Theoretic-Group Criterion for Reduction of the Equation G(t, x, x',...) + e F(t, x, x',...)= 0 to the Form G(t^, x^, x^',...) = 0

Lehenkyi, V.I.

doi:10.1615/jautomatinfscien.v36.i4.30

Cited by 2 publications

(8 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Structural changes often accompany changes in the weight of reproductive organs. In our study, EP-1 treatment in Experiments 1 and 2 resulted in abnormalities in the testis and ovary structures of some individuals, which is consistent with the results of previous studies (Liu et al 2012a;Chen et al 2022;Kang et al 2022;Yu et al 2020). A previous study indicated that EP-1 treatment could result in morphological changes in the ovary, thus preventing the formation of mature follicles and normal ovulation and resulting in thinner, interstitial, and loose edema.…”

Section: Impacts Of Ep-1 Treatment On the Structure Of The Ovary And ...supporting

confidence: 93%

“…For example, EP-1 could suppress the reproduction and population growth of Phodopus campbelli (Wan et al 2006), Myodes rufocanus (Shu et al 2012), M. meridianus, P. roborovskii, and Dipus sagitta (Han et al 2013) under field conditions. However, the optimal concentration and E:P ratio of EP-1 differs across different species (Zhao et al 2007;Lv et al 2012a,b;Liu et al 2013;Massawe et al 2018;Chen et al 2020;Shi et al 2020;Chen et al 2022;Imakando et al 2022;Selemani et al 2022). In general, a dose of 10-50 ppm of EP-1 baits effectively reduced the fertility of various rodent species (Zhang 2015).…”

Section: Biodiversitymentioning

confidence: 99%

See 1 more Smart Citation

Antifertility effects of EP‐1 (quinestrol and levonorgestrel) on Pacific rats (Rattus exulans)

LIU,

TU,

LIU

et al. 2023

Integr. Zool.

View full text Add to dashboard Cite

Pest rodents pose a serious threat to island biodiversity. Fertility control could be an alternative approach to control the impact of rodents on these islands. In this study, we examined the antifertility effects of EP‐1 baits containing quinestrol (E) and levonorgestrel (P) using a dose of 50 ppm E and P at three different ratios (E:P ratio = 1:2, 1:1, and 2:1) on Pacific rats (Rattus exulans) in the Xisha Islands, Hainan, China. Compared to the control group, all animals in EP‐1 treatment groups showed significantly decreased food intake and body weight. In treated males, there were obvious abnormalities in testis structure and a significant decrease of relative seminal vesicle weight, but no significant effect on relative uterine and ovarian weights (g kg−1 body weight), or ovarian structure in females. Adding 8% sucrose to the original 50‐ppm baits (E:P ratio = 1:1) significantly increased bait palatability for males and females. This dose induced uterine edema and abnormalities of ovarian structure in females but had no significant negative effect on the relative testis, epididymis, and seminal vesicle weights (g kg−1 body weight) or sperm density in males. In summary, 50‐ppm EP‐1 (1:1) baits have the potential to disrupt the fertility of females, and 8% sucrose addition to the EP‐1 baits (E:P ratio = 1:1) could improve bait palatability. This dose disrupted the testis structure in males. Future studies are needed to improve bait acceptance and assess the antifertility effects of EP‐1 (1:1) on Pacific rats in captive breeding trials and under field conditions.

show abstract

Section: Impacts Of Ep-1 Treatment On the Structure Of The Ovary And ...supporting

confidence: 93%

Section: Biodiversitymentioning

confidence: 99%

Antifertility effects of EP‐1 (quinestrol and levonorgestrel) on Pacific rats (Rattus exulans)

LIU,

TU,

LIU

et al. 2023

Integr. Zool.

View full text Add to dashboard Cite

show abstract

“…Pilot trials are used to select the dose of a candidate contraceptive and to measure its effects on reproduction. These effects are quantified via changes in reproductive physiology, such as ovarian follicle number and type, weight, size, and histology of ovaries and testes, sperm number and quality (morphology, motility), concentration of sexual hormones, and by changes in reproductive output and litter size (Sharma et al 2014;Witmer & Raymond-Whish 2021;Chen et al 2022;Pinkham et al 2022;Selemani et al 2022).…”

Section: A Effectiveness: Is This Contraceptive Effective On the Targ...mentioning

confidence: 99%

“…The effects of contraceptives on rodents' reproduction can be more subtle than simply making animals infertile. For instance, some of these effects include reduced fertility, reflected in the production of smaller litters and/or smaller pups in field mice females mated with males dosed with EP-1 (Chen et al 2022), in laboratory rats treated with a GnRH-based oral vaccine (Pinkham et al 2022), and in Brandt's vole females mated with males treated with quinestrol (Zhao et al 2007).…”

Section: Yesmentioning

confidence: 99%

“…The best examples of the different responses of rodents to the effects of a contraceptive are found in studies on orally delivered levonorgestrel (P) and quinestrol (E), alone or in combination (EP-1). For example, both EP-1 and quinestrol affect male reproduction of striped field mice (Apodemus agrarius) (Chen et al 2022) and male and female reproduction of black rats (Selemani et al 2022). However, in Brandt's voles (Lasiopodomys brandtii), treatment with quinestrol or EP-1 resulted in no marked effects on the reproductive status of males and females although quinestrol alone significantly affected male's reproduction (Zhao et al 2007;Shi et al 2020).…”

Section: A Effectiveness: Is This Contraceptive Effective On the Targ...mentioning

confidence: 99%

See 1 more Smart Citation

Developing fertility control for rodents: a framework for researchers and practitioners

2023

View full text Add to dashboard Cite

Fertility control is often heralded as a humane and effective technique for management of overabundant wildlife, including rodents. The intention is to reduce the use of lethal and inhumane methods, increase farm productivity and food security as well as reduce disease transmission, particularly of zoonoses. We developed a framework to guide researchers and stakeholders planning to assess the effectiveness of a potential contraceptive agent for a particular species. Our guidelines describe the overarching research questions which must be sequentially addressed to ensure adequate data are collected so that a contraceptive can be registered for use in broad‐scale rodent management. The framework indicates that studies should be undertaken iteratively and, at times, in parallel, with initial research being conducted on (1) laboratory‐based captive assessments of contraceptive effects in individuals; (2) simulation of contraceptive delivery using bait markers and/or surgical sterilization of different proportions of a field‐based or enclosure population to determine how population dynamics are affected; (3) development of mathematical models which predict the outcomes of different fertility control scenarios; and (4) implementation of large‐scale, replicated trials to validate contraceptive efficacy under various management‐scale field situations. In some circumstances, fertility control may be most effective when integrated with other methods (e.g. some culling). Assessment of non‐target effects, direct and indirect, and the environmental fate of the contraceptive must also be determined. Developing fertility control for a species is a resource‐intensive commitment but will likely be less costly than the ongoing environmental and economic impacts by rodents and rodenticides in many contexts.

show abstract

Theoretic-Group Criterion for Reduction of the Equation G(t, x, x',...) + e F(t, x, x',...)= 0 to the Form G(t^, x^, x^',...) = 0

Cited by 2 publications

References 0 publications

Antifertility effects of EP‐1 (quinestrol and levonorgestrel) on Pacific rats (Rattus exulans)

Antifertility effects of EP‐1 (quinestrol and levonorgestrel) on Pacific rats (Rattus exulans)

Developing fertility control for rodents: a framework for researchers and practitioners

Contact Info

Product

Resources

About