Theoretical modeling of tunable vibrations of three-dimensional serpentine structures for simultaneous measurement of adherent cell mass and modulus

Zhao, J. Z.; Li, Weican; Guo, Xingming; Wang, Heling; Li, Jinghua

doi:10.1557/mrs.2020.253

Cited by 3 publications

(5 citation statements)

References 61 publications

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“…In addition, Cook et al, 30 and Ehret et al, 31 argued that the IMBSM suggests that knowledge does affect adherence, along with behavioural skills (including self-efficacy) and treatment motivation. Zhao et al, 32 also reported that older patients with multimorbidities adhere less to their chronic medications because of insufficient knowledge, negative attitude and lack of confidence.…”

Section: Conceptual Framework: Information-motivational Behavioural Skills Modelmentioning

confidence: 99%

Application of the information-motivation-behavioural skills model to strengthen eye care follow-up amongst glaucoma patients

Tshivhase

Khoza

Tshitangano

2021

African Vision and Eye Health

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Background: Many factors influence glaucoma medication adherence. A better understanding of the relationships between knowledge, attitude and patients’ practice problems in using glaucoma medications may reveal opportunities for intervention that could improve patients’ clinical outcomes. The challenge of non-adherence to glaucoma follow-up and treatment plans remains a significant global healthcare concern. Non-adherence to medication is a challenge to effective treatment of many chronic diseases, including glaucoma and remains so even with the implementation of strategies aimed at improving adherence. In South Africa, the information-motivation and behavioural skills model (IMBSM) of glaucoma adherence constructs might be useful in describing and predicting adherence behaviours that have not been articulated to people with glaucoma.Aim: The study applied the IMBSM in strengthening eye care follow-up amongst glaucoma patients in the Limpopo province of South Africa.Setting: The study was conducted at a selected hospital in the Vhembe District, Limpopo province, South Africa.Methods: A cross-sectional quantitative descriptive study via questionnaire was conducted on patients who were taking intraocular pressure-lowering medications and subject to follow up at a glaucoma clinic. A total of 429 eligible patients were purposefully selected for data collection using structured questionnaires. Oral informed consent was obtained from all respondents before they completed the questionnaires.Results: Only 55% of the total sample reported a glaucoma non-adherence rate of less than or equal to 95% compared with 45% who reported glaucoma adherence rate of more than or equal to 95%. Independent predictors of non-adherence were: inadequate glaucoma knowledge (29%), forgetfulness (26%) and patients’ beliefs (18%).Conclusion: The findings revealed the need for on-going glaucoma educational and informational interventions to address the motivation and adherence behavioural skills of patients to strengthen the current levels of glaucoma adherence behaviour. These findings suggest that the application of the IMBSM might improve glaucoma patients’ adherence.

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Section: Conceptual Framework: Information-motivational Behavioural Skills Modelmentioning

confidence: 99%

Application of the information-motivation-behavioural skills model to strengthen eye care follow-up amongst glaucoma patients

Tshivhase

Khoza

Tshitangano

2021

African Vision and Eye Health

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Section: Skin Stimulation Using Bioelectronics With Dynamic Actuatorsmentioning

confidence: 99%

Section: Characterization Of Biological Tissues Mechanical Propertiesmentioning

confidence: 99%

“…To characterize the cells' mechanical properties without damaging it, vibration‐based method that exploits tunable 3D architectures, formed by deterministic assembly, can be used to quantify the cells' mass and Young's modulus independently based on resonant frequencies. Zhao et al 95 tailored the design of a 3D microstructure to undergo vibration tests and deform in the linear elastic range to simultaneously determine the mass (2–14 ng) and modulus (2–20 kPa) of living cells, such as osteoblast and fibroblasts, from the resonant frequencies of the microstructure. Figure 3C‐i shows a representative structure with a cell (e.g., organoid) where the contour indicates the normalized vibration amplitude.…”

Section: Characterization Of Biological Tissues Mechanical Propertiesmentioning

confidence: 99%

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Flexible electronics with dynamic interfaces for biomedical monitoring, stimulation, and characterization

Guo

Avila

Xie

2021

Int Journal of Mech Sys Dyn

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Recent developments in the fields of materials science and engineering technology (mechanical, electrical, biomedical) lay the foundation to design flexible bioelectronics with dynamic interfaces, widely used in biomedical/clinical monitoring, stimulation, and characterization. Examples of this technology include body motion and physiological signal monitoring through soft wearable devices, mechanical characterization of biological tissues, skin stimulation using dynamic actuators, and energy harvesting in biomedical implants. Typically, these bioelectronic systems feature thin form factors for enhanced flexibility and soft elastomeric encapsulations that provide skin-compliant mechanics for seamless integration with biological tissues. This review examines the rapid and continuous progress of bioelectronics in the context of design strategies including materials, mechanics, and structure to achieve high performance dynamic interfaces in biomedicine. It concludes with a concise summary and insights into the ongoing opportunities and challenges facing developments of bioelectronics with dynamic interfaces for future applications.

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“…This paper reports a significant milestone that now allows researchers to overcome computationally costly methods that cannot meet the demand for real-time solutions for manufacturing and clinical applications. An article by Zhao et al 5 discusses vibration-based methods that can be used to effectively characterize the physical properties of biological materials, with an increasing focus on the mechanics of individual, living cells. Frankel 6 makes a case for visual components of materials research to help clarify the researchers' thinking and engage the public.…”

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confidence: 99%

Reaching the horizon: FirstMRS Bulletin Impactarticles published

Buehler¹,

Rao²

2020

MRS Bull.

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Theoretical modeling of tunable vibrations of three-dimensional serpentine structures for simultaneous measurement of adherent cell mass and modulus

Abstract: Abstract

Cited by 3 publications

References 61 publications

Application of the information-motivation-behavioural skills model to strengthen eye care follow-up amongst glaucoma patients

Application of the information-motivation-behavioural skills model to strengthen eye care follow-up amongst glaucoma patients

Flexible electronics with dynamic interfaces for biomedical monitoring, stimulation, and characterization

Reaching the horizon: FirstMRS Bulletin Impactarticles published

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