Theoretical Study of Inspiratory Flow Waveforms during Mechanical Ventilation on Pulmonary Blood Flow and Gas Exchange

Niranjan, S.; Bidani, A.; Ghorbel, Fathi H.; Zwischenberger, Joseph B.; Clark, Julie

doi:10.1006/cbmr.1999.1515

Cited by 7 publications

(5 citation statements)

References 39 publications

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“…The same result of (33) could also be obtained by inserting (31) into (19). Considering (30), (31) and (32) at the beginning of inspiration time (t i = 0), the following expressions result:…”

Section: Inspiration Timementioning

confidence: 55%

“…Among the different systems proposed for removing this limitation [8,9,[17][18][19][20][21][22][23][24][25][26][27][28] and thus for evaluating the effect of varying inspiratory airflow waveforms on clinical parameters of mechanically ventilated patients [29][30][31], the Advanced Lung Ventilation System (ALVS) has been conceived and designed for the waveform optimization of airways pressure excitation when controlled breathings have to be apply during assisted/ controlled ventilation to anaesthetized or severe brain injured patients, the respiratory mechanics of which can be assumed steady and linear [9,[32][33][34][35][36]. The functional flexibility and versatility of ALVS are both extremely useful for the research activity with an optimal and advanced ventilator as well as for its laboratory and clinical development and testing [9].…”

Section: Introductionmentioning

confidence: 99%

“…steady condition, i.e. the end of transient inspiration time (t TI = 5 INS ),(20),(30),(31),(32) and(33) provide for the following expressions:…”

mentioning

confidence: 99%

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Theoretical modeling of airways pressure waveform for dual-controlled ventilation with physiological pattern and linear respiratory mechanics

Montecchia

2011

JBiSE

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The present paper describes the theoretical treatment performed for the geometrical optimization of advanced and improved-shape waveforms as airways pressure excitation for controlled breathings in dual-controlled ventilation applied to anaesthetized or severe brain injured patients, the respiratory mechanics of which can be assumed linear. Advanced means insensitive to patient breathing activity as well as to ventilator settings while improved-shape intends in comparison to conventional square waveform for a progressive approaching towards physiological transpulmonary pressure and respiratory airflow waveforms. Such functional features along with the best ventilation control for the specific therapeutic requirements of each patient can be achieved through the implementation of both diagnostic and compensation procedures effectively carried out by the Advance Lung Ventilation System (ALVS) already successfully tested for square waveform as airways pressure excitation. Triangular and trapezoidal waveforms have been considered as airways pressure excitation. The results shows that the latter fits completely the requirements for a physiological pattern of endoalveolar pressure and respiratory airflow waveforms, while the former exhibits a lower physiological behaviour but it is anyhow periodically recommended for performing adequately the powerful diagnostic procedure

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Section: Inspiration Timementioning

confidence: 55%

Section: Introductionmentioning

confidence: 99%

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Theoretical modeling of airways pressure waveform for dual-controlled ventilation with physiological pattern and linear respiratory mechanics

Montecchia

2011

JBiSE

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“…The respiratory system during mechanical ventilation is modeled as a lumped system composed of a compliant lung (with compliance C lung ), an airway (with resistance R aw representing the tube and the bronchial tree) and an additional compliant vessel representing the chest wall (simplified from 20 ). Nonlinear flow-dependent resistance to airflow in the upper airways was ignored.…”

Section: Respiratory Systemmentioning

confidence: 99%

“…When adaptable to the individual patient, the model could form the basis of a decision support system by predicting the effect of any considered volume infusion in specific patients. [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] A first, and to our knowledge only step towards the identification of factors that influence the arterial pressure variations by cardiovascular modeling was made by Messerges. 14 He endorsed the assumption that mathematical modeling potentially lead to more clinically relevant interpretation of dynamic indices, and introduced positive pressure ventilation, venous compression and a rightward septum shift into an existing cardiovascular model.…”

Section: Introductionmentioning

confidence: 99%

A Mathematical Model for the Prediction of Fluid Responsiveness

Lansdorp

Putten

Keijzer

et al. 2013

Cardiovasc Eng Tech

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Your article is protected by copyright and all rights are held exclusively by Biomedical Engineering Society. This e-offprint is for personal use only and shall not be selfarchived in electronic repositories. If you wish to self-archive your work, please use the accepted author's version for posting to your own website or your institution's repository. You may further deposit the accepted author's version on a funder's repository at a funder's request, provided it is not made publicly available until 12 months after publication.

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Pulmonary Medicine, Applications of Biomedical Engineering to

Cherniack

Longobardo

2006

Wiley Encyclopedia of Biomedical Engineering

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Pulmonary medicine is concerned with preventing and treating diseases that affect the lungs as well as the entire respiratory system, i.e., the muscles that create the pressures needed to bring air into and out of the lungs, as well as the sensors and the respiratory neurons that set the level and pattern of breathing. The respiratory system provides oxygen for body metabolic needs and rapidly removes in the form of carbon dioxide the acids produced as a result of metabolic processes. It is functionally and structurally linked to other systems such as the cardiovascular and renal system, which also act to maintain tissue oxygenation and acid–base balance. The lung is the primary interface of the respiratory system with the outside world, and because breathing involves the daily exchange of almost 7500 L of air containing microorganisms and injurious particles, the lung is the part of the respiratory system most commonly affected by disease. However, disease can affect any part of the respiratory system. Unchecked, some respiratory diseases lead to respiratory failure characterized by hypoxia and elevated levels of carbon dioxide. In addition, intermittent hypoxia and hypercapnia can occur during sleep as a consequence of episodic upper airway obstruction. Bioengineering applies the basic scientific approaches of biology, physics, chemistry, and engineering to the medicine of the respiratory system to develop mathematical models, which describe and explain pathophysiological processes and develop instruments and diagnostic processes to treat or support the respiratory system.

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Theoretical Study of Inspiratory Flow Waveforms during Mechanical Ventilation on Pulmonary Blood Flow and Gas Exchange

Cited by 7 publications

References 39 publications

Theoretical modeling of airways pressure waveform for dual-controlled ventilation with physiological pattern and linear respiratory mechanics

Theoretical modeling of airways pressure waveform for dual-controlled ventilation with physiological pattern and linear respiratory mechanics

A Mathematical Model for the Prediction of Fluid Responsiveness

Pulmonary Medicine, Applications of Biomedical Engineering to

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