A coupled free-wake/panel method to predict the rotor downwash aerodynamic interaction and helicopter trims is presented. Free-wake method was developed to analyze aerodynamics interference of rotor wake, based on lifting-surface theory and vortex method, which relates the core radius, span station, and circulation of initial tip vortex with the blade-bound circulation distribution, and eliminates the empirical parameters during rotor free wake analysis. Helicopter fuselage with empennage was discretized into source panels. The vortex line mirror method was adopted to account for wake acceleration phenomenon that resulted from the close interaction between rotor wake and fuselage surface. The rotor wake geometry and downwash simulations were investigated including comparisons with the available measured data. Combined with the helicopter flight dynamics model and embedded in the trim procedure, the free-wake/panel coupled method was applied to calculate the rotor wake and its interference on other components of a full-scale UH-60A rotorcraft in level flight. Comparisons among predictions, referenced results, and experimental results are made for rotor wake geometries, blade-bound vortex, blade tip vortex, rotor downwash velocity, and control stick positions, and encouraging results were obtained. To validate the present method, this paper discusses the fundamental formulation, the numerical algorithms, and the simulation results.