Theoretical analysis of human muscle membrane behavior in hypokalemic periodic paralysis

Abstract-The membrane models of (Cannon et al. [l] and Alberink et al. [2] for mammaliain skeletal muscle fibers are based upon Hodgkin-Huxley descriptions of sodium, potassium delayed rectifier and leak conductance's and the capacitive current taking into account fast inactivation of sodium channels. Now inward rectifier and chloride ion currents, sodiumpotassium oump and slow inactivation of sodium channels have been inserted. The behavior of the model with respect to resting membrane potential and action potential firing does not differ remarkably from 121. The model has been used to study the removal of potassium from the T-tubular space. The inward rectifier current significantly contributes to the restoration of the normal potassium concentration after prolonged action potential firing. This may be an important mechanism to avoid muscle fatigue.

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Modeling removal of accumulated potassium from T-tubules by inward rectifier potassium channels

Wallinga

Vliek

Wienk

et al.

Proceedings of 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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Theoretical analysis of human muscle membrane behavior in hypokalemic periodic paralysis

Abstract: Computer simulations were performed to investigate the behavior of human muscle membrane with membrane defects supposed to be present in the muscular disease Hypokalemic Periodic Paralysis (HOPP). The model used for simulation was a Hodgkin-Huxley model.

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Modeling removal of accumulated potassium from T-tubules by inward rectifier potassium channels

Modeling removal of accumulated potassium from T-tubules by inward rectifier potassium channels

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