1985
DOI: 10.1016/0042-6822(85)90327-7
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Theiler's virus RNA and protein synthesis in the central nervous system of demyelinating mice

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Cited by 62 publications
(50 citation statements)
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“…Pena Rossi et al (1997) recently provided further support for this notion by their demonstration that depletion of MΦs by mannosylated liposomes almost completely abrogates persistence of TMEV. The restricted state of BeAn virus replication in our murine MΦ cell lines resembles that reported for CNS MΦs in mice (Clatch et al, 1990 ;Cash et al, 1985). In addition, other investigators have also found that TMEV infection in murine MΦ cell lines is restricted (Obuchi et al, 1997 ;Shaw-Jackson & Michiels, 1997 ;Takata et al, 1998).…”
supporting
confidence: 59%
“…Pena Rossi et al (1997) recently provided further support for this notion by their demonstration that depletion of MΦs by mannosylated liposomes almost completely abrogates persistence of TMEV. The restricted state of BeAn virus replication in our murine MΦ cell lines resembles that reported for CNS MΦs in mice (Clatch et al, 1990 ;Cash et al, 1985). In addition, other investigators have also found that TMEV infection in murine MΦ cell lines is restricted (Obuchi et al, 1997 ;Shaw-Jackson & Michiels, 1997 ;Takata et al, 1998).…”
supporting
confidence: 59%
“…This apoptotic cell is one of several heavily labeled cells clustered together; there are two other TUNEL-negative, infected cells with fewer grains in this cluster (asterisks). Previous in situ hybridization analysis identified two populations of infected cells, low (100 to 500)-and high (Ͼ1,000)-copy-number cells, in spinal cords of mice persistently infected with DA virus (8). The infected, apoptotic cell in Fig.…”
mentioning
confidence: 99%
“…Another and perhaps more likely possibility is that oligodendrocytes are infected at the same time as other cell-types but that virus replication within oligodendrocytes is restricted as previously described for the DA strain (Cash et al, 1985(Cash et al, , 1986(Cash et al, , 1988 resulting in a slow build-up of transcripts which only become detectable with time. The same possibilities can be applied to the neurovirulent GDVII strain of TMEV which also has the ability to infect oligodendrocytes (Simas et al, 1995).…”
Section: Discussionmentioning
confidence: 91%