2011
DOI: 10.4328/jcam.382
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Theophyllıne: Adverse Effects, Poisoning and Treatment Approaches

Abstract: Metilksantin türevi bir bileşik olan teofilin, tüm dünyada ucuz ve etkili olması nedeniyle astım ve kronik obstrüktif akciğer hastalığı (KOAH) tedavisinde yıllardan bu yana yaygın kullanılan bir ilaçtır. Teofilinin kan düzeyleri ile bronkodilatör etkisi arasında yakın bir ilişki vardır. Maksimum bronkodilatör etki elde etmek için kan düzeylerinin 10-20 µg/ml arasında bulunması önemlidir. Dar terapötik aralığa sahip olmasının yanı sıra birçok ilaç, diyet ve sigara, alkol gibi alışkanlıklar ile bireysel faktörle… Show more

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Cited by 2 publications
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“…Maintenance of its blood level between 10-20 µg/mL is important to obtain a maximum bronchodilator effect; its serious side effects take place over 20 µg/mL; its efficacy falls below 10 µg/mL of blood concentrations. Besides having a narrow therapeutic range, alteration of its pharmacokinetic characteristics due to individual variations, drugs, diet and habits such as smoking and alcohol has led to requirement of a simple, sensitive and reproducible assay method for determination of theophylline and its metabolites (1,2). Biological samples such as urine plasma, serum and tissue have been used in determination of theophylline for doping control investigations, clinical pharmacokinetic experiments and human liver metabolism studies (3).…”
Section: Introductionmentioning
confidence: 99%
“…Maintenance of its blood level between 10-20 µg/mL is important to obtain a maximum bronchodilator effect; its serious side effects take place over 20 µg/mL; its efficacy falls below 10 µg/mL of blood concentrations. Besides having a narrow therapeutic range, alteration of its pharmacokinetic characteristics due to individual variations, drugs, diet and habits such as smoking and alcohol has led to requirement of a simple, sensitive and reproducible assay method for determination of theophylline and its metabolites (1,2). Biological samples such as urine plasma, serum and tissue have been used in determination of theophylline for doping control investigations, clinical pharmacokinetic experiments and human liver metabolism studies (3).…”
Section: Introductionmentioning
confidence: 99%