Theoretical evaluation of cell membrane ion channel activation by applied magnetic fields

Pierre, T.G. St; Dobson, Jon

doi:10.1007/s002490000090

Cited by 28 publications

(12 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been estimated that the force to mechanically open an ion channel is approximately 0.2–0.4 pN 33 . Therefore, we measured the force from magnetic treatment on the cells using a method described by Kim et al Briefly, iron-loaded, ferritin-expressing cells were fixed in paraformaldehyde, added to aqueous buffer and subjected to a static magnetic field.…”

Section: Methodsmentioning

confidence: 99%

Remote regulation of glucose homeostasis in mice using genetically encoded nanoparticles

Stanley

Sauer

Kane

et al. 2014

Nat Med

208

256

View full text Add to dashboard Cite

Means for temporally regulating gene expression and cellular activity are invaluable for elucidating underlying physiological processes and would have therapeutic implications. Here we report the development of a genetically encoded system for remote regulation of gene expression by low-frequency radio waves (RFs) or a magnetic field. Iron oxide nanoparticles are synthesized intracellularly as a GFP-tagged ferritin heavy and light chain fusion. The ferritin nanoparticles associate with a camelid anti-GFP–transient receptor potential vanilloid 1 fusion protein, αGFP-TRPV1, and can transduce noninvasive RF or magnetic fields into channel activation, also showing that TRPV1 can transduce a mechanical stimulus. This, in turn, initiates calcium-dependent transgene expression. In mice with stem cell or viral expression of these genetically encoded components, remote stimulation of insulin transgene expression with RF or a magnet lowers blood glucose. This robust, repeatable method for remote regulation in vivo may ultimately have applications in basic science, technology and therapeutics.

show abstract

Section: Methodsmentioning

confidence: 99%

Remote regulation of glucose homeostasis in mice using genetically encoded nanoparticles

Stanley

Sauer

Kane

et al. 2014

Nat Med

208

256

View full text Add to dashboard Cite

show abstract

“…These effects, combined with the exceptional simplicity of tSMS hardware, confer potential for therapeutic applications in psychiatry and neurology (15,16). 1 The mechanism for the effects of static magnetic fields on neural tissue remains unknown, although various possibilities have been discussed, including deformation of ion channels due to reorientation of diamagnetic anisotropic plasma membrane phospholipids (19), coupling of mechanically-activated ion channels to ferromagnetic particles (20), and activation of voltage-gated channels by the Hall effect (21,22). Nevertheless, both theoretical considerations and experimental results indicate that the magnetic dose (i.e., the characteristics of the magnetic flux density, or B-field) has a significant impact on response (1,10).…”

Section: Introductionmentioning

confidence: 99%

Field Distribution of Transcranial Static Magnetic Stimulation in Realistic Human Head Model

Tharayil

Goetz

Bernabei

et al. 2018

Neuromodulation: Technology at the Neural Interface

View full text Add to dashboard Cite

This is the first presentation and characterization of the three-dimensional (3D) spatial distribution of the B-field generated in a human brain model by tSMS. These data can provide quantitative dosing guidance for tSMS applications across various cortical targets and subjects. The finding that the B-field gradient is high near the magnet edges should be considered in studies where neural tissue is placed close to the magnet. The observation that susceptibility has negligible effects confirms assumptions in the literature.

show abstract

“…This observation suggests that the increase in systolic BP may be a compensatory physiological response to the magnetohydrodynamic slowing of blood flow in an 8 T SMF [79]. Theoretical calculations have demonstrated that the SMF strength below 10 T cannot be a direct effect of Lorentz forces acting on the induced currents in the blood vessels [112] and calcium ions [113]. However, numerical evaluation of the fields raises safety concerns that body movements in a high SMF gradient may be able to induce electric currents in tissues which could be potentially harmful [114].…”

Section: Strong Intensity Fieldsmentioning

confidence: 90%

Effects of Static Magnetic Fields on Blood Pressure in Animals and Humans

Okano

2008

CHYR

View full text Add to dashboard Cite

It is presumed that life on Earth has evolved in the presence of natural and ubiquitous magnetic fields. It is not surprising that biological systems can respond to a wide range of static magnetic fields (SMF). It is suggested that some physiological responses seem to be mediated through the nervous system. For weak intensity SMF, the effects of geomagnetic activity on the arterial baroreflex (reflex initiated by receptors in the aortic arch that alter peripheral vasomotion) in conscious animals were investigated by measuring blood pressure and microcirculation. Baroreflex sensitivity (BRS) was assessed as an indicator of cardiac autonomic regulation on the basis of the heart rate/mean arterial blood pressure relationship during a vasodilator (sodium nitroprusside) or a vasoconstrictor (phenylephrine) treatment. This study suggests that the geomagnetic field directly modifies microcirculatory responses related to BRS. These findings may have serious implications for individuals with ischemic diseases during periods of intense geomagnetic activity or geomagnetic storms. Concerning the moderate intensity SMF effects, pharmacological procedures and experimental animals have been used to assess the sympathetic responsiveness to SMF. We have reported that continuous exposure to moderate intensity SMF for several weeks can depress or suppress the action of sympathetic agonists (norepinephrine, phenylephrine, and dobutamine) and a sympathetic antagonist (reserpine) on hemodynamics and/or blood pressure by modulating sympathetic nerve activity or BRS in animals. In contrast, in humans there is little evidence to suggest that the SMF exposure of up to 8 tesla can alter blood pressure. Thus, this review describes the SMF effects (and non-effects) on the blood pressure in animals and humans.

show abstract

Theoretical evaluation of cell membrane ion channel activation by applied magnetic fields

Cited by 28 publications

References 0 publications

Remote regulation of glucose homeostasis in mice using genetically encoded nanoparticles

Remote regulation of glucose homeostasis in mice using genetically encoded nanoparticles

Field Distribution of Transcranial Static Magnetic Stimulation in Realistic Human Head Model

Effects of Static Magnetic Fields on Blood Pressure in Animals and Humans

Contact Info

Product

Resources

About