Theoretical Research on Excited States: Ultraviolet and Fluorescence Spectra of Aromatic Amino Acids

Liu, Yonggang; Xu, Jianjie; Han, Li; Liu, Qiangqiang; Yang, Yunfan; Li, Zeren; Lu, Zhongyuan; Zhang, Hang; Guo, Tengxiao; Li, Qiao

doi:10.1007/s12539-020-00395-3

Cited by 10 publications

(4 citation statements)

References 28 publications

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“…Furthermore, the presence of TRP in the nanomaterial was shown by UV-visible spectroscopy at 277 nm wavelength [46], which is evidence of the binding of amino acids to the nanomaterial. The yield of the first method is 38% which is slightly lower than the yield of the second method by 3%.…”

Section: Resultsmentioning

confidence: 94%

Synthesis of smart carriers based on tryptophan-functionalized magnetic nanoparticles and its application in 5-fluorouracil delivery

et al. 2022

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Multifunctional nanocarriers, specifically for tumor targeting and traceable features, have been increasingly considered in cancer therapies. Herein, a novel targeting agent (TA), tryptophan (TRP), was proposed for the synthesis of functionalized (3-aminopropyl) triethoxysilane-iron oxide nanoparticles using two methods, creating a smart drug delivery system (DDS). In one method, two-step, glutaraldehyde (GA) as a linker, bonded TRP and amino-functionalized magnetite, and in the second method, one step, TRP binding was carried out by (3-dimethyl aminopropyl)-N’-ethyl carbodiimide hydrochloride (EDC)/N-hydroxysuccinimide ester. The synthesis yield of the second method was 7% higher than the first method. After synthesizing DDS, 5-fluorouracil (5-FU) was loaded on nanocarriers and was observed TRP functionalized nanoparticles by GA have better loading efficiency, which was 50% greater than the product from the one-step method. A pH-sensitive release profile was also studied for 5-FU/DDS with the release of almost 75% and 50% at pH 5.5 and 7.4, respectively. To analyze the biological aspects of nanocarriers, human breast cancer, MCF-7, and embryonic kidney, HEK293, cell lines were used for cellular uptake and 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assays. In vitro studies confirmed that TRP can act as a TA as its cellular uptake through cancerous cells was 40% greater than normal cells, and the MTT assay confirmed that using DDS can increase and decrease the cell viability of normal cells and cancerous cells, respectively, compared to free drug. Therefore, it was concluded that advanced nano-assembly is a great candidate for breast cancer cell-targeted delivery.

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Section: Resultsmentioning

confidence: 94%

Synthesis of smart carriers based on tryptophan-functionalized magnetic nanoparticles and its application in 5-fluorouracil delivery

et al. 2022

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“…The NAC calculations for all the molecules were performed with the B3LYP functional and the TZVP basis set as implemented in ORCA 5.0.3 software . The effective Huang–Rhys factor (S), associated vibrational frequency (ω eff ), and reorganization energy per mode were obtained from the ORCA excited-state dynamics (ESD) module by adding the Hessian matrix of minimum energy point structure of S 1 and S 0 . , …”

Section: Theoretical Methodology and Computational Detailsmentioning

confidence: 99%

Exploring Thioxanthone Derivatives as Singlet Oxygen Photosensitizers for Photodynamic Therapy at the Near-IR Region

Sivasakthi,

Samanta

2023

J. Phys. Chem. A

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In the lowest excited triplet state, the excited photosensitizer reacts with tissue oxygen and forms reactive oxygen species (ROS), which kills tissue cells in photodynamic therapy (PDT). Metal-free thio-based pure organic molecules and analogous nucleobases can be used as photosensitizers for PDT applications. Using quantum chemical methods, we studied one- and two-photon optical absorptions, fluorescence, and other excited-state properties of substituted thioxanthone derivatives for their potential as photosensitizers for PDT. Our calculated values were compared with the available experimental data. The calculation of the intersystem crossing rate constant for these photosensitizers explains the high quantum yield of the formation of ROS, as reported experimentally. The excited triplet-state population of the photosensitizer occurs through the 1π–π* → 3n−π* channel of intersystem crossing and increases in the presence of halogen substitution.

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“…12 Nevertheless, they cannot be directly measured due to the overlap of their spectra. 13 Besides, Phe has the lowest fluorescence quantum yield. 14 Hence, an attempt was made in this paper to collect the gas sample fluorescence data in the storeroom using 3D fluorescence detection technology during cucumber storage.…”

Section: Introductionmentioning

confidence: 99%

“…12 Nevertheless, they cannot be directly measured due to the overlap of their spectra. 13 Besides, Phe has the lowest fluorescence quantum yield. 14…”

Section: Introductionmentioning

confidence: 99%

A microbial quantity monitoring model based on 3D fluorescence data of the cucumber storeroom gas and its use in providing auxiliary early spoilage warning

Yuan

Liu

Yin

et al. 2022

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Theoretical Research on Excited States: Ultraviolet and Fluorescence Spectra of Aromatic Amino Acids

Cited by 10 publications

References 28 publications

Synthesis of smart carriers based on tryptophan-functionalized magnetic nanoparticles and its application in 5-fluorouracil delivery

Synthesis of smart carriers based on tryptophan-functionalized magnetic nanoparticles and its application in 5-fluorouracil delivery

Exploring Thioxanthone Derivatives as Singlet Oxygen Photosensitizers for Photodynamic Therapy at the Near-IR Region

A microbial quantity monitoring model based on 3D fluorescence data of the cucumber storeroom gas and its use in providing auxiliary early spoilage warning

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