Theoretical and Therapeutic Potential of Indoleamine Precursors in Affective Disorders

Wirz‐Justice, Anna

doi:10.1159/000117607

Cited by 20 publications

(3 citation statements)

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“…Pretscher (1968) m i Murphy et al (1970 proposed that the platelet is a suitable model to study the process occurring in monoaminergic neurons in the central nervous system. Wirz-Justice et al (1977) suggested that diurnal variations in platelets 5-HT were oppo site in phase to the central 5-HT rhythm. We {Unno et al, 1977) also observed a parallel in crease of the 5-HT level between brain and serum in rabbits administered with various doses of ¿-5-HTP.…”

Section: Discussionmentioning

confidence: 99%

L-5-HTP Treatment and Serum 5-HT Level after L-5-HTP Loading on Depressed Patients

et al. 1979

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Based on 5-HT hypothesis, L-5-HTP (150 or 300 mg/day) was given orally to 18 depressed patients. The global estimates were 2 very much improved; 8 much improved; 3 minimally improved, and 5 unchanged. The action of L-5-HTP was usually rapid. The elevation of the serum 5-HT level 1 week after L-5-HTP administration was relatively lower in the 5-HTP nonresponder group, compared with the responders. The chronological change of the serum 5-HT level in depressed patients after an oral loading dose of 3 mg/kg of L-5-HTP showed a gradual and slight elevation, compared with manic and normal groups. It seemed that the therapeutic effect of L-5-HTP on responders was related to lower 5-HT level in the brain for their pathogenesis, and that there was a metabolic disturbance of L-5-HTP into 5-HT in some depressed patients.

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Section: Discussionmentioning

confidence: 99%

L-5-HTP Treatment and Serum 5-HT Level after L-5-HTP Loading on Depressed Patients

et al. 1979

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“…Increases in the circulating levels of these pituitary hormones have been consistently reported after the administration of the serotonin precursors L-tryptophan or 5-hydroxytryptophan to normal controls (for overviews, see Wirtz-Justice 1977;Charney et al 1982). The role of serotonin on the hypothalamo-pituitary-adrenal axis is not clear.…”

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confidence: 98%

Neuroendocrine effects of l-tryptophan and dexamethasone

1986

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An infusion of L-tryptophan was administered twice to five healthy male volunteers, once after pretreatment with dexamethasone 1 mg the previous evening and once after no dexamethasone. Cortisol, prolactin, and growth hormone levels were measured, and the responses to L-tryptophan were compared with those seen after an infusion of L-threonine. L-tryptophan did not produce cortisol secretion after dexamethasone, but prolactin and growth hormone responses were noticed. The results demonstrate a stimulatory effect of L-tryptophan on prolactin and growth hormone secretion, and the former is facilitated by pretreatment with dexamethasone.

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“…Many studies agree that serotonin plays an important role in mood disorders, particularly depression (3)(4)(5)9,10,(18)(19)(20)(21)24,26,28). Today, seroto nin metabolism is well known, and it is also known that its precursor is an essential amino acid: tryptophan (23,25).…”

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confidence: 99%

Measurement of the Plasmatic Level of Free and Protein-Bound Tryptophan in Mental Pathology

P¹,

H²,

Zarifian³

et al. 1980

Neuropsychobiology

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Many authors have stressed the role of serotonin in mood disorders and some aspects of schizophrenia. Cerebral serotonin synthesis depends on the quantity of circulating free tryptophan not bound to albumin. It thus appeared interesting to estimate the two forms of tryptophan by measuring their plasmatic concentration as well as the free/total tryptophan ratio. These evaluations were performed by an automatic spectrofluorimetric method. 19 blood samples were analyzed from normal subjects and 47 from schizophrenic or manic-depressive patients including treated and untreated cases. The only significant differences in the free/total tryptophan ratio were reported in untreated paranoid schizophrenics and in anxiety cases. A dual nosological and symptomatical approach was adopted in the course of attempted correlation with biological data in order to underline the possible role of symptomatic elements common to different diagnoses. The results for melancholia agreed with those reported in the literature (4). In the case of schizophrenia, however, there are only a few reports and no discrimination has been made between untreated and treated patients or between the different types of schizophrenia. The clinical picture is different for paranoid schizophrenia which is the delusive aspect of the disease and for hebephrenic schizophrenia. It seems fairly logical to find opposite results in delusive mania and paranoid schizophrenia compared to melancholia, since delusive mania and paranoid schizophrenia have similar symptomatology which is the opposite of that found in melancholic depression.

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Theoretical and Therapeutic Potential of Indoleamine Precursors in Affective Disorders

Cited by 20 publications

References 55 publications

L-5-HTP Treatment and Serum 5-HT Level after L-5-HTP Loading on Depressed Patients

L-5-HTP Treatment and Serum 5-HT Level after L-5-HTP Loading on Depressed Patients

Neuroendocrine effects of l-tryptophan and dexamethasone

Measurement of the Plasmatic Level of Free and Protein-Bound Tryptophan in Mental Pathology

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