Theoretical Study of Dual-Direction Dipolar Excitation of Ions in Linear Ion Traps

Dang, Qiankun; Xu, Fuxing; Wang, Liang; Huang, Xiaohua; Dai, Xinhua; Fang, Xiang; Wang, Rizhi; Ding, Chuan‐Fan

doi:10.1007/s13361-015-1317-5

Cited by 3 publications

(3 citation statements)

References 42 publications

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“…As mentioned previously, ions can be resonantly excited by a single frequency ac wave. A variant which increases CID efficiency is dual direction excitation [142] (Figure 6b), in which ions are excited in both x and y in a linear ion trap by applying a single dipolar ac to each pair of electrodes. Because ions are excited simultaneously in both directions, the kinetic energy of the ions increases, thereby…”

Section: Activationmentioning

confidence: 99%

Resonance methods in quadrupole ion traps

Snyder

Peng

Cooks

2017

Chemical Physics Letters

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The quadrupole ion trap is widely used in the chemical physics community for making measurements on dynamical systems, both intramolecular (e.g. ion fragmentation reactions) and intermolecular (e.g. ion/molecule reactions). In this review, we discuss linear and nonlinear resonances in quadrupole ion traps, an understanding of which is critical for operation of these devices and interpretation of the data which they provide. The effect of quadrupole field nonlinearity is addressed, with important implications for promoting fragmentation and achieving unique methods of mass scanning. Methods that depend on ion resonances (i.e. matching an external perturbation with an ion's induced frequency of motion) are discussed, including ion isolation, ion activation, and ion ejection.

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Section: Activationmentioning

confidence: 99%

Resonance methods in quadrupole ion traps

Snyder

Peng

Cooks

2017

Chemical Physics Letters

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“…Subsequently, they collide with background gas molecules, converting the kinetic energy into chemical bonding energy and leading to the dissociation of the ions into fragment ions . To improve the efficiency of CID and obtain more fragmentation information, various techniques have been developed, such as pulsed q dissociation (PQD), pulsed q dynamic CID, dual-direction excitation, − and changing the duty cycle of the AC signal …”

Section: Introductionmentioning

confidence: 99%

“…Previous studies have explored the use of dual-direction excitation in ion traps. Cooks et al achieved triple-stage spectra by simultaneously applying different dipole excitation signals to two pairs of electrical stages in a sinusoidal-waveform-driven ion trap mass spectrometer. − Ding et al performed simulations to investigate the ion motion in response to dual-direction dipolar excitation in linear ion trap and used dual-direction dipolar excitation to enhance ion excitation and CID efficiency . Xu et al reduced space charge effect using rhombic ion excitation and ejection in a linear ion trap and improved performances of the Brick mass spectrometer using a quadrupole enhanced dipolar resonance ejection by connections of quadrupolar excitation signal and dipolar excitation signal …”

Section: Introductionmentioning

confidence: 99%

Direct Performance of Triple-Stage Tandem Mass Spectrometry Analysis Using Dual-Direction Dipolar Excitation in a Digital Linear Ion Trap

Duan,

Zhang,

Xian

et al. 2024

J. Am. Soc. Mass Spectrom.

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The ion trap mass spectrometer offers a unique advantage over other mass spectrometers by enabling multistage tandem mass spectrometry analysis with a single mass analyzer. It is employed to generate fragment ions through collision-induced dissociation (CID) usually by applying alternating current (AC) signals to a pair of electrodes for dipole excitation. The process of achieving double-stage tandem mass spectrometry analysis (MS/ MS) in the mass spectrometer involves successive stages of injection, cooling, isolation, excitation, and scanning. For triplestage tandem mass spectrometry analysis (MS/MS/MS), additional stages of isolation, cooling, and excitation need to be added based on the MS/MS analysis, resulting in a complex and time-consuming mass spectrometry workflow. In this study, a digital ion trap technology with the method of simultaneously applying dipole excitation signals to two pairs of electrodes in the ion trap was developed. This allows fragmentation of the precursor ion in one direction while exciting the first-generation product ions in the other direction, enabling direct acquisition of MS/MS/MS spectra. This approach simplifies the process of tandem mass spectrometry, as demonstrated by experimental studies on methamphetamine, which show that dual-direction excitation effectively reduces workflow and enhances the intensity of product ions. Additionally, the method of direct MS/MS/MS spectra achieved through dual-direction excitation in a digital ion trap mass spectrometer allows for a lower q value of the precursor ion owing to a pseudopotential well depth that is 1.648 times greater than that of a traditional sinusoidal ion trap. The experiments of analyzing high concentration n-butyl acetate and isobutyl acetate have shown that the implementation of MS/MS/MS analysis using dualdirection excitation can provide more mass spectral information and effectively distinguish between the two isomeric samples. The results of direct triple-stage spectra obtained by this technique for several typical volatile hazardous chemicals demonstrate the method's capability for rapid analysis and detection of such substances. In summary, the developed method of dual-directional excitation coupled with digital ion trap technology enables direct performance of triple-stage tandem mass spectrometry analysis, improving fragment ion intensities and providing more valuable mass spectral information. It offers advantages such as simplified workflows, faster analysis, and enhanced accuracy for analyzing compounds with low mass fragment ions.

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Stimulated Motion Suppression (STMS): a New Approach to Break the Resolution Barrier for Ion Trap Mass Spectrometry

Zhou

Chiang

et al. 2018

J. Am. Soc. Mass Spectrom.

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Ion trap is an excellent platform to perform tandem mass spectrometry (MS/MS), but has an intrinsic drawback in resolving power. Using ion resonant ejection as an example, the resolution degradation can be largely attributed to the broadening of the resonant frequency band (RFB) between ion motion and driving alternative-current (AC). To solve this problem, stimulated motion suppression (STMS) was developed. The key idea of STMS is the use of two suppression alternative-current (SAC) signals, which both have reversed initial phases to the main AC. The SACs can block the unexpected sideband ion resonances (or ejections), therefore playing a key role in sharpening the RFB. The proof-of-concept has been demonstrated through ion trajectory simulations and validated experimentally. STMS provides a new and versatile means for the improvement of the ion trap resolution, which for a long time has reached the bottleneck through conventional methods, e.g., increasing the radio-frequency (RF) voltage and decreasing the mass scan rate. At the end, it is worth noting that the idea of STMS is very general and principally can be applied in any RF device for the purposes of high-resolution mass analysis and ion isolation. Graphical Abstract ᅟ.

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Theoretical Study of Dual-Direction Dipolar Excitation of Ions in Linear Ion Traps

Cited by 3 publications

References 42 publications

Resonance methods in quadrupole ion traps

Resonance methods in quadrupole ion traps

Direct Performance of Triple-Stage Tandem Mass Spectrometry Analysis Using Dual-Direction Dipolar Excitation in a Digital Linear Ion Trap

Stimulated Motion Suppression (STMS): a New Approach to Break the Resolution Barrier for Ion Trap Mass Spectrometry

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