Theoretical insights into the enantiodivergence induced by chiral phosphoric acid catalysis with a Lewis acid for the synthesis of N–N axially chiral atropisomers

Abstract

A detailed theoretical mechanistic investigation on the chiral phosphoric acid (CPA)-catalyzed Paal-Knorr reactions, with and without the presence of a Lewis acid, for the synthesis of N−N axially chiral atropisomers...