Theoretical evaluation of the treatment effectiveness of a novel coaxial multi-slot antenna for conformal microwave ablation of tumors

Wang, Tao; Zhao, Gang; Qiu, Bensheng

doi:10.1016/j.ijheatmasstransfer.2015.06.030

Cited by 48 publications

(61 citation statements)

References 46 publications

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“…Microwave ablation systems operate in the microwave frequency ranges and the operating frequency is an important issue that differentiates the performance of different systems. It has been reported that the frequencies in the range from 900 MHz to 18 GHz are used in cancer ablation [16]. The most commonly available MWA systems work either at 915 MHz or 2.45 GHz [17], [18].…”

Section: Microwave Cancer Ablationmentioning

confidence: 99%

“…Regarding the biological tissues, the rise of the temperatures to 46 • C for a time period of 60 minutes leads to irreversible cellular damage. However, only about 5 minutes are required for the cellular damage at temperature of about 52 • C. Above 52 o C, the cells of the tumor tissue will be killed immediately [16]. If the temperature goes greater than 105 • C, tissue boiling, vaporization, and carbonization will result.…”

Section: A Theory Of Operation Of Mw Cancer Ablationmentioning

confidence: 99%

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About the Interstitial Microwave Cancer Ablation: Principles, Advantages and Challenges

et al. 2020

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This article presents a review of the interstitial microwave cancer ablation. Microwave cancer ablation is an effective technique for the cancer therapy using the electromagnetic radiations in the microwave range. The idea behind using the microwave electromagnetic radiations in cancer therapy is basically based on dielectric heating of the cancerous tissues until the death of the infected cells. This article reviews the theory of operation of the microwave cancer ablation technique with overview of the electrical properties of the biological tissues as they are key parameters to study the behavior of the cancer ablation process. Advantages of microwave cancer ablation technique over the other techniques especially its most related one, i.e., the radiofrequency cancer ablation are highlighted. Although the microwave cancer ablation has attained high attention by the researchers, many of challenges which degrade its performance still exist. The paper discusses the challenges of the microwave cancer ablation and highlights the efforts done by the researchers to tackle them. Different antenna structures utilized for microwave cancer ablation are presented with mention of their behavior, advantages and disadvantages. Moreover, some of the most recent progresses in the microwave cancer ablation field are presented.

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Section: Microwave Cancer Ablationmentioning

confidence: 99%

Section: A Theory Of Operation Of Mw Cancer Ablationmentioning

confidence: 99%

About the Interstitial Microwave Cancer Ablation: Principles, Advantages and Challenges

et al. 2020

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“…The ablative treatment family includes microwave ablation (MWA), radiofrequency ablation (RFA), ethanol ablation, laser ablation, and cryoablation [12][13][14][15][16][17]. Recently, a wide number of experimental and theoretical works have been focused on improving MWA [18][19][20][21][22][23][24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

“…Tao et al (2015) have presented a numerical evaluation of the heat transfer process in liver tumors according to temperature-dependent properties using a coaxial antenna with ten slots [25]. Their simulations showed that using a coaxial multi-slot antenna reduces over-treatment compared with a conventional coaxial antenna.…”

Section: Introductionmentioning

confidence: 99%

Numerical Analysis of Human Cancer Therapy Using Microwave Ablation

2019

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Microwave ablation is one type of hyperthermia treatment of cancer that involves heating tumor cells. This technique uses electromagnetic wave effects to kill cancer cells. A micro-coaxial antenna is introduced into the biological tissue. The radiation emitted by the antenna is absorbed by the tissue and leads to the heating of cancer cells. The diffuse increase in temperature should reach a certain value to achieve the treatment of cancer cells but it should be less than a certain other value to avoid damaging normal cells. This is why hyperthermia treatment should be carefully monitored. A numerical simulation is useful and may provide valuable information. The bio-heat equation and Maxwell’s equations are solved using the finite element method. Electro-thermal effects, temperature distribution profile, specific absorption rate (SAR), and fraction of necrotic tissue within cancer cells are analyzed. The results show that SAR and temperature distribution are strongly affected by input microwave power. High microwave power causes a high SAR value and raises the temperature above 50 °C, which may destroy healthy cells. It is revealed that with a power of 10 W, the tumor cells will be killed without damaging the surrounding tissue.

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“…The coaxial-slot antenna is very important for MWA treatment due to its low cost, simplicity, small dimensions, and high efficiency [18,19]. Ibitoy et al [20] analyzed the efficiency of different antennas proposed for MWA.…”

Section: Introductionmentioning

confidence: 99%

Use of microwave ablation for thermal treatment of solid tumors with different shapes and sizes—A computational approach

et al. 2020

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Microwave Ablation (MWA) is one of the most recent developments in the field of thermal therapy. This approach is an effective method for thermal tumor ablation by increasing the temperature above the normal physiological threshold to kill cancer cells with minimum side effects to surrounding organs due to rapid heat dispersive tissues. In the present study, the effects of the shape and size of the tumor on MWA are investigated. To obtain the temperature gradient, coupled bio-heat and electromagnetic equations are solved using a threedimensional finite element method (FEM). To extract cellular response at different temperatures and times, the three-state mathematical model was employed to achieve the ablation zone size. Results show that treatment of larger tumors is more difficult than that of smaller ones. By doubling the diameter of the tumor, the percentage of dead cancer cells is reduced by 20%. For a spherical tumor smaller than 2 cm, applying 50 W input power compared to 25 W has no significant effects on treatment efficiency and only increases the risk of damage to adjacent tissues. However, for tumors larger than 2 cm, it can increase the ablation zone up to 21%. In the spherical and oblate tumors, the mean percentage of dead cells at 6 GHz is nearly 30% higher than that at 2.45GHz, but for prolate tumors, treatment efficacy is reduced by 10% at a higher frequency. Moreover, the distance between two slots in the coaxial double slot antenna is modified based on the best treatment of prolate tumors. The findings of this study can be used to choose the optimum frequency and the best antenna design according to the shape and size of the tumor.

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Theoretical evaluation of the treatment effectiveness of a novel coaxial multi-slot antenna for conformal microwave ablation of tumors

Cited by 48 publications

References 46 publications

About the Interstitial Microwave Cancer Ablation: Principles, Advantages and Challenges

About the Interstitial Microwave Cancer Ablation: Principles, Advantages and Challenges

Numerical Analysis of Human Cancer Therapy Using Microwave Ablation

Use of microwave ablation for thermal treatment of solid tumors with different shapes and sizes—A computational approach

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