Theoretical investigation into the dissolved oxygen levels in follicular fluid of the developing human follicle using mathematical modelling

Redding, Gabe P.; Bronlund, John E.; Hart, A. L.

doi:10.1071/rd07190

Cited by 55 publications

(57 citation statements)

References 20 publications

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“…Predicted and actual measurements of oxygen concentration in antral follicles are similar to those in venous blood (Redding et al, 2008). Thus, the oxygen supply to the oocyte may only be limited at the late preantral to early antral stage and at the early preovulatory stage (Redding et al, 2007(Redding et al, , 2008. Follicle angiogenesis at these stages could be crucial for oocyte oxygen-ation and development (Van Blerkom, 2000).…”

Section: Carbohydrate Metabolism Throughout Folliculogenesismentioning

confidence: 83%

“…Other studies in the human (Redding et al, 2008) and bovine (Clark and Stokes, 2011) predict a sharp rise in intrafollicular oxygen with antrum formation, peaking at the end of the early antral stage before decreasing through the antral to preovulatory stages, and to finally increase around the time of ovulation. Predicted and actual measurements of oxygen concentration in antral follicles are similar to those in venous blood (Redding et al, 2008). Thus, the oxygen supply to the oocyte may only be limited at the late preantral to early antral stage and at the early preovulatory stage (Redding et al, 2007(Redding et al, , 2008.…”

Section: Carbohydrate Metabolism Throughout Folliculogenesismentioning

confidence: 87%

“…Mathematical modeling was used to study the mean oxygen concentration in human follicles; and predicted a low oxygen concentration within large preantral follicles, yet sufficient to reach the oocyte (Redding et al, 2007). Other studies in the human (Redding et al, 2008) and bovine (Clark and Stokes, 2011) predict a sharp rise in intrafollicular oxygen with antrum formation, peaking at the end of the early antral stage before decreasing through the antral to preovulatory stages, and to finally increase around the time of ovulation. Predicted and actual measurements of oxygen concentration in antral follicles are similar to those in venous blood (Redding et al, 2008).…”

Section: Carbohydrate Metabolism Throughout Folliculogenesismentioning

confidence: 99%

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Metabolism throughout follicle and oocyte development in mammals

Collado-Fernandez¹,

Picton²,

Dumollard³

2012

Int. J. Dev. Biol.

148

102

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Metabolic studies of mammalian embryos started with the development of in vitro culture systems more than 40 years ago. More recently, metabolic studies have begun to shed light on the requirements of growing oocytes/follicles from the earliest stages of folliculogenesis. While growing oocytes preferentially metabolise pyruvate over glucose, the somatic compartment of ovarian follicles is more glycolytic. The metabolic preferences of the oocyte are reflected in the early zygote, which becomes increasingly dependent on glycolytic energy production as development progresses to the blastocyst stage. Furthermore, the intricate metabolic relationship between each oocyte and its somatic surroundings is critical for oocyte growth and developmental competence. Measurements of amino acid turnover in bovine oocytes indicate that glutamine, arginine and leucine are consistently depleted, while alanine is produced, showing similarities with amino acid turnover in preimplantation embryos. Amino acid profiling is a good predictor of embryo quality and might also turn out to be a predictor of oocyte developmental competence. Finally, recent studies have uncovered lipid metabolism in oocytes and early embryos, suggesting that endogenous fatty acids might be used for energy production. Together, metabolic studies have revealed the multiplicity of energetic substrates used by oocytes and early embryos, and suggest that the versatility of the metabolic pathways available for energy production is key for high developmental potential. Metabolic studies of early embryos are now being applied to follicle culture, and the goal of describing the metabolome of the growing oocyte in its follicle is now very attainable.

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Section: Carbohydrate Metabolism Throughout Folliculogenesismentioning

confidence: 83%

Section: Carbohydrate Metabolism Throughout Folliculogenesismentioning

confidence: 87%

Section: Carbohydrate Metabolism Throughout Folliculogenesismentioning

confidence: 99%

See 1 more Smart Citation

Metabolism throughout follicle and oocyte development in mammals

Collado-Fernandez¹,

Picton²,

Dumollard³

2012

Int. J. Dev. Biol.

148

102

View full text Add to dashboard Cite

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“…indeed. may even be the stimulus for antral formation (Redding et al 2007(Redding et al , 2008. However, previously we have reported that HIF activity is not associated with follicular growth at any stage of mouse ovarian folliculogenesis, but is evident immediately following the ovulatory signal, associated with granulosa cell luteinisation (Tam et al 2010).…”

Section: Discussionmentioning

confidence: 96%

Microarray analysis of mRNA from cumulus cells following in vivo or in vitro maturation of mouse cumulus–oocyte complexes

Kind

Banwell

Gebhardt

et al. 2013

Reprod. Fertil. Dev.

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The IVM of mammalian cumulus–oocyte complexes (COCs) yields reduced oocyte developmental competence compared with oocytes matured in vivo. Altered cumulus cell function during IVM is implicated as one cause for this difference. We have conducted a microarray analysis of cumulus cell mRNA following IVM or in vivo maturation (IVV). Mouse COCs were sourced from ovaries of 21-day-old CBAB6F1 mice 46 h after equine chorionic gonadotrophin (5 IU, i.p.) or from oviducts following treatment with 5 IU eCG (61 h) and 5 IU human chorionic gonadotrophin (13 h). IVM was performed in α-Minimal Essential Medium with 50 mIU FSH for 17 h. Three independent RNA samples were assessed using the Affymetrix Gene Chip Mouse Genome 430 2.0 array (Affymetrix, Santa Clara, CA, USA). In total, 1593 genes were differentially expressed, with 811 genes upregulated and 782 genes downregulated in IVM compared with IVV cumulus cells; selected genes were validated by real-time reverse transcription–polymerase chain reaction (RT-PCR). Surprisingly, haemoglobin α (Hba-a1) was highly expressed in IVV relative to IVM cumulus cells, which was verified by both RT-PCR and western blot analysis. Because haemoglobin regulates O2 and/or nitric oxide availability, we postulate that it may contribute to regulation of these gases during the ovulatory period in vivo. These data will provide a useful resource to determine differences in cumulus cell function that are possibly linked to oocyte competence.

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“…The oxygen concentrations in the follicular fluid (FF) are lower in large follicles than in small follicles in cows (de Castro et al 2008), sows (Basini et al 2004) and women (Redding et al 2008). The oxygen concentration in the FF decreases with the oocyte maturation (Fischer et al 1992).…”

Section: Roles Of Hypoxic Signaling In Follicular Development and Ovumentioning

confidence: 99%

Multiple roles of hypoxia in ovarian function: roles of hypoxia-inducible factor-related and -unrelated signals during the luteal phase

Nishimura

Okuda

2016

Reprod. Fertil. Dev.

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Promotion of Science (JSPS). 2 Abstract.There is increasing interest in the role of oxygen conditions in the microenvironment of organs, since the discovery of a hypoxia-specific transcription factor, hypoxia-inducible factor-1 (HIF1). Ovarian function has several phases that change day by day, including ovulation, follicular growth, corpus luteum formation and regression. These phases are regulated by many factors, such as pituitary hormones and local hormones including steroids, peptides and cytokines, as well as oxygen conditions. Hypoxia strongly induces angiogenesis because transcription of a potent angiogenic factor, vascular endothelial growth factor, is regulated by HIF1. Follicular development and luteal formation are accompanied by a drastic increase of angiogenesis assisted by the HIF1-VEGF signaling. Hypoxia is also one of the factors for inducing luteolysis by suppressing progesterone synthesis and by promoting apoptosis of luteal cells. This review focuses on recent studies for hypoxic conditions as well as HIF1-regulated genes and proteins in the regulation of ovarian function. Additional keywords Hypoxia, hypoxia-inducible factor IntroductionOvarian function has several phases that change day by day, including follicular growth, ovulation, luteal formation and regression. Follicles progress to ovulation through the proliferation of granulosa and theca cells. After ovulation, the corpus luteum (CL) develops accompanied by active angiogenesis, and when conception does not occur, regresses with the 3 decrease of progesterone (P4) synthesis and apoptosis of luteal cells. During the ovarian cycle, blood flow to the ovary changes, and affects the regulation of ovarian cycles Niswender et al. 1976;Ford and Chenault 1981;Wise et al. 1982;Magness et al. 1983;Acosta et al. 2002). Changes in ovarian blood flow result in the changes in the transport of nutrients, hormones and gases, including O2 to the ovary. In cows, ovarian blood flow has been reported to decrease during luteal regression, and to be kept at low levels during luteal formation after ovulation (Wise et al. 1982). Since a dominant follicle progress to ovulation during luteal regression (McCracken et al. 1999), follicular growth before ovulation occurs in parallel with the decrease of blood flow to the ovary. Furthermore, the oxygen content in ovarian venous blood begins to decrease at the late luteal stage (Wise et al. 1982). These findings indicate that the low oxygen condition (hypoxia) caused by the decreased blood supply is a characteristic part of the ovarian environment during follicular growth, ovulation and luteal formation. as VEGF (Forsythe et al. 1996; Kimura et al. 2001), endothelial nitric oxide synthase (eNOS) (Coulet et al. 2003), and heme oxygenase-1 (HOX-1) (Lee et al. 1997). VEGF stimulates angiogenesis and increases the permeability of blood vessels (Ferrara et al. 2003). eNOS and HOX-1 generate NO and carbon monoxide, which are potent vasodilatory substances that augment perfusion of the hypoxic tissue. At the cellular leve...

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Theoretical investigation into the dissolved oxygen levels in follicular fluid of the developing human follicle using mathematical modelling

Cited by 55 publications

References 20 publications

Metabolism throughout follicle and oocyte development in mammals

Metabolism throughout follicle and oocyte development in mammals

Microarray analysis of mRNA from cumulus cells following in vivo or in vitro maturation of mouse cumulus–oocyte complexes

Multiple roles of hypoxia in ovarian function: roles of hypoxia-inducible factor-related and -unrelated signals during the luteal phase

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