Abstract-The effect of blast-induced seismic effect on slope can be considered as a transferred and transformed process of the energy. It is necessary to know the attenuation law of blast-induced seismic wave, in order to make relatively accurate estimation for the extent of the slope affected by blasting vibration. This study applied the LS-DYNA software and adopted the Arbitrary Lagrangian-Eulerian method for numerical analysis. Simulate the surface blast of C-4 explosives in a semi-infinite space, in order to explore the slope stability with different height and gradient are computed. The result shows that the propagation law and attenuation characteristics of the detonation earthquake wave on slope are different to the condition of level ground. Comparing the horizontal displacement and vertical acceleration of the top and toe of the slope, vertical acceleration of the top particles are larger then those of toe, so there is vibration amplification effect at the top of the slope. The slope crest displacement changes slightly decrease when the slope height reaches a certain degree. The attenuation effect of blast-induced seismic wave and the amplification effect of slope exist at the same time. This study can be used as a reference in hazard control of explosion-induced vibration for the structures on the slope.