In order to design evaporators for the CO2 thermal systems effectively, it is essential to understand the fundamentals and mechanisms of flow boiling heat transfer, flow patterns and two-phase flow characteristics of CO2 inside horizontal tubes including both the macro-and micro-channels. The proper prediction models for CO2 flow boiling heat transfer should be relevant to the physical mechanisms and corresponding flow patterns. This paper presents a comprehensive review of flow boiling heat transfer and two-phase flow of CO2 characteristics and their prediction methods. First, the review addresses the extensive experimental studies on flow boiling heat transfer and two-phase flow in macro-channels and micro-channels. Then, The studies of CO2 two-phase flow patterns are summarized. Furthermore, the effects of oil on the flow boiling heat transfer and two-phase pressure drops are analyzed. The generalized mechanistic models for flow boiling heat transfer and two-phase pressure drops of CO2 and a new flow pattern map specially for CO2, which cover both macro-and micro-channels developed by Cheng et al. are presented and compared to the experimental data in the literature. It has been proved that the models and flow maps favorably agree with the experimental data. In the application aspect, comparison of simulation results and the experimental data in the real thermal systems are presented.Keywords: Carbon dioxide, flow boiling, two phase flow, flow patterns, heat transfer, flow pattern map, dryout, mechanisms, mechanistic model and applications.ICMFHT Keynote 2-2 that of R22 and NH3. As the effects of good thermophysical properties, favorably evaporation heat transfer and two-phase flow characteristics of CO2, smaller pipe dimensions can be used in its refrigeration systems. The use of CO2 in these refrigeration systems requires the understanding and prediction of convective boiling, two-phase flow patterns and pressure drops at low temperatures for achieving more accurate designs of evaporators and more energy-efficient cycles using CO2.Furthermore, CO2 has favorable thermal performance when used in air-conditioning and heat pump systems as compared to conventional refrigerants. For example, in the CO2 automobile air-conditioning system. for ambient air temperatures, the heat transfer process on the high pressure side of a CO2 cycle is not a condensation process as in conventional systems but a supercritical gas cooling process [3,4,6]. For the evaporation processes in the evaporator, CO2 evaporates at much higher pressure than conventional refrigerant R134a [1,3]. The physical and transport properties of CO2 are quite different from those of conventional refrigerants at the same saturation temperatures. The physical properties have a significant effect on the evaporation processes including the two-phase flow patterns, evaporation heat transfer characteristics and two-phase frictional pressure drops in the compact heat exchangers with micro-channels. Therefore, it is essential to understand the two-phase flow and...