Theoretical Insight into the Phosphate-Targeted Silver’s Antibacterial Action: Differentiation between Gram (+) and Gram (−) Bacteria

Kircheva, Nikoleta; Dobrev, Stefan; Nikolova, Valya; Angelova, Silvia; Dudev, Todor

doi:10.1021/acs.inorgchem.2c01085

Cited by 9 publications

(7 citation statements)

References 65 publications

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“…The antimicrobial potential of silver cations depends on the composition and thickness of the bacterial external envelope. Gram-negative bacteria may be more susceptible to the antimicrobial effect of silver because they have thinner cellular walls than gram-positive strains [ 13 ]. This difference in bacterial structure may have reduced the GNR infection rate in the S group.…”

Section: Discussionmentioning

confidence: 99%

Silver-Mixed Port Reduces Venous Access Port Related Infection Rate Compared to Non-Silver-mixed Port: A Single-center Retrospective Analysis

Suzuki,

Michimoto,

Hasumi

et al. 2023

Cardiovasc Intervent Radiol

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Purpose Totally implantable venous access ports (TIVAPs) are increasingly used as safe and convenient central venous access devices. However, several TIVAP-related complications occur, with port/catheter infection being most common. Silver-mixed ports have recently been introduced in anticipation of reducing TIVAP infection. This study aimed to investigate the efficacy of this device in reducing port infection by examining groups with and without silver-mixed devices. Materials and Methods From April 2017 to July 2022, silver-mixed ports (S group) and non-silver-mixed port group (NS group) were reviewed at our institution. The incidence of TIVAP-related infections, patient characteristics, and bacteriological data were evaluated. Univariate and multivariate analyses were used to evaluate risk factors for TIVAP-related infection. Results A total of 607 patients (S group, n = 203; NS group, n = 404) were enrolled. The rates of TIVAP-related infection were 3.0% (n = 6) and 7.7% (n = 31) in the S and NS groups, respectively. The incidence of total infection per 1000 catheter-days were 0.114 and 0.214 the S and NS groups, respectively. In the entire group, the rates of infection were 6.1% (n = 37) and the incidence of total infection per 1000 catheter-days was 0.187. Univariate and multivariate analyses revealed a significantly lower TIVAP-related infection rate in S group than NS group (p = 0.0216, odds ratio = 2.88 confidence interval: 1.17–7.08). No gram-negative rods were detected in the S group as port infection. Conclusion Silver-mixed port may be feasible in preventing port infection. Level of evidence. Level 3, Local non-random sample.

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Section: Discussionmentioning

confidence: 99%

Silver-Mixed Port Reduces Venous Access Port Related Infection Rate Compared to Non-Silver-mixed Port: A Single-center Retrospective Analysis

Suzuki,

Michimoto,

Hasumi

et al. 2023

Cardiovasc Intervent Radiol

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“…This combination of theoretical method/basis set has been meticulously calibrated/validated in several of our previous studies with respect to available experimental data, and has proven to be dependable, as it reliably reproduced the structure of a series of representative metal constructs [ 47 ] as well as the Gibbs free energies of metal substitution in acetate, imidazole and glycine complexes [ 48 ]. The M062X/6-311++G(d,p)//SDD level of theory has been recently used in the study of the competition between Ag + and Ni 2+ in nickel enzymes, and between Ag + and the key constituents of the bacterial cell wall/membrane [ 49 , 50 ].…”

Section: Methodsmentioning

confidence: 99%

Lanthanides as Calcium Mimetic Species in Calcium-Signaling/Buffering Proteins: The Effect of Lanthanide Type on the Ca2+/Ln3+ Competition

Nikolova

Kircheva

Dobrev

et al. 2023

IJMS

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Lanthanides, the 14 4f-block elements plus Lanthanum, have been extensively used to study the structure and biochemical properties of metalloproteins. The characteristics of lanthanides within the lanthanide series are similar, but not identical. The present research offers a systematic investigation of the ability of the entire Ln3+ series to substitute for Ca2+ in biological systems. A well-calibrated DFT/PCM protocol is employed in studying the factors that control the metal selectivity in biological systems by modeling typical calcium signaling/buffering binding sites and elucidating the thermodynamic outcome of the competition between the “alien” La3+/Ln3+ and “native” Ca2+, and La3+ − Ln3+ within the lanthanide series. The calculations performed reveal that the major determinant of the Ca2+/Ln3+ selectivity in calcium proteins is the net charge of the calcium binding pocket; the more negative the charge, the higher the competitiveness of the trivalent Ln3+ with respect to its Ca2+ contender. Solvent exposure of the binding site also influences the process; buried active centers with net charge of −4 or −3 are characterized by higher Ln3+ over Ca2+ selectivity, whereas it is the opposite for sites with overall charge of −1. Within the series, the competition between La3+ and its fellow lanthanides is determined by the balance between two competing effects: electronic (favoring heavier lanthanides) and solvation (generally favoring the lighter lanthanides).

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“…Among the typical metals, the application of Ag (Figure 17e) in antibacterial wound research has a long history. Ag is cheaper than gold [126], and Ag has better germicidal efficacy than Cu at the same concentration [127]. The chemical properties of Ag are very stable, and its corrosion resistance is also strong.…”

Section: Antibacterial Composite Hydrogel Dressingsmentioning

confidence: 99%

Advances in Functional Hydrogel Wound Dressings: A Review

et al. 2023

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One of the most advanced, promising, and commercially viable research issues in the world of hydrogel dressing is gaining functionality to achieve improved therapeutic impact or even intelligent wound repair. In addition to the merits of ordinary hydrogel dressings, functional hydrogel dressings can adjust their chemical/physical properties to satisfy different wound types, carry out the corresponding reactions to actively create a healing environment conducive to wound repair, and can also control drug release to provide a long-lasting benefit. Although a lot of in-depth research has been conducted over the last few decades, very few studies have been properly summarized. In order to give researchers a basic blueprint for designing functional hydrogel dressings and to motivate them to develop ever-more intelligent wound dressings, we summarized the development of functional hydrogel dressings in recent years, as well as the current situation and future trends, in light of their preparation mechanisms and functional effects.

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Theoretical Insight into the Phosphate-Targeted Silver’s Antibacterial Action: Differentiation between Gram (+) and Gram (−) Bacteria

Cited by 9 publications

References 65 publications

Silver-Mixed Port Reduces Venous Access Port Related Infection Rate Compared to Non-Silver-mixed Port: A Single-center Retrospective Analysis

Silver-Mixed Port Reduces Venous Access Port Related Infection Rate Compared to Non-Silver-mixed Port: A Single-center Retrospective Analysis

Lanthanides as Calcium Mimetic Species in Calcium-Signaling/Buffering Proteins: The Effect of Lanthanide Type on the Ca2+/Ln3+ Competition

Advances in Functional Hydrogel Wound Dressings: A Review

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