Theoretical Aspects of Creation of Specific Preparations for Etiotropic Therapy and Prophylaxis of West Nile Fever and Crimean Haemorrhagic Fever

Abstract

Problematic issues on creation and practical introduction of specific immune biologic preparations for therapy and prophylaxis of natural-foci arbovirus infections - West Nile fever (WNF) and Crimean hemorrhagic fever (CHF), that are not available until now, are examined. Persistent natural foci of WNF and CHF with epidemic manifestations have formed in Southern and North Caucasian Federal Districts of Russia. Markers of Wfest Nile virus are being detected in central regions of Russia and Siberia, and the presence of fraction of population immune to this infection is also detected. Analysis of literature sources that has been carried out forms a theoretical basis for creation of novel specific preparations for etiotropic therapy and prophylaxis ofWNF and CHF. Use of blood from healthy donors with sufficiently high titers of class G immunoglobulins residing in certain subjects of Russian Federation in natural foci territories with the most intensive epidemic process is possible as raw material.