Theoretical mechanism of temporary renal function improvement after abdominal aortic aneurysm surgery

Hoshina, Katsuyuki; Akai, Takafumi; Ohshima, Marie; Watanabe, Toshiaki; Yamamoto, Sota

doi:10.1097/md.0000000000007428

Cited by 1 publication

(2 citation statements)

References 14 publications

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“…Blood circulation can be simulated by an electric circuit because both are flow systems with different substances and scales and expected to obey the Ohm's law and, hence, circuit theory [13]. Many studies performed so far had adopted electronic simulation methodology in the study of the cardiovascular system, and most of them were quantitative analyses using numerical modeling [13,17,18]. In contrast, our current study was a qualitative one, focused only on the causal relationship between CA stenosis and PDA aneurysm and not on the actual numerical values.…”

Section: Discussionmentioning

confidence: 99%

“…If a potentiometer is added in series to a fixed resistor, the combined resistance cannot be less than the latter. On the other hand, an aneurysm, whether saccular or fusiform, indicates an increase in the vascular diameter and a decrease in the flow resistance [17,18]. The occurrence of turbulent flow in an aneurysm can act as a resistance to the flow.…”

Section: Discussionmentioning

confidence: 99%

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Causal Relationship between Celiac Stenosis and Pancreaticoduodenal Artery Aneurysm: Interpretation by Simulation Using an Electric Circuit

Yoon

Choi

Shin

et al. 2020

BioMed Research International

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Pancreaticoduodenal artery (PDA) aneurysm and celiac artery (CA) stenosis are rare diseases in themselves. Interestingly, however, there are more cases documented in the literature in which these two disease entities occurred together than could be coincidental, and CA stenosis has been suggested as the provocative condition in developing PDA aneurysm. This study is aimed at examining the causal relationship between CA stenosis and PDA aneurysm by simulating the splanchnic circulation with an electric circuit. A patient with multiple PDA aneurysms and collaterals with CA stenosis was treated in our institution using hybrid techniques. The patient’s pre- and postoperative status was simulated using an electric circuit, and the two possible scenarios were tested for compatibility: the stenosis-first scenario vs. the aneurysm-first scenario. The simulation was performed in two ways: using Simulink® software (MATLAB® Release 2018b) and actual circuit construction on a breadboard. The stenosis-first scenario showed that as the CA stenosis progresses, the blood flow through PDA increases, favoring the development of an aneurysm and/or collaterals if the artery was already compromised by a weakening condition. On the other hand, the aneurysm-first scenario also showed that if the aneurysm or collaterals developed first, the aneurysm will steal the blood flow through the CA, causing it to collapse if the artery was already compromised by increased wall tension. Contrary to the common belief, this study showed that in patients suffering from concurrent CA stenosis and PDA aneurysm, either condition could develop first and predispose the development of the other. The simulation of splanchnic blood flow with an electric circuit provides a useful tool for analyzing rare vascular diseases that are difficult to provoke in clinical and animal studies.

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