Theophylline Inhibition of Renal and Cerebral Nucleoside Formation

Jensen, Mogens H.

doi:10.1111/j.1476-5381.1981.tb10444.x

British J Pharmacology

1981

DOI: 10.1111/j.1476-5381.1981.tb10444.x

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Theophylline Inhibition of Renal and Cerebral Nucleoside Formation

Mogens H. Jensen

Abstract: Theophylline inhibits the enzymatic formation of purine nucleosides, among these adenosine (dephosphorylated adenosine 5′‐monophosphate), in kidney and brain of the rat. Some pharmacological effects of theophylline on regional blood flow and electrophysiological activity of the nervous system may be caused by inhibition of the endogenous formation of adenosine.

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1984

1986

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Cited by 2 publications

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“…Adenosine is a physiological purine nucleoside, which has a pronounced inhibitory effect on CNS (review: Phillis & Wu 1981). Adenosine is formed by enzymatic dephosphorylation of adenosine monophosphate (AMP) by 5'-nucleotidase (EC 3.1.33, and the activity of this enzyme from rat brain can be inhibited by theophylline and other methylxanthines with AMP and other purine mononucleotides as the substrates (Tsuzuki & Newburgh 1975;Jensen 1981).…”

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confidence: 99%

Is Theophylline‐induced Seizures in Man Caused by Inhibition of Cerebral 5′‐Nucleotidase Activity?

Jensen

Jørgensen

Nielsen

et al. 1984

Acta Pharmacologica et Toxicologica

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confidence: 99%

Is Theophylline‐induced Seizures in Man Caused by Inhibition of Cerebral 5′‐Nucleotidase Activity?

Jensen

Jørgensen

Nielsen

et al. 1984

Acta Pharmacologica et Toxicologica

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Theophylline Poisoning

Gaudreault

Guay

1986

Medical Toxicology

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The recent marketing of slow release preparations of theophylline and new indications for the use of the drug have resulted in a marked increase in the sale of theophylline products. This phenomenon combined with the drug's highly variable pharmacokinetics has led to an increase in the number of theophylline intoxications. The morbidity and mortality rates associated with theophylline intoxication are significant. Therefore it is essential that clinicians are aware of the pathophysiology, clinical presentation and treatment of this poisoning. Theophylline intoxication mainly affects the gastrointestinal, cardiovascular and central nervous systems. Signs and symptoms range from mild gastrointestinal upset to serious central nervous system manifestations such as seizures, a symptom often associated with a bad prognosis. Theophylline serum concentrations are very useful for making decisions regarding treatment. However, their interpretation should take into account several factors such as the age of the patient and the type of intoxication (acute versus chronic). Prevention of gastrointestinal absorption should be the principal objective of treatment of an oral theophylline poisoning. The repetitive administration of activated charcoal not only prevents theophylline absorption but also increases its rate of Once absorbed, external methods such as haemodialysis and haemoperfusion can significantly accelerate the elimination of the drug from the body. Finally, the rapid suppression of seizures and cardiac arrhythmias are essential to prevent severe neurological sequelae and death. Since theophylline intoxication can be potentially life-threatening, its administration should be monitored with regular measurements of the serum theophylline concentration, especially in the very young and the very old.

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Theophylline Inhibition of Renal and Cerebral Nucleoside Formation

Cited by 2 publications

References 19 publications

Is Theophylline‐induced Seizures in Man Caused by Inhibition of Cerebral 5′‐Nucleotidase Activity?

Is Theophylline‐induced Seizures in Man Caused by Inhibition of Cerebral 5′‐Nucleotidase Activity?

Theophylline Poisoning

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