Theoretical, single crystal and molecular docking analysis of tetrazolo[1,5-a]pyrimidine-6-carboxylate derivatives

Haleel, Azees Khan; Rafi, Ummer Muhammed; Jayathuna, Mugamathu Ali; Rahiman, A. Kalilur

doi:10.1016/j.molstruc.2021.131706

Journal of Molecular Structure

2022

DOI: 10.1016/j.molstruc.2021.131706

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Theoretical, single crystal and molecular docking analysis of tetrazolo[1,5-a]pyrimidine-6-carboxylate derivatives

Azees Khan Haleel

Ummer Muhammed Rafi

Mugamathu Ali Jayathuna

et al.

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Recent Progress on the Synthesis, Biological Activity of Fused Pyrimidines from Azole Amines

Zhuang,

Wang,

Liu

et al. 2024

Eur J Org Chem

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Fused pyrimidines are a class of heterocyclic compounds that have gained considerable interest due to their extensive biological activities and potential applications in drug development. This review article aims to provide a comprehensive overview of the latest synthetic approaches to fused pyrimidines, including Michael reactions, multicomponent reactions, metal‐catalyzed reactions, photocatalytic reactions, peroxide‐mediated reactions, and inverse electron demand Diels–Alder reactions. Furthermore, the biological activities of these compounds, such as their ability to combat cancer and microbial infections, are also discussed. This review article summarizes the existing literature on the synthesis and biological activity of fused pyrimidines from 2020 to 2023. We hope this review article will inspire the development of more effective and less toxic fused pyrimidine drugs with well‐designed structures.

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Recent Progress on the Synthesis, Biological Activity of Fused Pyrimidines from Azole Amines

Zhuang,

Wang,

Liu

et al. 2024

Eur J Org Chem

View full text Add to dashboard Cite

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The crystal structure of ethyl 7-ethyl-5-methyl-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate, C₁₀H₁₅N₅O₂

Wang

Mou

Sun

2022

Zeitschrift Für Kristallographie - New Crystal Structures

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C10H15N5O2, triclinic, P 1 ‾ $P\overline{1}$ (no. 2), a = 8.0501(16) Å, b = 8.6163(17) Å, c = 9.6654(19) Å, α = 69.74(3)°, β = 75.79(3)°, γ = 87.43(3)°, V = 609.1(2) Å3, Z = 2, R gt (F) = 0.0593, wR ref (F 2) = 0.1821, T = 293 K.

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Theoretical, single crystal and molecular docking analysis of tetrazolo[1,5-a]pyrimidine-6-carboxylate derivatives

Cited by 2 publications

References 43 publications

Recent Progress on the Synthesis, Biological Activity of Fused Pyrimidines from Azole Amines

Recent Progress on the Synthesis, Biological Activity of Fused Pyrimidines from Azole Amines

The crystal structure of ethyl 7-ethyl-5-methyl-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate, C₁₀H₁₅N₅O₂

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Theoretical, single crystal and molecular docking analysis of tetrazolo[1,5-a]pyrimidine-6-carboxylate derivatives

Cited by 2 publications

References 43 publications

Recent Progress on the Synthesis, Biological Activity of Fused Pyrimidines from Azole Amines

Recent Progress on the Synthesis, Biological Activity of Fused Pyrimidines from Azole Amines

The crystal structure of ethyl 7-ethyl-5-methyl-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate, C10H15N5O2

Contact Info

Product

Resources

About

The crystal structure of ethyl 7-ethyl-5-methyl-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate, C₁₀H₁₅N₅O₂