Theory and Practice of Mixing: A Review

Barabash, V. M.; Абиев, Р. Ш.; Кулов, Н. Н.

doi:10.1134/s004057951804036x

Cited by 30 publications

(16 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mixing is crucial to many process scale-up projects. [1][2][3][4] It affects a diverse range of chemically-intensive processes such as phase-transfer catalysis, [5][6][7][8] additive manufacturing, [9][10][11] fuel combustion, 12 flow chemistry, 13 powder formulation, 14,15 biotechnology, 16 and (most pertinent to this paper) myriad reaction scale-ups in tank reactors. [16][17][18][19][20] Mixing represents one of the most effective, non-chemical means of process improvement.…”

Section: Impact Of Mixingmentioning

confidence: 99%

Computer Vision for Kinetic Analysis of Lab- and Process-scale Mixing Phenomena

Barrington,

Dickinson,

McGuire

et al. 2022

Preprint

View full text Add to dashboard Cite

A software platform for the computer vision-enabled analysis of mixing phenomena of relevance to process scale-up is described. By bringing new and known time-resolved mixing metrics under one platform, hitherto unavailable comparisons of pixel-derived mixing metrics are exemplified across non-chemical and chemical processes. The analytical methods described are applicable using any camera and across an appreciable range of reactor scales, from development through to process scale-up. A case study in nucleophilic aromatic substitution run on 5L-scale shows how camera and offline concentration measurements can be correlated. In some cases, it can be shown that camera data holds the power to predict reaction progress.

show abstract

Section: Impact Of Mixingmentioning

confidence: 99%

Computer Vision for Kinetic Analysis of Lab- and Process-scale Mixing Phenomena

Barrington,

Dickinson,

McGuire

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…The basic principle of magnetic mixing was first described by the patents of Hershler in 1965 [4,5]. Since then, various reports have been published on the application of a magnetic mixing reactor and many reactor designs have been developed mostly for biocatalytic processes [6]. In a flow-through magnetic fluidized bed reactor system (MFBRS), superparamagnetic nanoparticles covered by immobilized lipase as a biocatalyst were agitated by alternating magnetic field generated by electromagnets of variable strengths and frequencies [7].…”

Section: Bioreactor Designs Using Agitated Magnetic Particlesmentioning

confidence: 99%

Magnetically Agitated Nanoparticle-Based Batch Reactors for Biocatalysis with Immobilized Aspartate Ammonia-Lyase

et al. 2021

View full text Add to dashboard Cite

In this study, we investigated the influence of different modes of magnetic mixing on effective enzyme activity of aspartate ammonia-lyase from Pseudomonas fluorescens immobilized onto epoxy-functionalized magnetic nanoparticles by covalent binding (AAL-MNP). The effective specific enzyme activity of AAL-MNPs in traditional shake vial method was compared to the specific activity of the MNP-based biocatalyst in two devices designed for magnetic agitation. The first device agitated the AAL-MNPs by moving two permanent magnets at two opposite sides of a vial in x-axis direction (being perpendicular to the y-axis of the vial); the second device unsettled the MNP biocatalyst by rotating the two permanent magnets around the y-axis of the vial. In a traditional shake vial, the substrate and biocatalyst move in the same direction with the same pattern. In magnetic agitation modes, the MNPs responded differently to the external magnetic field of two permanent magnets. In the axial agitation mode, MNPs formed a moving cloud inside the vial, whereas in the rotating agitation mode, they formed a ring. Especially, the rotating agitation of the MNPs generated small fluid flow inside the vial enabling the mixing of the reaction mixture, leading to enhanced effective activity of AAL-MNPs compared to shake vial agitation.

show abstract

“…[6] Magnetic stirrers belong to the second type of mixers, where the process occurs by the action of hydrodynamic forces that are controlled by the flow shear rate, the cluster cross-sectional area, and the dynamic viscosity of the fluid. [7] When the samples are too concentrated and present high solid fractions and high viscosities, planetary mixing (kneading) is used instead. [8] The selected mixing procedure is connected with the structure and the properties of the casted slurry and subsequently with its performance once the cell is prepared.…”

Section: Introductionmentioning

confidence: 99%

Relevance of the Catholyte Mixing Method for Solid‐State Composite Cathodes

et al. 2021

View full text Add to dashboard Cite

The significant impact of the process steps on the electrode performance is one of the least developed aspects in the field of solid‐state batteries despite being a key issue for the transference of lab‐scale developments to production scale. To demonstrate that the knowledge of production parameters is essential, a set of high active material loading solid‐state batteries with a lithium metal anode and a polymer electrolyte is fabricated using different mixing methods for the catholyte preparation. Depending on the shear rate of the mixer, the polymer molecular weight and consequently, the viscosity of the catholyte is affected and these differences are preserved during the slurry preparation and electrode coating. The electrochemical performance of each cathode is studied in full‐cell configuration obtaining high areal capacities (≈1 mAh cm−2) and high specific capacities (92%, 82%, and 95% of the theoretical capacity of LiFePO4). After 50 cycles, composite cathodes mixed with high‐shear‐rate techniques experience a capacity fade related with the larger degree of deagglomeration of the C65 occurring when less viscous catholytes are used. Low‐shear‐rate cathodes keep the starting capacity, revealing a protective role of the catholyte during the wet‐mixing process.

show abstract

Theory and Practice of Mixing: A Review

Cited by 30 publications

References 27 publications

Computer Vision for Kinetic Analysis of Lab- and Process-scale Mixing Phenomena

Computer Vision for Kinetic Analysis of Lab- and Process-scale Mixing Phenomena

Magnetically Agitated Nanoparticle-Based Batch Reactors for Biocatalysis with Immobilized Aspartate Ammonia-Lyase

Relevance of the Catholyte Mixing Method for Solid‐State Composite Cathodes

Contact Info

Product

Resources

About