Theoretical studies on complexes of calcium ion with amino acids

Qin, Peng-Hua; Lu, Wen‐Cai; Qin, Wei; Zhang, Wei; Xie, Hailiang

doi:10.1007/s40242-014-3303-z

Cited by 7 publications

(2 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been shown that amino acids can chelate Ca 2 þ by composing a divalent metal-amino acid complexes [114]. The bidentate salt-bridge structure is the most favorable for all the twenty kinds of amino acids to chelate Ca 2 þ to both the oxygen atoms of the negatively carboxylate group in the backbone [115]. These results demonstrated that Ala, Cit and Pro could protect erythrocytes against apoptosis through quenching • OH, inhibiting the generation of ROS or release of cytochrome c or chelating Ca 2 þ with subsequent preventing influx of Ca 2 þ and activation of calpain, caspase-8, caspase-9 and caspase-3.…”

Section: Effects Of Ala Cit and Pro On • Oh-induced Apoptosismentioning

confidence: 99%

The metabolites of glutamine prevent hydroxyl radical-induced apoptosis through inhibiting mitochondria and calcium ion involved pathways in fish erythrocytes

Jiang

Liu

et al. 2016

Free Radical Biology and Medicine

View full text Add to dashboard Cite

a b s t r a c tThe present study explored the apoptosis pathways in hydroxyl radicals ( • OH)-induced carp erythrocytes. Carp erythrocytes were treated with the caspase inhibitors in physiological carp saline (PCS) or Ca 2 þ -free PCS in the presence of 40 μM FeSO 4 /20 μM H 2 O 2 . The results showed that the generation of reactive oxygen species (ROS), the release of cytochrome c and DNA fragmentation were caspase-dependent, and Ca 2 þ was involved in calpain activation and phosphatidylserine (PS) exposure in • OH-induced carp erythrocytes. Moreover, the results suggested that caspases were involved in PS exposure, and Ca 2 þ was involved in DNA fragmentation in • OH-induced fish erythrocytes. These results demonstrated that there might be two apoptosis pathways in fish erythrocytes, one is the caspase and cytochrome c-dependent apoptosis that is similar to that in mammal nucleated cells, the other is the Ca 2 þ -involved apoptosis that was similar to that in mammal non-nucleated erythrocytes. So, fish erythrocytes may be used as a model for studying oxidative stress and apoptosis in mammal cells. Furthermore, the present study investigated the effects of glutamine (Gln)'s metabolites [alanine (Ala), citrulline (Cit), proline (Pro) and their combination (Ala 10 Pro 4 Cit 1 )] on the pathways of apoptosis in fish erythrocytes. The results displayed that Ala, Cit, Pro and Ala 10 Pro 4 Cit 1 effectively suppressed ROS generation, cytochrome c release, activation of caspase-3, caspase-8 and caspase-9 at the physiological concentrations, prevented Ca 2 þ influx, calpain activation, PS exposure, DNA fragmentation and the degradation of the cytoskeleton and oxidation of membrane and hemoglobin (Hb) and increased activity of anti-hydroxyl radical (AHR) in • OH-induced carp erythrocytes. Ala 10 Pro 4 Cit 1 produced a synergistic effect of inhibited oxidative stress and apoptosis in fish erythrocytes. These results demonstrated that Ala, Cit, Pro and their combination can protect mammal erythrocytes and nucleated cells against oxidative stress and apoptosis. The studies supported the use of Gln, Ala, Cit and Pro as oxidative stress and apoptosis inhibitors in mammal cells and the hypothesis that the inhibited effects of Gln on oxidative stress and apoptosis are at least partly dependent on that of its metabolites in mammalian.

show abstract

Section: Effects Of Ala Cit and Pro On • Oh-induced Apoptosismentioning

confidence: 99%

The metabolites of glutamine prevent hydroxyl radical-induced apoptosis through inhibiting mitochondria and calcium ion involved pathways in fish erythrocytes

Jiang

Liu

et al. 2016

Free Radical Biology and Medicine

View full text Add to dashboard Cite

show abstract

“…The connection between the Ca and N in the amino group of glycine is strengthened by their close proximity because of its comparatively smaller size. 49 Hence, the Ca-glycine complexes exhibit greater stability as compared to the Ca complexes including other AAs. A significant oxidation peak at 0.83 V results from the glycine in the NaOH solution oxidizing to formaldehyde during the positive potential sweep, which is facilitated by the Ca-glycine binding.…”

Section: Detection Of Glycine In a Real Samplementioning

confidence: 99%

Ca@Cu-CD nanoprobe for dual detection of glycine and ex vivo glycine imaging

Behera,

Mishra,

Mishra

et al. 2024

J. Mater. Chem. B

View full text Add to dashboard Cite

show abstract

How to Experimentally Determine the Influence of the Weak Nuclear Force in Promoting Molecular Chirality via Heavy–Metal Promoted Autocatalytic Synthesis of Amino Acids

Cowan

2024

ChemistrySelect

View full text Add to dashboard Cite

The potential impact of the parity non‐conserving (PNC) weak nuclear interaction on the chirality of a nascent chiral carbon center has previously been examined in the context of evolutionary models for enantiomeric selectivity in the formation of natural amino acids and nucleic acids. Since the PNC effect is the only inherently handed property in nature, it is an obvious candidate to consider in those cases where there is a natural selectivity for a specific enantiomer, including the molecular building blocks of the molecules of life. Over geological timeframes, the potential impact of the PNC weak nuclear force on chiral preference appears feasible. Key requirements included an autocatalytic reaction cycle and involvement of metal‐ion catalysts. While prior studies offer no feasible path to experimentally test the hypothesis; the Z5‐dependence of the PNC interaction does suggest that catalysis by heavy elements could yield observable chiral preferences within an experimentally accessible timeframe. Calculations of the magnitude of the effect are presented for select heavy‐elements and it is shown that chiral preference could be observed within a time span of weeks to months when such metals are used to promote amino acid synthesis via an autocatalytic Strecker reaction.

show abstract

Theoretical studies on complexes of calcium ion with amino acids

Cited by 7 publications

References 24 publications

The metabolites of glutamine prevent hydroxyl radical-induced apoptosis through inhibiting mitochondria and calcium ion involved pathways in fish erythrocytes

The metabolites of glutamine prevent hydroxyl radical-induced apoptosis through inhibiting mitochondria and calcium ion involved pathways in fish erythrocytes

Ca@Cu-CD nanoprobe for dual detection of glycine and ex vivo glycine imaging

How to Experimentally Determine the Influence of the Weak Nuclear Force in Promoting Molecular Chirality via Heavy–Metal Promoted Autocatalytic Synthesis of Amino Acids

Contact Info

Product

Resources

About