Theory and Experiment for the Effect of Vascular Microstructure on Surface Tissue Heat Transfer—Part II: Model Formulation and Solution

Jiji, Latif M.; Weinbaum, Sheldon; Lemons, Daniel E.

doi:10.1115/1.3138502

Cited by 113 publications

(34 citation statements)

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“…This layer is not highly vascular, but is transversed by vessels branching and proceeding from deeper tissue to the capillary vasculature in the dermis [147]. These transverse vessels are believed to be thermally insignificant [148] and the thermal effect of blood perfusion is therefore usually neglected in the subcutaneous fat [147].…”

Section: Mathematical Model and Numerical Methods 21 Anatomic And Phmentioning

confidence: 99%

Numerical Prediction of the Intracellular ICE Formation Zone during Cryosurgery on a Nodular Basal Cell Carcinoma Using Liquid Nitrogen Spray

Sun

Martı́nez-Suástegui

Wang

et al. 2012

International Journal of Spray and Combustion Dynamics

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Cryosurgery is a surgical technique that employs freezing to destroy target tumor tissue. While the main objective during a cryosurgical procedure is to ensure tissue destruction within the cryolesion, the greatest challenge is how to spare the surrounding healthy tissues from cryoablation. In this work, a historical review of the field of cryosurgery is presented followed by a theoretical study where a mathematical model is developed for cryosurgery on a basal cell carcinoma (BCC) using liquid nitrogen (LN 2 ) spray. The model takes into consideration the anatomic structure of skin tissue and the irregular geometry of BCC. In particular, a methodology for quantitatively determining the extent of the intracellular ice formation (IIF) zone based on the tissue temperature and cooling rate (CR) is proposed, which can directly relate to the necrosis of the cancer cells after cryosurgery. The model is then used to analyze formation of the IIF zone during cryosurgery on a BCC and quantification is provided for the volume of the final IIF zone. A parametric study is also carried out to investigate the effect of various protocol parameters on the final IIF zone. The results should be useful for dermatologists for pre-treatment surgery planning.

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Section: Mathematical Model and Numerical Methods 21 Anatomic And Phmentioning

confidence: 99%

Numerical Prediction of the Intracellular ICE Formation Zone during Cryosurgery on a Nodular Basal Cell Carcinoma Using Liquid Nitrogen Spray

Sun

Martı́nez-Suástegui

Wang

et al. 2012

International Journal of Spray and Combustion Dynamics

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“…Among the most complete of all bioheat models is that of Weinbaum et al 16,31,32 They utilized a multilayer model of skin and skin-adjacent tissue which was based on the anatomy of a rabbit animal model. As with the work of Chen and Holmes, the complexity of the Weinbaum-Jiji model and its anatomical genesis have greatly limited its use for practical problems, such as for the female uterus.…”

Section: Heat Transfer Within the Tissuementioning

confidence: 99%

A Simulation of Gas-Based, Endometrial-Ablation Therapy

Sparrow

Abraham

2007

Ann Biomed Eng

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The method of numerical simulation has been employed to evaluate the use of a gas as a heating medium for endometrial ablation for the treatment of menorrhagia and uterine fibroids. The simulations encompassed fluid flow and heat transfer within the gaseous medium which serves to heat the uterine lining and the coupled heat conduction in the uterine tissue. For the case study featured here, helium at a temperature of 140 degrees C was employed as the heating medium. A total therapy duration of 6 min was modeled. The outcome of the simulation has provided quantitative information about the detailed necrosis depths that can be attained by the application of the therapy. In particular, necrosis depths on the order of 5 mm were achieved. It was also shown that by making use of a tailored pattern of fluid flow within the uterine cavity, particular zones on the uterine lining such as fibroids can be selectively targeted. Furthermore, the duration of the therapy needed to achieve a desired degree of necrosis can be predicted in advance. The advantages of a gas-based therapy relative to a liquid-based therapy are identified. Significant among these is the capability of the gas-based therapy to target specific zones which require treatment, while sparing healthy tissue. Another significant advantage of gas-based therapy is that it enables the use of higher temperatures which, in turn, allows the therapeutic process to be performed in a shorter time duration.

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“…developed by Jiji et al (1984) and extended by Song et al (1987. ) The W-J equation can be used only if equilibration length is smaller than the actual vessel length (Baish 1986, Qi 1990.)…”

Section: Weinbaum-jiji (W-j) Model a Three Layer Model For Peripheramentioning

confidence: 99%

A Small Artery Heat Transfer Model for Self-Heated Thermistor Measurements of Perfusion in the Kidney Cortex

Anderson

Valvano

1994

Journal of Biomechanical Engineering

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Theory and Experiment for the Effect of Vascular Microstructure on Surface Tissue Heat Transfer—Part II: Model Formulation and Solution

Cited by 113 publications

References 0 publications

Numerical Prediction of the Intracellular ICE Formation Zone during Cryosurgery on a Nodular Basal Cell Carcinoma Using Liquid Nitrogen Spray

Numerical Prediction of the Intracellular ICE Formation Zone during Cryosurgery on a Nodular Basal Cell Carcinoma Using Liquid Nitrogen Spray

A Simulation of Gas-Based, Endometrial-Ablation Therapy

A Small Artery Heat Transfer Model for Self-Heated Thermistor Measurements of Perfusion in the Kidney Cortex

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