel et al 2015a) and adenocarcinoma (Pauwels et al 2012)), persistent anovulatory follicle, ovarian haematoma, ovarian abscess and multiple corpora lutea of pregnancy (Bosu et al 1982;Watson 1999;McCue et al 2006). It should also be recognised that not all mares with a GCT present with an enlarged ovary on rectal examination (Daniel et al 2015b); such cases would have been excluded from the current study.…”

Section: Discussionmentioning

confidence: 99%

Granulosa cell tumours in the mare: A review of 52 cases

Sherlock

Lott-Ellis

Bergren

et al. 2015

Equine Veterinary Education

View full text Add to dashboard Cite

Summary Granulosa cell tumour (GCT) is reported to be the most common ovarian neoplasm in the mare. A multicentre retrospective study evaluating the medical records of horses undergoing ovariectomy for treatment of a GCT was undertaken, documenting the presenting clinicopathological features, treatment and outcome. Follow‐up information was obtained by telephone questionnaire. Fifty‐two mares were included. Most presented with behavioural/reproductive abnormalities, including stallion‐like behaviour (50%), aggression (31%), prolonged oestrus or nymphomania (19%), and persistent anoestrus (8%). Most (93%) affected ovaries had a multilocular appearance when examined ultrasonographically. Only 60% of horses with histopathologically confirmed GCTs demonstrated elevations in serum inhibin concentrations. Twenty‐five percent of horses had histopathologically confirmed bilateral GCTs. Ninety‐four percent of horses that underwent ovariectomy were discharged from the hospital. Standing laparoscopic ovariectomies had a lower complication rate (34%) than other surgical methods. Long‐term complications were uncommon (11%). In conclusion, histopathologically confirmed GCTs can occur in the presence of normal serum inhibin concentrations. The high prevalence of bilateral GCTs indicates that thorough evaluation of the contralateral ovary is necessary. Surgical ovariectomy for treatment of GCTs has favourable short‐ and long‐term outcomes. Standing laparoscopic ovariectomy may be associated with a lower complication rate than other surgical methods.

show abstract

Section: Discussionmentioning

confidence: 99%

Granulosa cell tumours in the mare: A review of 52 cases

Sherlock

Lott-Ellis

Bergren

et al. 2015

Equine Veterinary Education

View full text Add to dashboard Cite

show abstract

“…The differential diagnoses for ovarian enlargement in the mare include neoplasia: GCT, teratoma (Catone and others 2004), serous cystadenoma (Hinrichs and others 1989), dysgerminoma (Harland and others 2009) and thecoma (Raoofi and others 2006). Non‐neoplastic differential diagnoses are persistent anovulatory follicle, haemorrhagic anovulatory follicle, ovarian haematoma, ovarian abscess, polycystic ovary and ovarian enlargement during pregnancy (Bosu and others 1982, McCue and others 1998, Watson 1999).…”

mentioning

confidence: 99%

Review of seven cases of granulosa cell tumour of the equine ovary

Crabtree¹

2011

Veterinary Record

View full text Add to dashboard Cite

This paper reviews the equine granulosa cell tumour (GCT) and describes the clinicopathological features, treatment and outcome in seven cases of GCT in mares. Mares were presented with unilateral ovarian enlargement during the 2007 to 2010 breeding seasons. The mean (sd) age of the mares was 11.7 (5.96) years. Three mares were multiparous barren, three were nulliparous and one was primigravida. Behaviour at presentation was 57 per cent anoestrus, 28 per cent with stallion-like behaviour and 14 per cent with persistent oestrus. All mares had unilateral ovarian enlargement. Six non-pregnant mares had a small and inactive contralateral ovary; the pregnant mare had a single small corpus luteum on the contralateral ovary and was at three-and-a-half months' gestation. Enlarged ovaries measured 7 cm to an estimated 30 cm in diameter. 28 per cent had a multicystic ultrasound appearance, 57 per cent were dense structures and 14 per cent were of mixed appearance. Mean concentrations of progesterone were <1 ng/ml, oestrone sulphate 3.06 (2.32) ng/ml and testosterone 0.58 (0.64) nmol/l in non-pregnant mares. Inhibin was elevated in all non-pregnant cases at 7.6 (12.45) ng/ml. The pregnant mare had concentrations of progesterone 2.5 ng/ml, oestrone sulphate 81.0 ng/ml, testosterone 1.9 nmol/l and inhibin 1.31 ng/ml. Mares demonstrating stallion-like behaviour had a significantly higher (P<0.001) testosterone concentration (1.85 [0.07] nmol/l) than those that did not (0.34 [0.26] nmol/l). Three mares underwent unilateral ovariectomy and resumed cyclic ovarian activity within nine months of surgery.

show abstract

“…Vesicular nuclei vary from ovoid to fusiform in shape, slightly eosinophilic and foamy, vacuolated cytoplasm [4], with poorly defined borders. Mitotic figures were not evident [29], in other case-mitotic amount was less than 2 cells per 10 HPF [16]. Well-circumscribed and variably sized vascular spaces filled with erythrocytes are also characteristic [10].…”

Section: Discussionmentioning

confidence: 99%

“…In human medicine, fibrothecomas represent only 1%-4.7% of ovarian tumors [18]. Clinical signs of ovarian neoplasms can be nonspecific [29]. In human medicine these tumors are asymptomatic, usually detected during routine gynecologic examination [4].…”

Section: Introductionmentioning

confidence: 99%

Ovarian Fibrothecoma in a Mare-Case Report

Tamulionytė-Skėrė,

Juodžiukynienė,

Rimkutė

et al. 2024

Preprint

View full text Add to dashboard Cite

Ovarian tumors in mares are not common in comparison to other neoplasms and are divided into three categories: gonadal stromal tumors, coelomic epithelium surface tumors, and germinative cell tumors [12]. Some ovarian neo-plasms histologically show a mixture of multiple cell types in the same tumor, such as fibrothecoma, therefore the dif-ferentiation between fibroma and thecoma is often difficult [1]. According to World Health Organization, fibrothecoma is classified as sex cords stromal tumor (pure stromal tumor) [13]. Neoplasms, such as fibrothecoma have a very scarce morphology, clinical signs, ultrasonographic view and endocrine profile. To diagnose this type of tumor, a broad clini-cal examination is needed, but histopathology remains the most accurate. Herein, we report a case of incidentally found ovarian fibrothecoma during diagnostic laparotomy in 6-year-old KWPN mare which was presented to the clinic with colic symptoms. After unilateral ovariectomy, the altered right ovary, based on histopathological features was diag-nosed as fibrothecoma.

show abstract

Thecoma in a mare

Cited by 11 publications

References 13 publications

Granulosa cell tumours in the mare: A review of 52 cases

Granulosa cell tumours in the mare: A review of 52 cases

Review of seven cases of granulosa cell tumour of the equine ovary

Ovarian Fibrothecoma in a Mare-Case Report

Contact Info

Product

Resources

About