“…In addition to these studies, other theoretical calculations using semiempirical and ab initio methods have been investigated, providing evidence for concerted or stepwise processes, depending on the substitution pattern of the dipole and dipolarophile. [35][36][37][38][39][40][41][42][43][44][45] If the relative sizes of the atomic orbitals are known for the frontier orbitals of both the azomethine ylide and the dipolarophile, then a prediction of the regioselectivity in the cycloaddition reaction of an unsymmetrical dipole and dipolarophile can be made. 34 The preferred transition state will involve interaction of the larger terminal coefficients.…”
Section: Introductionmentioning
confidence: 99%
“…Intramolecular dipolar cycloaddition reactions are common with electron-poor and with electron-rich alkenes and numerous examples are provided in this review. In addition to these studies, other theoretical calculations using semiempirical and ab initio methods have been investigated, providing evidence for concerted or stepwise processes, depending on the substitution pattern of the dipole and dipolarophile. − 3 …”
“…In addition to these studies, other theoretical calculations using semiempirical and ab initio methods have been investigated, providing evidence for concerted or stepwise processes, depending on the substitution pattern of the dipole and dipolarophile. [35][36][37][38][39][40][41][42][43][44][45] If the relative sizes of the atomic orbitals are known for the frontier orbitals of both the azomethine ylide and the dipolarophile, then a prediction of the regioselectivity in the cycloaddition reaction of an unsymmetrical dipole and dipolarophile can be made. 34 The preferred transition state will involve interaction of the larger terminal coefficients.…”
Section: Introductionmentioning
confidence: 99%
“…Intramolecular dipolar cycloaddition reactions are common with electron-poor and with electron-rich alkenes and numerous examples are provided in this review. In addition to these studies, other theoretical calculations using semiempirical and ab initio methods have been investigated, providing evidence for concerted or stepwise processes, depending on the substitution pattern of the dipole and dipolarophile. − 3 …”
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