Rotational autofrettage is a recently proposed method to induce beneficial residual stresses in axisymmetric hollow cylindrical bodies. The feasibility of the process has been studied for both disks and cylinders used in many engineering applications. The earlier analyses of rotational autofrettage of disks are based on certain assumptions. One of the crucial assumptions is the free rotation of the disk. However, the free rotation of the disk is practically difficult. In practice, it is feasible to rotate the disk by shrink-fitting it over a solid cylindrical mandrel. In view of this, a design of a disk-mandrel assembly for achieving rotational autofrettage in disks is proposed in this article. The main aim of the design is to obtain appropriate values of the disk-mandrel interference and the rotational speed of the assembly to prevent the loss of contact of the disk with the mandrel during rotation. The critical speeds corresponding to the yield onset, contact separation and the full plastic deformation of the disk are obtained as a function of shrink interference. The safe operating design parameters can be decided by plotting the critical speeds with varying interference values. A detailed stress analysis during elastic-plastic loading of the assembly followed by the analysis of residual stresses in the assembly after unloading is presented. The analysis is based on the plane stress assumption, Tresca yield criterion and elastic unloading. The analysis is validated with a finite element method model in ABAQUS. The proposed design is illustrated through the numerical example of an ASTM A723 disk-mandrel assembly to achieve rotational autofrettage in the disk. With a small overstrain level of 17.5% in the disk, a large magnitude of compressive residual stress, viz., 0.52 times the yield stress, is induced.