Theileria

Bishop, Richard P.; Odongo, David; Mann, David J.; Pearson, Terry W.; Sugimoto, Chihiro; Haines, Lee R.; Glass, Elizabeth; Jensen, Kirsty; Seitzer, Ulrike; Ahmed, Jabbar S.; Graham, Simon P.; Villiers, Etienne P. de

doi:10.1007/978-3-540-74042-1_6

Cited by 16 publications

(16 citation statements)

References 164 publications

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“…Different heat shock proteins, actin, glyceraldehyde-3-phosphate dehydrogenase, enolase and elongation factor belonged to the most readily detected proteins. This is in agreement with observations made in a preliminary analysis of the T. parva schizont proteome using a combination of high-resolution 2-D gel electrophoresis and MS (Bishop et al, 2009). …”

Section: Resultssupporting

confidence: 92%

“…Theileria parasites belong to the Apicomplexa, are transmitted by ticks and cause diseases with significant economic impact in a range of domestic livestock, including large and small ruminants (Bishop et al, 2009). Unique among eukaryotic organisms, several members of the genus Theileria possess the ability to transform the cells they infect.…”

Section: Introductionmentioning

confidence: 99%

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Proteomic analysis of the Theileria annulata schizont

Witschi

Xia

Sanderson

et al. 2013

International Journal for Parasitology

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Section: Resultssupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Proteomic analysis of the Theileria annulata schizont

Witschi

Xia

Sanderson

et al. 2013

International Journal for Parasitology

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“…For instance, T. annulata, and T. parva (the causative agents of tropical or Mediterranean and East Coast Fevers, respectively) are known to be the most pathogenic species in bovines, whereas other species, such as T. mutans , T. taurotragi, and members of the T. orientalis complex, often cause asymptomatic infections in this host group [ 11 – 13 ]. Depending on the type of theileriosis, a number of hard ticks belonging to the genera Amblyomma , Haemaphysalis , Hyalomma, and Rhipicephalus can transmit theilerioses (see Table 1 ) [ 14 ]. T. annulata causes a severe, potentially fatal disease in cattle, leading to significant economic losses in endemic countries in Africa and Asia, and is mainly transmitted by ticks of the genus Hyalomma [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…Depending on the type of theileriosis, a number of hard ticks belonging to the genera Amblyomma , Haemaphysalis , Hyalomma, and Rhipicephalus can transmit theilerioses (see Table 1 ) [ 14 ]. T. annulata causes a severe, potentially fatal disease in cattle, leading to significant economic losses in endemic countries in Africa and Asia, and is mainly transmitted by ticks of the genus Hyalomma [ 14 ]. In general, tropical theileriosis is more severe in exotic and cross-bred cattle ( Bos taurus ) than indigenous animals (e.g., Bos indicus ) [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Tick-borne diseases of bovines in Pakistan: major scope for future research and improved control

et al. 2015

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Ticks and tick-borne diseases (TBDs) affect the productivity of bovines in tropical and subtropical regions of the world, leading to a significant adverse impact on the livelihoods of resource-poor farming communities. Globally, four main TBDs, namely anaplasmosis, babesiosis, theileriosis, and cowdriosis (heartwater) affect bovines, and the former three are of major economic importance in bovines in Pakistan. Given that the livestock sector has become an integral part of Pakistan’s economy and a large number of dairy cattle are being imported into the country, in order to meet an increasing demand of milk and milk products, it is timely to review current status of bovine TBDs in Pakistan and to identify gaps in the knowledge of TBDs and their control. Although there has been a recent increase in the number of studies of TBDs in this country, information on their prevalence, distribution, tick vectors, and control is limited. This article provides a brief background on key bovine TBDs and ticks and reviews the current status of bovine TBDs in Pakistan to identify gaps in knowledge and understanding of these diseases, propose areas for future research and draw attention to the need for improved tools for the diagnosis and control of TBDs in this country.

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“…There have been a number of reviews of Theileria parva biology and genomics (Bishop et al., ; Dobbelaere & Mckeever, ; Weir et al., ) and numerous reviews relating to approaches to live vaccination and attempts to develop recombinant vaccines, most recently by Nene and Morrison (). There have also been several reviews of the infection and treatment (ITM) vaccination method, notably that by Di Giulio, Lynen, Morzaria, Oura, and Bishop () which overviews the methodology and focuses on the first large‐scale delivery of the live vaccine to pastoralists in Tanzania, and more recently by Perry () which documents the historical and institutional context of the development of the live vaccine and the current status of commercial deployment and production.…”

Section: Introductionmentioning

confidence: 99%

A review of recent research on Theileria parva : Implications for the infection and treatment vaccination method for control of East Coast fever

Bishop

Odongo

Ahmed

et al. 2020

Transbound Emerg Dis

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The infection and treatment (ITM) live vaccination method for control of Theileria parva infection in cattle is increasingly being adopted, particularly in Maasai pastoralist systems. Several studies indicate positive impacts on human livelihoods. Importantly, the first detailed protocol for live vaccine production at scale has recently been published. However, quality control and delivery issues constrain vaccination sustainability and deployment. There is evidence that the distribution of T. parva is spreading from endemic areas in East Africa, North into Southern Sudan and West into Cameroon, probably as a result of anthropogenic movement of cattle. It has also recently been demonstrated that in Kenya, T. parva derived from cape buffalo can ‘breakthrough’ the immunity induced by ITM. However, in Tanzania, breakthrough has not been reported in areas where cattle co‐graze with buffalo. It has been confirmed that buffalo in northern Uganda national parks are not infected with T. parva and R. appendiculatus appears to be absent, raising issues regarding vector distribution. Recently, there have been multiple field population genetic studies using variable number tandem repeat (VNTR) sequences and sequencing of antigen genes encoding targets of CD8+ T‐cell responses. The VNTR markers generally reveal high levels of diversity. The antigen gene sequences present within the trivalent Muguga cocktail are relatively conserved among cattle transmissible T. parva populations. By contrast, greater genetic diversity is present in antigen genes from T. parva of buffalo origin. There is also evidence from several studies for transmission of components of stocks present within the Muguga cocktail, into field ticks and cattle following induction of a carrier state by immunization. In the short term, this may increase live vaccine effectiveness, through a more homogeneous challenge, but the long‐term consequences are unknown.

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Theileria

Cited by 16 publications

References 164 publications

Proteomic analysis of the Theileria annulata schizont

Proteomic analysis of the Theileria annulata schizont

Tick-borne diseases of bovines in Pakistan: major scope for future research and improved control

A review of recent research on Theileria parva : Implications for the infection and treatment vaccination method for control of East Coast fever

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