Theory, Measurement, and Application of Thermal Properties of Biomaterials

Bowman, H. F.; Cravalho, E.G.; Woods, Mark

doi:10.1146/annurev.bb.04.060175.000355

Cited by 246 publications

(96 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The results of animal experiments [12] and computer modeling [10,11] clearly show that blood perfusion is the primary mechanism for heat removal from tissue volumes greater than a few cubic centimeters. Hence, many authorities now believe that the relatively low blood flow found in certain tumors as compared to surrounding normal tissue explains the selective heating of tumor tissue often observed during local hyperthermia [1-3, 10, 13-15].…”

Section: Introductionmentioning

confidence: 99%

Hydralazine-enhanced selective heating of transmissible venereal tumor implants in dogs

Voorhees

Babbs

1982

European Journal of Cancer and Clinical Oncology

106

View full text Add to dashboard Cite

This study was designed to test the hypothesis that vasodilator drugs can enhance selective heating of solid tumors by producing a favorable redistribution of blood flow between tumor and normal tissues. Subcutaneous transmissible venereal tumor implants were heated by inductive diathermy using Helmholtz coils in 8 dogs. The temperature rise in tumor and adjacent muscle was measured before and after giving hydralazine (0.5 mg/kg i.v.). Blood flow to the tumors and underlying muscle was measured with radioactive tracer microspheres. Before hydralazine treatment mean muscle blood flow was about one-third tumor blood flow (0.11  0.02 vs. 0.28  0.09 ml/min/g), and tumor and normal muscle temperatures were not significantly different (40.0  0.6 vs. 39.7  0.l o C). After hydralazine tumor blood flow decreased and muscle blood flow increased in every dog, and selective heating of the tumors became possible. Muscle blood flow averaged 0.67  0.13 ml/min/g, 17 times greater than tumor blood flow, which decreased to 0.04 0.02 ml/min/g. Core tumor temperature was 48.0  0.9 vs. 38.5  0.5 o C for underlying muscle. Blood pressure was maintained at 80  5.7 mmHg. These results demonstrate that adjuvant treatment with vasodilators is a promising technique to increase the temperature difference between tumors and surrounding normal tissues during local heat therapy.

show abstract

Section: Introductionmentioning

confidence: 99%

Hydralazine-enhanced selective heating of transmissible venereal tumor implants in dogs

Voorhees

Babbs

1982

European Journal of Cancer and Clinical Oncology

106

View full text Add to dashboard Cite

show abstract

“…K), perfusion rate which shows volume of blood per second flowing through a unit volume of tissue (1/s), heat source of metabolism and external heat source (W/m 3 ) respectively. Thermal properties of biomaterials such as retina, choroid differ greatly depending on measurement conditions [23]- [26].…”

Section: Determination Of the Temperature Rise In The Cause Of Ementioning

confidence: 99%

The Effect of the Electrical Stimulation on Temperature Rise in the Retinal Tissue for Visual Prostheses

Celik¹,

Karagöz²

2014

IJCEE

View full text Add to dashboard Cite

Abstract-Visual perception which is one of the most valuable perceptions for human beings may be lost over time because of various diseases such as Age Related Macular Degeneration (AMD) and Retinitis Pigmentosa (RP). These degenerative diseases cause severe damage to the certain parts of visual pathway and irreversible blindness. For the past last decades, with the improvements in the areas such as microelectronics, neuroscience and bioengineering, researches conducting on design and implementation of visual prosthetics become a promising therapeutic approach for the visual restoration. Visual perception, called phosphene, is reported to be obtained in studies which are based on electrical stimulation of the intact parts of the visual pathway. There are major factors that have to be considered in the design stage of a visual prosthesis system. One of them is the temperature change of the targeted retinal tissue and its surrounding due to electrical stimulation. In this study, a model is created to investigate thermal influence of an implant placed internal surface of the retinal tissue and solution is made using finite element analysis. It is shown that the temperature rise has highest value near the stimulation electrode and its surroundings in the case of using the model with thermal insulation. When the heat transfer mechanism is added to the simulation model, it is seen that the temperature rise is less and looks more realistic. With additive effect of heat transfer to the surrounding tissue and distance from stimulation electrode, temperature decreases away from the stimulation electrode.Index Terms-Electrical stimulation, finite element analysis, temperature change, visual prosthesis.

show abstract

“…In the present study, the thermal and physical properties of unfrozen tissues, including blood, are obtained from [190] and [187]. Volumetric flow rate of skin blood perfusion and metabolic heat generation are calculated from [186].…”

Section: Tissue Propertiesmentioning

confidence: 99%

Numerical Prediction of the Intracellular ICE Formation Zone during Cryosurgery on a Nodular Basal Cell Carcinoma Using Liquid Nitrogen Spray

Sun

Martı́nez-Suástegui

Wang

et al. 2012

International Journal of Spray and Combustion Dynamics

View full text Add to dashboard Cite

Cryosurgery is a surgical technique that employs freezing to destroy target tumor tissue. While the main objective during a cryosurgical procedure is to ensure tissue destruction within the cryolesion, the greatest challenge is how to spare the surrounding healthy tissues from cryoablation. In this work, a historical review of the field of cryosurgery is presented followed by a theoretical study where a mathematical model is developed for cryosurgery on a basal cell carcinoma (BCC) using liquid nitrogen (LN 2 ) spray. The model takes into consideration the anatomic structure of skin tissue and the irregular geometry of BCC. In particular, a methodology for quantitatively determining the extent of the intracellular ice formation (IIF) zone based on the tissue temperature and cooling rate (CR) is proposed, which can directly relate to the necrosis of the cancer cells after cryosurgery. The model is then used to analyze formation of the IIF zone during cryosurgery on a BCC and quantification is provided for the volume of the final IIF zone. A parametric study is also carried out to investigate the effect of various protocol parameters on the final IIF zone. The results should be useful for dermatologists for pre-treatment surgery planning.

show abstract

Theory, Measurement, and Application of Thermal Properties of Biomaterials

Cited by 246 publications

References 7 publications

Hydralazine-enhanced selective heating of transmissible venereal tumor implants in dogs

Hydralazine-enhanced selective heating of transmissible venereal tumor implants in dogs

The Effect of the Electrical Stimulation on Temperature Rise in the Retinal Tissue for Visual Prostheses

Numerical Prediction of the Intracellular ICE Formation Zone during Cryosurgery on a Nodular Basal Cell Carcinoma Using Liquid Nitrogen Spray

Contact Info

Product

Resources

About